PMID- 33719220
OWN - NLM
STAT- MEDLINE
DCOM- 20210707
LR  - 20210708
IS  - 2059-2310 (Electronic)
IS  - 2059-2302 (Print)
IS  - 2059-2302 (Linking)
VI  - 97
IP  - 6
DP  - 2021 Jun
TI  - Standard reference sequences for submission of HLA genotyping for the 18th 
      International HLA and Immunogenetics Workshop.
PG  - 512-519
LID - 10.1111/tan.14259 [doi]
AB  - The International human leukocyte antigen (HLA) and Immunogenetics Workshops 
      (IHIWs) have fostered international collaborations of researchers and experts in 
      the fields of HLA, histocompatibility and immunology. These IHIW collaborations 
      have comprised many projects focused on achieving a variety of specific goals. 
      The international and collaborative nature of these projects necessitates the 
      collection and analysis of complex data generated in multiple laboratories, often 
      using multiple methods of acquisition. Collection and storage of these data in a 
      consistent way adds value to IHIW projects, which can be extended to future work. 
      DNA-based genotyping data, especially HLA genotyping data, can be transmitted in 
      the form of a Histoimmunogenetics Markup Language (HML) document. HML facilitates 
      clear communication of a genotype and supporting metadata, such as, sequencing 
      platform, laboratory assays, consensus sequence, and interpretation. Sequence 
      information can be reported relative to known reference sequences, which add 
      meaning and context to genotypes. Selecting the correct reference sequence for a 
      given allele sequence is nuanced, and guidelines have emerged through 
      collaborative community efforts such as Data Standards Hackathons. Here, we 
      describe the guidelines established for the selection of reference sequences to 
      be used in transmission of HLA (and MICA/MICB) genotyping data for the 18th IHIW.
CI  - (c) 2021 The Authors. HLA: Immune Response Genetics published by John Wiley & Sons 
      Ltd.
FAU - Matern, Benedict M
AU  - Matern BM
AUID- ORCID: 0000-0002-9548-732X
AD  - Center of Translational Immunology, UMC Utrecht, Utrecht, the Netherlands.
FAU - Mack, Steven J
AU  - Mack SJ
AD  - Department of Pediatrics, University of California, Oakland, California, USA.
FAU - Osoegawa, Kazutoyo
AU  - Osoegawa K
AD  - Histocompatibility and Immunogenetics Laboratory, Stanford Blood Center, Palo 
      Alto, California, USA.
FAU - Maiers, Martin
AU  - Maiers M
AD  - Bioinformatics, National Marrow Donor Program/Be The Match, Minneapolis, 
      Minnesota, USA.
AD  - Bioinformatics, Center for International Blood and Marrow Transplant Research, 
      Minneapolis, Minnesota, USA.
FAU - Niemann, Matthias
AU  - Niemann M
AD  - Research and Development, PIRCHE AG, Berlin, Germany.
FAU - Robinson, James
AU  - Robinson J
AUID- ORCID: 0000-0002-2187-5944
AD  - Anthony Nolan Research Institute, Royal Free Campus, London, UK.
AD  - UCL Cancer Institute, University College London (UCL), London, UK.
FAU - Heidt, Sebastiaan
AU  - Heidt S
AD  - Department of Immunology, Leiden University Medical Center, Leiden, the 
      Netherlands.
FAU - Spierings, Eric
AU  - Spierings E
AD  - Center of Translational Immunology, UMC Utrecht, Utrecht, the Netherlands.
LA  - eng
GR  - R01 AI128775/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20210325
PL  - England
TA  - HLA
JT  - HLA
JID - 101675570
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Alleles
MH  - Genotype
MH  - *HLA Antigens/genetics
MH  - Histocompatibility Antigens Class I/genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - *Immunogenetics
PMC - PMC8251737
OTO - NOTNLM
OT  - HLA
OT  - HML
OT  - IHIW
OT  - reference sequence
OT  - workshop
COIS- Matthias Niemann is an employee of PIRCHE AG which runs the PIRCHE web-portal. 
      The authors have declared no conflicting interests.
EDAT- 2021/03/16 06:00
MHDA- 2021/07/08 06:00
PMCR- 2021/07/02
CRDT- 2021/03/15 07:34
PHST- 2021/02/25 00:00 [received]
PHST- 2021/03/10 00:00 [accepted]
PHST- 2021/03/16 06:00 [pubmed]
PHST- 2021/07/08 06:00 [medline]
PHST- 2021/03/15 07:34 [entrez]
PHST- 2021/07/02 00:00 [pmc-release]
AID - TAN14259 [pii]
AID - 10.1111/tan.14259 [doi]
PST - ppublish
SO  - HLA. 2021 Jun;97(6):512-519. doi: 10.1111/tan.14259. Epub 2021 Mar 25.