PMID- 33719524
OWN - NLM
STAT- MEDLINE
DCOM- 20210625
LR  - 20220111
IS  - 1558-9110 (Electronic)
IS  - 1058-0360 (Print)
IS  - 1058-0360 (Linking)
VI  - 30
IP  - 3S
DP  - 2021 Jun 18
TI  - Motor Speech Disorders and Communication Limitations in Progressive Supranuclear 
      Palsy.
PG  - 1361-1372
LID - 10.1044/2020_AJSLP-20-00126 [doi]
AB  - Purpose This study describes motor speech disorders and associated communication 
      limitations in six variants of progressive supranuclear palsy (PSP). Method The 
      presence, nature, and severity of dysarthria and apraxia of speech (AOS) were 
      documented, along with scores on the Apraxia of Speech Rating Scale-Version 3 
      (ASRS-3) for 77 (40 male and 37 female) patients with PSP. Clinician-estimated 
      and patient-estimated communication limitations were rated using the Motor Speech 
      Disorders Severity Rating (MSDSR) Scale and the Communicative Effectiveness 
      Survey (CES), respectively. Descriptive statistics were calculated for each of 
      these dependent variables. One-tailed t tests were conducted to test mean 
      differences in ASRS-3 and CES between participants with and without AOS and 
      between participants with and without dysarthria. Spearman rank correlations were 
      calculated between ASRS-3 scores and clinical judgments of AOS and dysarthria 
      severity and between MSDSR and CES ratings. Results Nine participants (12%) had 
      normal speech. Eighty-seven percent exhibited dysarthria; hypokinetic and mixed 
      hypokinetic-spastic dysarthria were observed most frequently. AOS was observed in 
      19.5% of participants across all variants, but in only 10% exclusive of the PSP 
      speech and language variant. Nearly half presented with AOS in which neither 
      phonetic nor prosodic features clearly predominated. The mean ASRS-3 score for 
      participants with AOS was significantly higher than for those without and 
      correlated strongly with clinician judgment of AOS severity. Mean ASRS-3 was 
      higher for participants with dysarthria than for those without but correlated 
      weakly with dysarthria severity. Mean MSDSR and CES ratings were lower in 
      participants with AOS compared to those without and moderately correlated with 
      each other. Conclusions Motor speech disorders that negatively impact 
      communicative effectiveness are common in PSP and occur in many variants. This is 
      the first description of motor speech disorders across PSP variants, setting the 
      stage for future research characterizing neuroanatomical correlates, progression 
      of motor speech disorders, and benefits of targeted interventions. Supplemental 
      Material https://doi.org/10.23641/asha.14111837.
FAU - Clark, Heather M
AU  - Clark HM
AD  - Department of Neurology, Mayo Clinic, Rochester, MN.
FAU - Utianski, Rene L
AU  - Utianski RL
AD  - Department of Neurology, Mayo Clinic, Rochester, MN.
FAU - Ali, Farwa
AU  - Ali F
AD  - Department of Neurology, Mayo Clinic, Rochester, MN.
FAU - Botha, Hugo
AU  - Botha H
AD  - Department of Neurology, Mayo Clinic, Rochester, MN.
FAU - Whitwell, Jennifer L
AU  - Whitwell JL
AD  - Department of Radiology, Mayo Clinic, Rochester, MN.
FAU - Josephs, Keith A
AU  - Josephs KA
AD  - Department of Neurology, Mayo Clinic, Rochester, MN.
LA  - eng
GR  - R01 DC012519/DC/NIDCD NIH HHS/United States
GR  - R01 NS089757/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20210309
PL  - United States
TA  - Am J Speech Lang Pathol
JT  - American journal of speech-language pathology
JID - 9114726
SB  - IM
MH  - *Apraxias/diagnosis
MH  - Dysarthria/diagnosis
MH  - Female
MH  - Humans
MH  - Language
MH  - Male
MH  - Speech
MH  - Speech Disorders/diagnosis
MH  - *Supranuclear Palsy, Progressive/complications/diagnosis
PMC - PMC8702836
EDAT- 2021/03/16 06:00
MHDA- 2021/06/29 06:00
PMCR- 2021/12/01
CRDT- 2021/03/15 12:30
PHST- 2021/03/16 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2021/03/15 12:30 [entrez]
PHST- 2021/12/01 00:00 [pmc-release]
AID - 23814764000300140072 [pii]
AID - 10.1044/2020_AJSLP-20-00126 [doi]
PST - ppublish
SO  - Am J Speech Lang Pathol. 2021 Jun 18;30(3S):1361-1372. doi: 
      10.1044/2020_AJSLP-20-00126. Epub 2021 Mar 9.