PMID- 33719591 OWN - NLM STAT- MEDLINE DCOM- 20211004 LR - 20211004 IS - 1940-1574 (Electronic) IS - 0003-3197 (Linking) VI - 72 IP - 9 DP - 2021 Oct TI - Inflammatory Indicators and Hematological Indices in Contrast-Induced Nephropathy Among Patients Receiving Coronary Intervention: A Systematic Review and Meta-Analysis. PG - 867-877 LID - 10.1177/00033197211000492 [doi] AB - Strong inflammatory indicators such as C-reactive protein (CRP), high-sensitivity CRP (hsCRP), and hematological indices, including platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), hematocrit (HCT), and red blood cell distribution width (RDW), may be related with contrast-induced nephropathy (CIN). Our meta-analysis aimed at exploring the relationship between these indicators and CIN incidence among patients undergoing coronary intervention. Clinical studies were retrieved from the electronic databases of PubMed, EMBASE, Google Scholar, Clinical Trials, and Science Direct from their inception to June 3, 2020. Meta-analysis was performed on pooled eligible studies. Finally, 26 studies involving 29 454 patients were included. Pooled analysis revealed that patients with higher CRP (odds ratio [OR] = 1.06, 95% CI: 1.01-1.12, P = .02), hsCRP (OR = 1.03, 95% CI: 1.01-1.06, P = .004), NLR (OR = 1.11, 95% CI: 1.01-1.20, P = .02), RDW (OR = 1.35, 95% CI: 1.19-1.53, P < .001), and lower HCT (OR = 0.94, 95% CI: 0.92-0.97, P = .003) all exhibited significantly higher CIN rates, but there was no significant association between PLR and CIN risk (OR = 1.12, 95% CI: 0.99-1.26, P = .07). Pre-angiography CRP/hsCRP and some hematological indices are associated with CIN. FAU - Wu, Xiaoyan AU - Wu X AD - Department of Pediatric Surgery, Tianjin Medical University General Hospital, Tianjin, China. FAU - Ma, Chao AU - Ma C AD - Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China. FAU - Sun, Daqing AU - Sun D AD - Department of Pediatric Surgery, Tianjin Medical University General Hospital, Tianjin, China. FAU - Zhang, Guojing AU - Zhang G AD - Department of Pediatric Surgery, Tianjin Medical University General Hospital, Tianjin, China. FAU - Wang, Jinmiao AU - Wang J AD - Department of Pediatric Surgery, Tianjin Medical University General Hospital, Tianjin, China. FAU - Zhang, Enyuan AU - Zhang E AUID- ORCID: 0000-0002-9192-2873 AD - Department of Cardiology, Tianjin Chest Hospital, Tianjin, China. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20210315 PL - United States TA - Angiology JT - Angiology JID - 0203706 RN - 0 (Biomarkers) RN - 0 (Contrast Media) RN - 0 (Inflammation Mediators) RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - Acute Kidney Injury/blood/*chemically induced/epidemiology MH - Aged MH - Biomarkers/blood MH - Blood Platelets MH - C-Reactive Protein/*analysis MH - Contrast Media/*adverse effects MH - Coronary Angiography/*adverse effects MH - Coronary Disease/blood/*diagnostic imaging/*therapy MH - Erythrocyte Indices MH - Female MH - Humans MH - Incidence MH - Inflammation Mediators/*blood MH - Lymphocyte Count MH - Lymphocytes MH - Male MH - Middle Aged MH - Neutrophils MH - Percutaneous Coronary Intervention/*adverse effects MH - Platelet Count MH - Risk Assessment MH - Risk Factors MH - Treatment Outcome OTO - NOTNLM OT - c-reactive protein OT - contrast-induced nephropathy OT - coronary intervention OT - hematocrit OT - neutrophil to lymphocyte ratio OT - platelet to lymphocyte ratio OT - red blood cell distribution width EDAT- 2021/03/16 06:00 MHDA- 2021/10/05 06:00 CRDT- 2021/03/15 12:33 PHST- 2021/03/16 06:00 [pubmed] PHST- 2021/10/05 06:00 [medline] PHST- 2021/03/15 12:33 [entrez] AID - 10.1177/00033197211000492 [doi] PST - ppublish SO - Angiology. 2021 Oct;72(9):867-877. doi: 10.1177/00033197211000492. Epub 2021 Mar 15.