PMID- 33721103
OWN - NLM
STAT- MEDLINE
DCOM- 20210804
LR  - 20220720
IS  - 1432-1416 (Electronic)
IS  - 0303-6812 (Print)
IS  - 0303-6812 (Linking)
VI  - 82
IP  - 5
DP  - 2021 Mar 15
TI  - Reduced biomechanical models for precision-cut lung-slice stretching experiments.
PG  - 35
LID - 10.1007/s00285-021-01578-2 [doi]
LID - 35
AB  - Precision-cut lung-slices (PCLS), in which viable airways embedded within lung 
      parenchyma are stretched or induced to contract, are a widely used ex vivo assay 
      to investigate bronchoconstriction and, more recently, mechanical activation of 
      pro-remodelling cytokines in asthmatic airways. We develop a nonlinear 
      fibre-reinforced biomechanical model accounting for smooth muscle contraction and 
      extracellular matrix strain-stiffening. Through numerical simulation, we describe 
      the stresses and contractile responses of an airway within a PCLS of finite 
      thickness, exposing the importance of smooth muscle contraction on the local 
      stress state within the airway. We then consider two simplifying limits of the 
      model (a membrane representation and an asymptotic reduction in the 
      thin-PCLS-limit), that permit analytical progress. Comparison against numerical 
      solution of the full problem shows that the asymptotic reduction successfully 
      captures the key elements of the full model behaviour. The more tractable reduced 
      model that we develop is suitable to be employed in investigations to elucidate 
      the time-dependent feedback mechanisms linking airway mechanics and cytokine 
      activation in asthma.
FAU - Pybus, Hannah J
AU  - Pybus HJ
AUID- ORCID: 0000-0002-9066-9503
AD  - School of Mathematical Sciences, University of Nottingham, University Park, 
      Nottingham, NG7 2RD, UK. hannah.pybus@nottingham.ac.uk.
FAU - Tatler, Amanda L
AU  - Tatler AL
AUID- ORCID: 0000-0002-4644-4614
AD  - Respiratory Medicine, NIHR Biomedical Research Centre, University of Nottingham, 
      Nottingham, UK.
FAU - Edgar, Lowell T
AU  - Edgar LT
AUID- ORCID: 0000-0002-8586-1605
AD  - Usher Institute of Population Health Sciences and Informatics, University of 
      Edinburgh, Edinburgh, UK.
FAU - O'Dea, Reuben D
AU  - O'Dea RD
AUID- ORCID: 0000-0002-1284-9103
AD  - School of Mathematical Sciences, University of Nottingham, University Park, 
      Nottingham, NG7 2RD, UK.
FAU - Brook, Bindi S
AU  - Brook BS
AUID- ORCID: 0000-0001-9883-4131
AD  - School of Mathematical Sciences, University of Nottingham, University Park, 
      Nottingham, NG7 2RD, UK.
LA  - eng
GR  - MR/M004643/1/MRC_/Medical Research Council/United Kingdom
GR  - MRF_MRF-009-0001-RG-TATLE/MRF/MRF/United Kingdom
GR  - NC/K500501/1/NC3RS_/National Centre for the Replacement, Refinement and Reduction 
      of Animals in Research/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210315
PL  - Germany
TA  - J Math Biol
JT  - Journal of mathematical biology
JID - 7502105
RN  - 0 (Cytokines)
SB  - IM
MH  - Biomechanical Phenomena
MH  - Bronchoconstriction
MH  - Computer Simulation
MH  - Cytokines/chemistry
MH  - Extracellular Matrix/chemistry
MH  - Humans
MH  - *Lung/chemistry
MH  - *Models, Theoretical
MH  - Muscle Contraction/physiology
PMC - PMC7960642
OTO - NOTNLM
OT  - Airway mechanics
OT  - Asthma
OT  - Asymptotics
OT  - Soft tissue mechanics
EDAT- 2021/03/16 06:00
MHDA- 2021/08/05 06:00
PMCR- 2021/03/15
CRDT- 2021/03/15 17:32
PHST- 2020/01/25 00:00 [received]
PHST- 2021/02/14 00:00 [accepted]
PHST- 2020/08/25 00:00 [revised]
PHST- 2021/03/15 17:32 [entrez]
PHST- 2021/03/16 06:00 [pubmed]
PHST- 2021/08/05 06:00 [medline]
PHST- 2021/03/15 00:00 [pmc-release]
AID - 10.1007/s00285-021-01578-2 [pii]
AID - 1578 [pii]
AID - 10.1007/s00285-021-01578-2 [doi]
PST - epublish
SO  - J Math Biol. 2021 Mar 15;82(5):35. doi: 10.1007/s00285-021-01578-2.