PMID- 33721813
OWN - NLM
STAT- MEDLINE
DCOM- 20210421
LR  - 20231213
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1642
DP  - 2021 Apr 12
TI  - A rapid method for the simultaneous stereoselective determination of the triazole 
      fungicides in tobacco by supercritical fluid chromatography-tandem mass 
      spectrometry combined with pass-through cleanup.
PG  - 462040
LID - S0021-9673(21)00164-3 [pii]
LID - 10.1016/j.chroma.2021.462040 [doi]
AB  - This work presents a simple, rapid and green chiral analysis method for five 
      triazole fungicides (penconazole, tebuconazole, triadimefon, myclobutanil, and 
      triadimenol) in tobacco, by which the samples were cleaned up by the novel 
      pass-through solid phase extraction and subsequently the stereoisomers were 
      separated and determined by the supercritical fluid chromatography-tandem mass 
      spectrometry (SFC-MS/MS). Optimized separation of the stereoisomers was achieved 
      on an ACQUITY UPC2 Trefoil AMY 1 column within 6 min. Under fortified 
      concentration levels of 0.1, 0.5 and 2.0 mg/kg, the mean recoveries were 
      82.8-106.6%, the intra-day relative standard deviations (RSDs) were 1.1-6.6%, and 
      the inter-day RSDs were 2.5-5.6%. The correlation coefficient was greater than 
      0.9926 for all studied analytes within the range of 10-500 ng/mL. The limits of 
      detection (LODs) for all stereoisomers ranged from 0.26 mug/kg to 3.24 mug/kg. The 
      established method was subsequently successfully applied to analyze authentic 
      samples, confirming that this method is a novel, rapid and environmentally 
      friendly method for the stereoselective separation of triazole fungicides in 
      tobacco.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Yang, Fei
AU  - Yang F
AD  - China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, 
      China.
FAU - Zhang, Xiaotao
AU  - Zhang X
AD  - China tobacco Guizhou Industrial Co. Ltd, Guiyang 550009, China.
FAU - Shao, Jimin
AU  - Shao J
AD  - Sichuan Tobacco Quality Supervision and Testing Station, Chengdu 610041, China.
FAU - Xiong, Wei
AU  - Xiong W
AD  - Sichuan Tobacco Quality Supervision and Testing Station, Chengdu 610041, China.
FAU - Ji, Yuan
AU  - Ji Y
AD  - China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, 
      China.
FAU - Liu, Shanshan
AU  - Liu S
AD  - China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, 
      China.
FAU - Tang, Gangling
AU  - Tang G
AD  - China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, 
      China.
FAU - Deng, Huimin
AU  - Deng H
AD  - China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, 
      China.
FAU - Wang, Ying
AU  - Wang Y
AD  - China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, 
      China. Electronic address: carobit@126.com.
LA  - eng
PT  - Journal Article
DEP - 20210305
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Fungicides, Industrial)
RN  - 0 (Nitriles)
RN  - 0 (Solvents)
RN  - 0 (Triazoles)
RN  - 1HW039CJF0 (triadimefon)
RN  - 3UN9F9ZJ43 (penconazole)
RN  - 401ATW8TRW (tebuconazole)
RN  - B6T1JTM6KZ (systhane)
SB  - IM
MH  - Calibration
MH  - Chromatography, Supercritical Fluid/*methods
MH  - Fungicides, Industrial/*analysis/chemistry
MH  - Limit of Detection
MH  - Nitriles/analysis/chemistry
MH  - Reproducibility of Results
MH  - Solid Phase Extraction
MH  - Solvents
MH  - Stereoisomerism
MH  - Tandem Mass Spectrometry/*methods
MH  - Nicotiana/*chemistry
MH  - Triazoles/*analysis/chemistry
OTO - NOTNLM
OT  - Pass-through cleanup
OT  - SFC-MS/MS
OT  - Stereoselective separation
OT  - Tobacco
OT  - Triazole fungicides
COIS- Declaration of Competing Interest The authors have declared no conflict of 
      interest.
EDAT- 2021/03/16 06:00
MHDA- 2021/04/22 06:00
CRDT- 2021/03/15 20:22
PHST- 2020/12/23 00:00 [received]
PHST- 2021/02/24 00:00 [revised]
PHST- 2021/02/27 00:00 [accepted]
PHST- 2021/03/16 06:00 [pubmed]
PHST- 2021/04/22 06:00 [medline]
PHST- 2021/03/15 20:22 [entrez]
AID - S0021-9673(21)00164-3 [pii]
AID - 10.1016/j.chroma.2021.462040 [doi]
PST - ppublish
SO  - J Chromatogr A. 2021 Apr 12;1642:462040. doi: 10.1016/j.chroma.2021.462040. Epub 
      2021 Mar 5.