PMID- 33723630
OWN - NLM
STAT- MEDLINE
DCOM- 20211203
LR  - 20211214
IS  - 1439-6327 (Electronic)
IS  - 1439-6319 (Print)
IS  - 1439-6319 (Linking)
VI  - 121
IP  - 7
DP  - 2021 Jul
TI  - Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but 
      not other inflammatory cytokines in trained older men.
PG  - 1909-1919
LID - 10.1007/s00421-021-04635-2 [doi]
AB  - PURPOSE: The present study aimed to investigate the effect of age on circulating 
      pro- and anti-inflammatory cytokines and growth factors. A secondary aim was to 
      investigate whether a novel sprint interval training (SIT) intervention (3 x 20 s 
      'all out' static sprints, twice a week for 8 weeks) would affect inflammatory 
      markers in older men. METHODS: Nine older men [68 (1) years] and eleven younger 
      men [28 (2) years] comprised the younger group. Aerobic fitness and inflammatory 
      markers were taken at baseline for both groups and following the SIT intervention 
      for the older group. RESULTS: Interleukin (IL)-8, vascular endothelial growth 
      factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1) were unchanged for 
      the older and younger groups at baseline (IL-8, p = 0.819; MCP-1, p = 0.248; 
      VEGF, p = 0.264). Epidermal growth factor (EGF) was greater in the older group 
      compared to the younger group at baseline [142 (20) pg mL(-1) and 60 (12) pg 
      mL(-1), respectively, p = 0.001, Cohen's d = 1.64]. Following SIT, older men 
      decreased EGF to 100 (12) pg mL(-1) which was similar to that of young men who 
      did not undergo training (p = 0.113, Cohen's d = 1.07). CONCLUSION: Older 
      aerobically trained men have greater serum EGF than younger aerobically trained 
      men. A novel SIT intervention in older men can shift circulating EGF towards 
      trained younger concentrations. As lower EGF has previously been associated with 
      longevity in C. elegans, the manipulative effect of SIT on EGF in healthy ageing 
      in the human may be of further interest.
FAU - Yasar, Zerbu
AU  - Yasar Z
AUID- ORCID: 0000-0001-8838-7286
AD  - Active Ageing Research Group, Institute of Health, University of Cumbria, 
      Lancaster, UK.
FAU - Elliott, Bradley T
AU  - Elliott BT
AUID- ORCID: 0000-0003-4295-3785
AD  - Translational Physiology Research Group, School of Life Sciences, College of 
      Liberal Arts and Sciences, University of Westminster, 115 New Cavendish St, 
      London, W1W 6UW, UK. b.elliott@westminster.ac.uk.
FAU - Kyriakidou, Yvoni
AU  - Kyriakidou Y
AUID- ORCID: 0000-0002-8883-2228
AD  - Translational Physiology Research Group, School of Life Sciences, College of 
      Liberal Arts and Sciences, University of Westminster, 115 New Cavendish St, 
      London, W1W 6UW, UK.
FAU - Nwokoma, Chiazor T
AU  - Nwokoma CT
AUID- ORCID: 0000-0002-2931-5992
AD  - Translational Physiology Research Group, School of Life Sciences, College of 
      Liberal Arts and Sciences, University of Westminster, 115 New Cavendish St, 
      London, W1W 6UW, UK.
FAU - Postlethwaite, Ruth D
AU  - Postlethwaite RD
AUID- ORCID: 0000-0003-3888-9338
AD  - Active Ageing Research Group, Institute of Health, University of Cumbria, 
      Lancaster, UK.
AD  - Faculty of Health and Life Sciences, Coventry University, Coventry, UK.
FAU - Gaffney, Christopher J
AU  - Gaffney CJ
AUID- ORCID: 0000-0001-7990-2792
AD  - Lancaster Medical School, Faculty of Health and Medicine, Lancaster University, 
      Lancaster, UK.
FAU - Dewhurst, Susan
AU  - Dewhurst S
AUID- ORCID: 0000-0003-2747-9122
AD  - Department of Rehabilitation and Sport Sciences, Bournemouth University, 
      Bournemouth, UK.
FAU - Hayes, Lawrence D
AU  - Hayes LD
AUID- ORCID: 0000-0002-6654-0072
AD  - Active Ageing Research Group, Institute of Health, University of Cumbria, 
      Lancaster, UK.
AD  - School of Health and Life Sciences, University of the West of Scotland, Glasgow, 
      UK.
LA  - eng
PT  - Journal Article
DEP - 20210316
PL  - Germany
TA  - Eur J Appl Physiol
JT  - European journal of applied physiology
JID - 100954790
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 62229-50-9 (Epidermal Growth Factor)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Anthropometry
MH  - Biomarkers/blood
MH  - Cytokines/*blood
MH  - Epidermal Growth Factor/*blood
MH  - *High-Intensity Interval Training
MH  - Humans
MH  - Male
MH  - Middle Aged
PMC - PMC8192388
OTO - NOTNLM
OT  - Ageing
OT  - Cytokines
OT  - Exercise
OT  - Growth factors
OT  - HIIT
OT  - Inflammation
COIS- We declare no conflict of interest or competing interests.
EDAT- 2021/03/17 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/03/16
CRDT- 2021/03/16 06:56
PHST- 2020/07/06 00:00 [received]
PHST- 2021/02/05 00:00 [accepted]
PHST- 2021/03/17 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/03/16 06:56 [entrez]
PHST- 2021/03/16 00:00 [pmc-release]
AID - 10.1007/s00421-021-04635-2 [pii]
AID - 4635 [pii]
AID - 10.1007/s00421-021-04635-2 [doi]
PST - ppublish
SO  - Eur J Appl Physiol. 2021 Jul;121(7):1909-1919. doi: 10.1007/s00421-021-04635-2. 
      Epub 2021 Mar 16.