PMID- 33724668
OWN - NLM
STAT- MEDLINE
DCOM- 20220117
LR  - 20220117
IS  - 1464-410X (Electronic)
IS  - 1464-4096 (Linking)
VI  - 129
IP  - 1
DP  - 2022 Jan
TI  - Loop-tail stents fail in reducing stent-related symptoms: results of a 
      prospective randomised controlled trial.
PG  - 123-129
LID - 10.1111/bju.15395 [doi]
AB  - OBJECTIVE: To compare stent-related symptoms (SRS) of loop-tail (LT) and 
      conventional double J (DJ) stents after uncomplicated flexible ureterorenoscopy 
      (fURS), in a prospective randomised controlled single-blind parallel-group study. 
      PATIENTS AND METHODS: Patients undergoing fURS were randomised into two groups: 
      the LT Group received LT stents (Polaris Loop) and the DJ Group received 
      conventional DJ stents (Vortek((R)) ). The stent was removed after 4 weeks. The 
      Ureteric Stent Symptom Questionnaire (USSQ) was administered at 2 days, 4 and 
      8 weeks (baseline evaluation) after stent insertion. The primary endpoint was to 
      compare the Urinary Symptom Index Score of the LT vs DJ groups at 4 weeks after 
      stent insertion. The secondary endpoints were to compare the USSQ domains' 
      subscores at 2 days and 4 weeks after stent insertion, USSQ single answers at 
      4 weeks, and the 4-week USSQ domains' subscores adjusted for baseline. RESULTS: A 
      total of 68 patients were randomised (34 LT and 34 DJ). The answers given at 4 
      weeks were not significantly different between the two groups for the Urinary 
      Symptom Index Score (P = 0.982), Pain Index Score (P = 0.169), visual analogue 
      scale (P = 0.276), and all the other domains of the USSQ. At 4 weeks, the 
      single-answer analysis did not find any differences between the groups; the 
      urinary symptoms were all comparable, as was the requirement for pain painkillers 
      (P = 0.684) and pain during sex (P = 0.496). There were also no significant 
      differences for every single domain score for the responses given at 2 days. The 
      same applied to USSQ subscores at 4 weeks adjusted for the 8-week baseline 
      results, which were also comparable. CONCLUSIONS: The study found no differences 
      in terms of SRS between the LT and DJ groups, either at 2 days or 4 weeks after 
      stent insertion, with or without baseline correction.
CI  - (c) 2021 The Authors BJU International (c) 2021 BJU International Published by John 
      Wiley & Sons Ltd.
FAU - Bosio, Andrea
AU  - Bosio A
AUID- ORCID: 0000-0001-8511-897X
AD  - Department of Urology, Citta della Salute e della Scienza, Molinette University 
      Hospital, Turin, Italy.
FAU - Alessandria, Eugenio
AU  - Alessandria E
AD  - Department of Urology, Citta della Salute e della Scienza, Molinette University 
      Hospital, Turin, Italy.
FAU - Agosti, Simone Carlo
AU  - Agosti SC
AD  - Department of Urology, Citta della Salute e della Scienza, Molinette University 
      Hospital, Turin, Italy.
FAU - Vitiello, Federico
AU  - Vitiello F
AD  - Department of Urology, Citta della Salute e della Scienza, Molinette University 
      Hospital, Turin, Italy.
FAU - Vercelli, Eugenia
AU  - Vercelli E
AD  - Department of Urology, Citta della Salute e della Scienza, Molinette University 
      Hospital, Turin, Italy.
FAU - Bisconti, Alessandro
AU  - Bisconti A
AD  - Department of Urology, Citta della Salute e della Scienza, Molinette University 
      Hospital, Turin, Italy.
FAU - Fop, Fabrizio
AU  - Fop F
AD  - Department of Nephrology, Dialysis and Kidney Transplantation, Citta della Salute 
      e della Scienza, Molinette University Hospital, Turin, Italy.
FAU - Gontero, Paolo
AU  - Gontero P
AUID- ORCID: 0000-0002-9714-6596
AD  - Department of Urology, Citta della Salute e della Scienza, Molinette University 
      Hospital, Turin, Italy.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20210505
PL  - England
TA  - BJU Int
JT  - BJU international
JID - 100886721
RN  - 0 (Analgesics)
SB  - IM
MH  - Aged
MH  - Analgesics/therapeutic use
MH  - Dyspareunia/etiology
MH  - Equipment Design/*adverse effects
MH  - Female
MH  - Humans
MH  - Kidney Calculi/surgery
MH  - Male
MH  - Middle Aged
MH  - Pain/drug therapy/*etiology
MH  - Prospective Studies
MH  - Sexual Behavior
MH  - Single-Blind Method
MH  - Stents/*adverse effects
MH  - Surveys and Questionnaires
MH  - Symptom Assessment
MH  - Time Factors
MH  - Ureteroscopy
OTO - NOTNLM
OT  - #EndoUrology
OT  - #Urology
OT  - LUTS
OT  - RIRS
OT  - URS
OT  - double J
OT  - loop-tail stents
OT  - pain
OT  - stent-related symptoms
OT  - stents
OT  - ureteroscopy
OT  - urinary calculi
EDAT- 2021/03/17 06:00
MHDA- 2022/01/18 06:00
CRDT- 2021/03/16 12:56
PHST- 2021/03/17 06:00 [pubmed]
PHST- 2022/01/18 06:00 [medline]
PHST- 2021/03/16 12:56 [entrez]
AID - 10.1111/bju.15395 [doi]
PST - ppublish
SO  - BJU Int. 2022 Jan;129(1):123-129. doi: 10.1111/bju.15395. Epub 2021 May 5.