PMID- 33725525
OWN - NLM
STAT- MEDLINE
DCOM- 20211206
LR  - 20211214
IS  - 1872-7603 (Electronic)
IS  - 0165-0378 (Linking)
VI  - 145
DP  - 2021 Jun
TI  - HLA-DRB1 polymorphism in recurrent pregnancy loss: New evidence for an 
      association to HLA-DRB1*07.
PG  - 103308
LID - S0165-0378(21)00038-3 [pii]
LID - 10.1016/j.jri.2021.103308 [doi]
AB  - Many cases of recurrent pregnancy loss (RPL) defined as >/=3 consecutive pregnancy 
      losses are suggested to be caused by an aberrant maternal immune response against 
      the fetus or trophoblast. Human leukocyte antigen (HLA)-DRB1 and -DQB1 
      polymorphisms are associated with most autoimmune disorders and studies of 
      HLA-DBB1 polymorphism in RPL patients are thus relevant. In previous studies, the 
      HLA-DRB1*03 allele was found with increased prevalence in RPL patients. We wanted 
      to clarify whether HLA-DRB1 alleles indeed were associated with RPL among women 
      of Caucasian descent. A total of 1078 women with unexplained RPL and 2066 bone 
      marrow donors were HLA-DRB1-typed and subsets were also HLA-DQB1 typed. All 
      patients were initially HLA-DRB1-typed by DNA-based low-resolution techniques and 
      subsets of patients and all controls were typed by high-resolution techniques. 
      Among patients, the HLA-DRB1*07 allele frequency was significantly increased 
      compared with controls; OR 1.29 (95 % CI 1.09-1.52), p < 0.0025; after correction 
      for multiple comparisons pc = 0.031. The HLA-DRB1*07/*07 genotype was highly 
      increased in patients with RPL compared with controls: OR 2.27 (1.31-3.93), p = 
      0.0027. The frequency of the HLA-DRB1*07 phenotype in RPL patients had increased 
      significantly (p = 0.002) in three studies from our group published 1994-2021. 
      The allele frequency of HLA-DRB1*03 was not increased in RPL patients compared 
      with controls; OR 0.96 (0.83-1.12). In conclusion, the previous association 
      between HLA-DRB1*03 and RPL could not be confirmed in our study whereas an 
      association to HLA-DRB1*07 was detected for the first time. Since the latter 
      association is a new finding, it should be confirmed in future studies.
CI  - Copyright (c) 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
FAU - Thomsen, C K
AU  - Thomsen CK
AD  - Centre for Recurrent Pregnancy Loss of Western Denmark, Department of Obstetrics 
      and Gynaecology, Aalborg University Hospital, Aalborg, Denmark.
FAU - Steffensen, R
AU  - Steffensen R
AD  - Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark.
FAU - Nielsen, H S
AU  - Nielsen HS
AD  - Recurrent Pregnancy Loss Unit Capital Region, Copenhagen University Hospital, 
      Rigshospitalet and Hvidovre Hospital, Copenhagen, Denmark; Department of 
      Obstetrics and Gynaecology, Hvidovre Hospital, Copenhagen University Hospital, 
      Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health Sciences, 
      University of Copenhagen, Denmark.
FAU - Kolte, A M
AU  - Kolte AM
AD  - Recurrent Pregnancy Loss Unit Capital Region, Copenhagen University Hospital, 
      Rigshospitalet and Hvidovre Hospital, Copenhagen, Denmark; Department of Clinical 
      Medicine, Faculty of Health Sciences, University of Copenhagen, Denmark.
FAU - Krog, M C
AU  - Krog MC
AD  - Recurrent Pregnancy Loss Unit Capital Region, Copenhagen University Hospital, 
      Rigshospitalet and Hvidovre Hospital, Copenhagen, Denmark; Department of Clinical 
      Immunology, Copenhagen University Hospital, Rigshospitalet, Denmark.
FAU - Egerup, P
AU  - Egerup P
AD  - Recurrent Pregnancy Loss Unit Capital Region, Copenhagen University Hospital, 
      Rigshospitalet and Hvidovre Hospital, Copenhagen, Denmark; Department of 
      Obstetrics and Gynaecology, Hvidovre Hospital, Copenhagen University Hospital, 
      Copenhagen, Denmark.
FAU - Larsen, E C
AU  - Larsen EC
AD  - Recurrent Pregnancy Loss Unit Capital Region, Copenhagen University Hospital, 
      Rigshospitalet and Hvidovre Hospital, Copenhagen, Denmark.
FAU - Hviid, T V
AU  - Hviid TV
AD  - Department of Clinical Biochemistry, Centre for Immune Regulation and 
      Reproductive Immunology (CIRRI), the ReproHealth Research Consortium ZUH, Zealand 
      University Hospital and Department of Clinical Medicine, University of 
      Copenhagen, Denmark.
FAU - Christiansen, O B
AU  - Christiansen OB
AD  - Centre for Recurrent Pregnancy Loss of Western Denmark, Department of Obstetrics 
      and Gynaecology, Aalborg University Hospital, Aalborg, Denmark; Recurrent 
      Pregnancy Loss Unit Capital Region, Copenhagen University Hospital, 
      Rigshospitalet and Hvidovre Hospital, Copenhagen, Denmark; Department of Clinical 
      Medicine, Faculty of Health Sciences, Aalborg University, Denmark. Electronic 
      address: olbc@rn.dk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210309
PL  - Ireland
TA  - J Reprod Immunol
JT  - Journal of reproductive immunology
JID - 8001906
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*07 antigen)
SB  - IM
MH  - Abortion, Habitual/*genetics/immunology
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - HLA-DRB1 Chains/*genetics
MH  - Healthy Volunteers
MH  - Homozygote
MH  - Humans
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Pregnancy
MH  - Young Adult
OTO - NOTNLM
OT  - Case-control study
OT  - HLA-DRB1
OT  - Recurrent miscarriage
OT  - Recurrent pregnancy loss
EDAT- 2021/03/17 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/03/16 20:12
PHST- 2020/10/16 00:00 [received]
PHST- 2021/01/15 00:00 [revised]
PHST- 2021/03/03 00:00 [accepted]
PHST- 2021/03/17 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/03/16 20:12 [entrez]
AID - S0165-0378(21)00038-3 [pii]
AID - 10.1016/j.jri.2021.103308 [doi]
PST - ppublish
SO  - J Reprod Immunol. 2021 Jun;145:103308. doi: 10.1016/j.jri.2021.103308. Epub 2021 
      Mar 9.