PMID- 33725608
OWN - NLM
STAT- MEDLINE
DCOM- 20210520
LR  - 20221207
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 778
DP  - 2021 Jul 15
TI  - Estimation of the psychoactive substances consumption within 12 wastewater 
      treatment plants service areas in a certain city of Guangxi, China applying 
      wastewater-based epidemiology.
PG  - 146370
LID - S0048-9697(21)01438-8 [pii]
LID - 10.1016/j.scitotenv.2021.146370 [doi]
AB  - The abuse of psychoactive substances has been increasing dramatically over the 
      last few years, which is becoming a concern for human health and social 
      stability. How to accurately estimate psychoactive substances' total consumption 
      in certain areas is the key to manage such substances. In order to control 
      psychoactive substances, 8 psychoactive substances' consumption within 12 
      wastewater treatment plants (WWTPs) service areas in a certain city of Guangxi, 
      China was investigated in 2019. Firstly, a solid-phase extraction-liquid 
      chromatography-tandem mass spectrometry method was used to determine the influent 
      concentrations. Morphine (MOR), 3, 4-methylenedioxymethamphetamine (MDMA), 
      methamphetamine (METH), ketamine (KET), and norketamine (NK) were detected, with 
      the concentrations ranging from less than method detection limit (NK, MDMA) to 
      170.91 (METH) ng/L. Then, the back-estimation of consumption was conducted 
      according to the objective and near real-time wastewater-based epidemiology 
      (WBE). The results demonstrate that KET, MOR, and METH are the most abused 
      psychoactive substances, with the mean consumption of 682.42, 167.81, and 
      44.56 mg/day/1000 inh, respectively. The psychoactive substance residues of WWTPs 
      influent were analyzed to estimate such substances' consumption in specific 
      areas, so as to provide support for risk prevention and control.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Jin, Hangbiao
AU  - Jin H
AD  - College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang 
      310032, PR China.
FAU - Yang, Dan
AU  - Yang D
AD  - College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang 
      310032, PR China.
FAU - Hao, Yunbin
AU  - Hao Y
AD  - Hangzhou Ruide Life Technology Co., Ltd., Hangzhou, Zhejiang 311121, PR China.
FAU - Zhang, Jinyang
AU  - Zhang J
AD  - Hangzhou Ruide Life Technology Co., Ltd., Hangzhou, Zhejiang 311121, PR China.
FAU - Wu, Pengfei
AU  - Wu P
AD  - State Key Laboratory of Environmental and Biological Analysis, Department of 
      Chemistry, Hong Kong Baptist University, Hong Kong, China.
FAU - Liu, Weiping
AU  - Liu W
AD  - State Key Laboratory of Environmental and Biological Analysis, Department of 
      Chemistry, Hong Kong Baptist University, Hong Kong, China.
FAU - Zhao, Meirong
AU  - Zhao M
AD  - College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang 
      310032, PR China. Electronic address: zhaomr@zjut.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210311
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Illicit Drugs)
RN  - 0 (Waste Water)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - China/epidemiology
MH  - Cities
MH  - Humans
MH  - *Illicit Drugs
MH  - Substance Abuse Detection
MH  - Tandem Mass Spectrometry
MH  - Wastewater/analysis
MH  - Wastewater-Based Epidemiological Monitoring
MH  - *Water Pollutants, Chemical/analysis
MH  - *Water Purification
OTO - NOTNLM
OT  - Consumption
OT  - LC-MS/MS
OT  - Occurrence
OT  - Psychoactive substance
OT  - Wastewater-based epidemiology
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/03/17 06:00
MHDA- 2021/05/21 06:00
CRDT- 2021/03/16 20:16
PHST- 2021/01/08 00:00 [received]
PHST- 2021/03/03 00:00 [revised]
PHST- 2021/03/05 00:00 [accepted]
PHST- 2021/03/17 06:00 [pubmed]
PHST- 2021/05/21 06:00 [medline]
PHST- 2021/03/16 20:16 [entrez]
AID - S0048-9697(21)01438-8 [pii]
AID - 10.1016/j.scitotenv.2021.146370 [doi]
PST - ppublish
SO  - Sci Total Environ. 2021 Jul 15;778:146370. doi: 10.1016/j.scitotenv.2021.146370. 
      Epub 2021 Mar 11.