PMID- 33725812
OWN - NLM
STAT- MEDLINE
DCOM- 20210329
LR  - 20230103
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 100
IP  - 10
DP  - 2021 Mar 12
TI  - Renal metastases from esophageal cancer and retroperitoneal lymphoma detected via 
      chromosome duplications identified by fluorescence in situ hybridization in urine 
      exfoliated cells: First 2 case reports.
PG  - e24010
LID - 10.1097/MD.0000000000024010 [doi]
LID - e24010
AB  - RATIONALE: Renal-occupying lesions positive for urine fluorescence in situ 
      hybridization (FISH) are usually considered urothelial carcinomas. Here, we 
      describe 2 cases of renal metastases with chromosome duplications in urine 
      exfoliated cells. PATIENT SYMPTOMS: Patient 1, a 56-year-old male with a history 
      of esophageal cancer, was admitted to our hospital on May 2017 after presenting 
      with right back pain with microscopic hematuria for 1 month. Magnetic resonance 
      imaging (MRI) showed right renal space-occupying lesions (5.4 cm x 4.6 cm) and 
      multiple enlarged lymph nodes in the right renal hilum and retroperitoneum. The 
      cystoscopy results were negative, and FISH analysis of urine exfoliated cells was 
      positive, indicative of chromosome 3, 7, and 17 amplifications. Patient 2 was a 
      50-year-old male who was admitted to our hospital on May 2019 with no obvious 
      cause of abdominal pain and abdominal distension (lasting for 7 days), with a 
      serum creatinine level of 844 mumol/L. Patient 2 had no hematuria or fever, and 
      MRI showed left renal inferior and medial space-occupying lesions, and multiple 
      mesenteric nodules at the junction of the left adrenal gland, retroperitoneum, 
      abdomen, and pelvis, which were partially fused. The tumor lesions were 
      approximately 3.1 cm x 2.3 cm in size. The urine FISH results were positive, 
      indicating chromosome 3, 7, and 17 amplifications. DIAGNOSES: Both patients were 
      diagnosed with renal tumors with unknown pathology. INTERVENTIONS: Patient 1 
      underwent laparoscopic resection of the kidney and ureter, and sleeve cystectomy. 
      The postoperative pathological diagnosis was metastatic keratinized squamous cell 
      carcinoma, with squamous cell carcinoma in the right hilar lymph node. 
      Histological FISH of the primary esophageal cancer and renal metastases were 
      consistent with the urine FISH test results. Patient 2 underwent a biopsy of the 
      left renal inferior and retroperitoneal areas, and was diagnosed with diffuse 
      large B-cell lymphoma. OUTCOMES: Patient 1 survived 6 months after urological 
      surgery. After treating patient 2 with the R-CHOP regimen and kinase inhibitors, 
      his renal function recovered significantly and the mass become undetectable. 
      LESSONS: Our results imply that FISH-positive renal occupying lesions should be 
      considered as potential renal metastases with chromosome aberrations when making 
      a differential diagnosis.
CI  - Copyright (c) 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Hu, Zhiquan
AU  - Hu Z
AD  - Department of Urology, Tongji Hospital Affiliated Tongji Medical College of 
      Huazhong University of Science and Technology (HUST), 1095 Jiefang Avenue, Wuhan, 
      China.
FAU - Ke, Chunjin
AU  - Ke C
FAU - Shen, Yuanqing
AU  - Shen Y
FAU - Zeng, Xing
AU  - Zeng X
FAU - Yang, Chunguang
AU  - Yang C
AUID- ORCID: 0000-0002-3882-4940
LA  - eng
GR  - 81702989/National Natural Science Foundation of China/
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Chromosome Duplication
MH  - Esophageal Neoplasms/diagnosis/genetics/*pathology/urine
MH  - Esophagus/diagnostic imaging
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney/diagnostic imaging/pathology/surgery
MH  - Kidney Neoplasms/*diagnosis/genetics/secondary/urine
MH  - Liquid Biopsy/methods
MH  - Lymph Nodes/diagnostic imaging
MH  - Lymphoma/genetics/*pathology/urine
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Retroperitoneal Neoplasms/genetics/*pathology/urine
MH  - Retroperitoneal Space/diagnostic imaging
MH  - Tomography, X-Ray Computed
MH  - Urinalysis/methods
PMC - PMC7969301
EDAT- 2021/03/18 06:00
MHDA- 2021/03/30 06:00
PMCR- 2021/03/12
CRDT- 2021/03/17 01:08
PHST- 2020/02/03 00:00 [received]
PHST- 2020/12/03 00:00 [accepted]
PHST- 2021/03/17 01:08 [entrez]
PHST- 2021/03/18 06:00 [pubmed]
PHST- 2021/03/30 06:00 [medline]
PHST- 2021/03/12 00:00 [pmc-release]
AID - 00005792-202103120-00006 [pii]
AID - MD-D-20-00658 [pii]
AID - 10.1097/MD.0000000000024010 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2021 Mar 12;100(10):e24010. doi: 
      10.1097/MD.0000000000024010.