PMID- 33726936
OWN - NLM
STAT- MEDLINE
DCOM- 20210920
LR  - 20210920
IS  - 0929-6646 (Print)
IS  - 0929-6646 (Linking)
VI  - 120
IP  - 10
DP  - 2021 Oct
TI  - Clinical use of intravenous immunoglobulin in Taiwan: A 10-year population study.
PG  - 1921-1925
LID - S0929-6646(21)00081-4 [pii]
LID - 10.1016/j.jfma.2021.02.017 [doi]
AB  - Intravenous immunoglobulin (IVIG) is used in the treatment of immunological, 
      inflammatory and neurological conditions. We aimed to describe the trends in IVIG 
      utilization in Taiwan. We identified patients receiving IVIG through the national 
      health insurance (NHI) database. We described the distribution of IVIG use 
      according to main indications. During 2008-2017, IVIG distribution grew 10% per 
      year on average. The population IVIG dose was 8.0 g per thousand capita. Among 
      the total distribution, approximately 60% were NHI-reimbursed. Pediatrics 
      (52.3%), rheumatology (14.0%) and hematology/oncology (11.4%) accounted for the 
      top three services in terms of IVIG consumption. Primary and secondary immune 
      deficiency (29.8%), Kawasaki disease (20.5%) and thrombocytopenia (16.8%) were 
      the top three indications. Neurological conditions only accounted for 3%. In 
      brief, unlike countries with high population use, the proportion of reimbursed 
      IVIG used for neurological conditions was low. Further studies on self-paid IVIG 
      use is needed to completely understand utilization in Taiwan.
CI  - Copyright (c) 2021 Formosan Medical Association. Published by Elsevier B.V. All 
      rights reserved.
FAU - Hsu, Ling-I
AU  - Hsu LI
AD  - Taiwan Blood Services Foundation, Taiwan.
FAU - Chen, Jen-Wen
AU  - Chen JW
AD  - Taiwan Blood Services Foundation, Taiwan.
FAU - Lin, Dong-Tsamn
AU  - Lin DT
AD  - Taiwan Blood Services Foundation, Taiwan.
FAU - Hung, Ying-Sheng
AU  - Hung YS
AD  - Taiwan Blood Services Foundation, Taiwan.
FAU - Hou, Sheng-Mou
AU  - Hou SM
AD  - Taiwan Blood Services Foundation, Taiwan; Shin Kong Wu Ho-Su Memorial Hospital, 
      Taiwan. Electronic address: hsu277@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20210313
PL  - Singapore
TA  - J Formos Med Assoc
JT  - Journal of the Formosan Medical Association = Taiwan yi zhi
JID - 9214933
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Child
MH  - Databases, Factual
MH  - Humans
MH  - *Immunoglobulins, Intravenous/therapeutic use
MH  - *Mucocutaneous Lymph Node Syndrome/drug therapy/epidemiology
MH  - Taiwan
OTO - NOTNLM
OT  - Intravenous immunoglobulin
OT  - National health insurance database
OT  - Taiwan
COIS- Conflicts of interest The authors declare that they have no conflicts of interest 
      relevant to the manuscript submitted to Journal of the Formosan Medical 
      Association.
EDAT- 2021/03/18 06:00
MHDA- 2021/09/21 06:00
CRDT- 2021/03/17 05:59
PHST- 2020/10/13 00:00 [received]
PHST- 2021/01/19 00:00 [revised]
PHST- 2021/02/21 00:00 [accepted]
PHST- 2021/03/18 06:00 [pubmed]
PHST- 2021/09/21 06:00 [medline]
PHST- 2021/03/17 05:59 [entrez]
AID - S0929-6646(21)00081-4 [pii]
AID - 10.1016/j.jfma.2021.02.017 [doi]
PST - ppublish
SO  - J Formos Med Assoc. 2021 Oct;120(10):1921-1925. doi: 10.1016/j.jfma.2021.02.017. 
      Epub 2021 Mar 13.