PMID- 33727099
OWN - NLM
STAT- MEDLINE
DCOM- 20211004
LR  - 20211004
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Linking)
VI  - 341
DP  - 2021 Jul
TI  - Role of TREM-1 in the development of early brain injury after subarachnoid 
      hemorrhage.
PG  - 113692
LID - S0014-4886(21)00097-2 [pii]
LID - 10.1016/j.expneurol.2021.113692 [doi]
AB  - Triggering receptor expressed on myeloid cells-1 (TREM-1) was found to be induced 
      in the context of subarachnoid hemorrhage (SAH) before. This study further 
      investigates its role in the development of SAH-induced early brain injury (EBI). 
      Firstly, rats were randomly divided into Sham and SAH groups for analysis of 
      temporal patterns and cellular localization of TREM-1. Secondly, TREM-1 
      intervention was administrated to produce Sham, vehicle, antagonist and agonist 
      groups, for analyzing TREM-1, Toll-like receptor 4 (TLR4), myeloid 
      differentiation factor 88 (MyD88) and NF-kappaB expressions at 24 h post-modeling, 
      and EBI assessment at 24 h and 72 h. Thirdly, TLR4 inhibitor (TAK-242) was 
      exploited to produce Sham, Sham+TAK-242, SAH, and SAH + TAK-242 groups to analyze 
      the effects of TLR4 inhibition on TREM-1 induction and EBI evaluation at 72 h. 
      Fourthly, the relationship of soluble TREM-1 (sTREM-1) levels in cerebrospinal 
      fluid of SAH patients with Hunt-Hess grades were explored. The results showed 
      that TREM-1 increased in the brain after experimental SAH (eSAH) early at 6 h and 
      peaked at 48 h, which was found to be located in microglia and endothelial cells. 
      TREM-1 inhibition attenuated EBI associated with TLR4/MyD88/NF-kappaB suppression, 
      while enhancement had the opposite effects. Contrarily, TLR4 inhibition prevented 
      TREM-1 induction and ameliorated EBI. In addition, sTREM-1 levels in SAH patients 
      positively correlated with Hunt-Hess grades. Overall, the present study provides 
      new evidence that TREM-1 increases dynamically in the brain after eSAH and it is 
      located in microglia and endothelial cells, which may aggravate EBI by 
      interacting with TLR4 pathway. And sTREM-1 in patients might act as a monitoring 
      biomarker of EBI, providing new insights for future studies.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Sun, Xin-Gang
AU  - Sun XG
AD  - Department of Neurology, the Second Hospital Affiliated to Shanxi Medical 
      University, Taiyuan, Shanxi 030000, People's Republic of China. Electronic 
      address: sunyanxia820701@163.com.
FAU - Zhang, Mi-Mi
AU  - Zhang MM
AD  - Shanxi Medical University, Taiyuan, Shanxi 030000, People's Republic of China.
FAU - Liu, Shao-Yu
AU  - Liu SY
AD  - Shanxi Medical University, Taiyuan, Shanxi 030000, People's Republic of China.
FAU - Chu, Xue-Hong
AU  - Chu XH
AD  - Shanxi Medical University, Taiyuan, Shanxi 030000, People's Republic of China.
FAU - Xue, Guo-Qiang
AU  - Xue GQ
AD  - Department of Neurosurgery, Yuncheng Hospital Affiliated to Shanxi Medical 
      University, Yuncheng, Shanxi 044000, People's Republic of China.
FAU - Zhang, Bao-Chen
AU  - Zhang BC
AD  - Department of Neurosurgery, Yuncheng Hospital Affiliated to Shanxi Medical 
      University, Yuncheng, Shanxi 044000, People's Republic of China.
FAU - Zhu, Jia-Bao
AU  - Zhu JB
AD  - Department of Neurosurgery, Yuncheng Hospital Affiliated to Shanxi Medical 
      University, Yuncheng, Shanxi 044000, People's Republic of China.
FAU - Godje Godje, Ivan Steve
AU  - Godje Godje IS
AD  - Shanxi Medical University, Taiyuan, Shanxi 030000, People's Republic of China.
FAU - Zhu, Li-Juan
AU  - Zhu LJ
AD  - Shanxi Medical University, Taiyuan, Shanxi 030000, People's Republic of China.
FAU - Hu, Hui-Yu
AU  - Hu HY
AD  - Shanxi Medical University, Taiyuan, Shanxi 030000, People's Republic of China.
FAU - Hai-Wang
AU  - Hai-Wang
AD  - Shanxi Medical University, Taiyuan, Shanxi 030000, People's Republic of China.
FAU - Shen, Ying-Jie
AU  - Shen YJ
AD  - Shanxi Medical University, Taiyuan, Shanxi 030000, People's Republic of China.
FAU - Wang, Gai-Qing
AU  - Wang GQ
AD  - Department of Neurology, the Second Hospital Affiliated to Shanxi Medical 
      University, Taiyuan, Shanxi 030000, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210313
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Triggering Receptor Expressed on Myeloid Cells-1)
SB  - IM
MH  - Aged
MH  - Animals
MH  - Blood-Brain Barrier/metabolism/pathology
MH  - Brain/metabolism/pathology
MH  - Brain Injuries/*metabolism/*pathology
MH  - Endothelial Cells/metabolism/pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Microglia/metabolism/pathology
MH  - Middle Aged
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Subarachnoid Hemorrhage/*metabolism/*pathology
MH  - Time Factors
MH  - Triggering Receptor Expressed on Myeloid Cells-1/*metabolism
OTO - NOTNLM
OT  - Early brain injury
OT  - MyD88
OT  - NF-kappaB
OT  - Subarachnoid hemorrhage
OT  - TLR4
OT  - TREM-1
EDAT- 2021/03/18 06:00
MHDA- 2021/10/05 06:00
CRDT- 2021/03/17 06:06
PHST- 2021/01/01 00:00 [received]
PHST- 2021/02/23 00:00 [revised]
PHST- 2021/03/11 00:00 [accepted]
PHST- 2021/03/18 06:00 [pubmed]
PHST- 2021/10/05 06:00 [medline]
PHST- 2021/03/17 06:06 [entrez]
AID - S0014-4886(21)00097-2 [pii]
AID - 10.1016/j.expneurol.2021.113692 [doi]
PST - ppublish
SO  - Exp Neurol. 2021 Jul;341:113692. doi: 10.1016/j.expneurol.2021.113692. Epub 2021 
      Mar 13.