PMID- 33727853
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220421
IS  - 1178-7058 (Print)
IS  - 1178-7058 (Electronic)
IS  - 1178-7058 (Linking)
VI  - 14
DP  - 2021
TI  - Structural and Functional Brain Changes in Hemodialysis Patients with End-Stage 
      Renal Disease: DTI Analysis Results and ALFF Analysis Results.
PG  - 77-86
LID - 10.2147/IJNRD.S295025 [doi]
AB  - INTRODUCTION: The current study aimed to depict intrinsic structural changes and 
      the spontaneous brain activity patterns in voxel level in patients with end-stage 
      renal disease (ESRD) undergoing hemodialysis (HD) by using diffusion-tensor 
      imaging and resting-state functional magnetic resonance (MR) imaging with an 
      amplitude of low-frequency fluctuations (ALFF) algorithm and their clinical 
      relevance. MATERIALS AND METHODS: In the study, the diffusion-tensor imaging and 
      resting-state functional MR imaging were performed in forty-two hemodialysis 
      patients with ESRD and 42 healthy control subjects. Neuropsychological and 
      laboratory tests were performed in all subjects. ALFF, fraction anisotropy (FA), 
      and mean diffusivity (MD) values were compared between the two groups. 
      Correlations between ALFF, FA or MD values, and clinical markers were analyzed. 
      RESULTS: We found that ESRD patients exhibited significantly lower ALFF values in 
      multiple areas, including medial frontal gyrus, limbic lobe, superior frontal 
      gyrus, bilateral lingual gyri, occipital lobe, parahippocampal gyrus, precuneus, 
      while increased ALFF values in medial frontal gyrus than healthy controls. FA 
      values were decreased in medial frontal gyrus, parietal lobe, and left precuneus 
      regions in the ESRD group compared with controls. Importantly, FA for the frontal 
      and parietal lobes was negatively associated with the dialysis duration of ESRD 
      patients, ALFF z-scores for the medial prefrontal cortex (MPFC) were positively 
      correlated with the dialysis duration of ESRD patients and Serum calcium of ESRD 
      patients negatively correlated with FA values in the frontal and parietal lobes 
      (p<0.05). CONCLUSION: Our study revealed that both impaired brain structure and 
      function in ESRD patients with routine hemodialysis distributed mainly in the 
      parietal, temporal, and frontal lobes. ESRD patients have cognitive impairment 
      and declined memory ability. Serum calcium and dialysis duration might be 
      associated with the impairment of brain structure and function in patients with 
      ESRD.
CI  - (c) 2021 Guo et al.
FAU - Guo, Huiying
AU  - Guo H
AUID- ORCID: 0000-0003-0968-3285
AD  - Department of Radiology, Second Affiliated Hospital of Nanjing Medical 
      University, Nanjing, Jiangsu, People's Republic of China.
FAU - Liu, Wenjin
AU  - Liu W
AD  - Center for Kidney Disease, Second Affiliated Hospital of Nanjing Medical 
      University, Nanjing, Jiangsu, People's Republic of China.
FAU - Li, Haige
AU  - Li H
AD  - Department of Radiology, Second Affiliated Hospital of Nanjing Medical 
      University, Nanjing, Jiangsu, People's Republic of China.
FAU - Yang, Junwei
AU  - Yang J
AD  - Center for Kidney Disease, Second Affiliated Hospital of Nanjing Medical 
      University, Nanjing, Jiangsu, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20210309
PL  - New Zealand
TA  - Int J Nephrol Renovasc Dis
JT  - International journal of nephrology and renovascular disease
JID - 101550217
PMC - PMC7955761
OTO - NOTNLM
OT  - cognitive impairment
OT  - diffusion-tensor imaging
OT  - end-stage renal disease
OT  - hemodialysis
OT  - resting-state functional MRI
COIS- The authors declare no competing financial interests and no conflicts of interest 
      in this work.
EDAT- 2021/03/18 06:00
MHDA- 2021/03/18 06:01
PMCR- 2021/03/09
CRDT- 2021/03/17 06:45
PHST- 2020/12/02 00:00 [received]
PHST- 2021/02/13 00:00 [accepted]
PHST- 2021/03/17 06:45 [entrez]
PHST- 2021/03/18 06:00 [pubmed]
PHST- 2021/03/18 06:01 [medline]
PHST- 2021/03/09 00:00 [pmc-release]
AID - 295025 [pii]
AID - 10.2147/IJNRD.S295025 [doi]
PST - epublish
SO  - Int J Nephrol Renovasc Dis. 2021 Mar 9;14:77-86. doi: 10.2147/IJNRD.S295025. 
      eCollection 2021.