PMID- 33729907
OWN - NLM
STAT- MEDLINE
DCOM- 20220301
LR  - 20220301
IS  - 1744-8409 (Electronic)
IS  - 1744-666X (Linking)
VI  - 17
IP  - 5
DP  - 2021 May
TI  - The use of nasal allergen vs allergen exposure chambers to evaluate allergen 
      immunotherapy.
PG  - 461-470
LID - 10.1080/1744666X.2021.1905523 [doi]
AB  - INTRODUCTION: Allergen-specific immunotherapy (AIT) is the only disease-modifying 
      treatment option for allergic rhinitis (AR) patients with persistent 
      moderate-severe AR for whom traditional pharmacotherapies are ineffective. The 
      nasal allergen challenge (NAC) and allergen exposure chamber (AEC) are two 
      translational models of AR that can be used to investigate the properties, 
      safety, and efficacy of AIT. AREAS COVERED: Peer-reviewed, human-centered 
      articles utilizing AEC or NAC models to investigate AIT between 2010 and 2020 
      were curated from PubMed, EMBASE, and OVID Medline databases. AECs have been used 
      to evaluate traditional subcutaneous and sublingual administrations of AIT, 
      including cross-protective effects and different dosing regimens. More recently, 
      the effectiveness of novel AIT formulations has been evaluated. NACs are another 
      model used to study AIT, including using novel intralymphatic routes of 
      administration. It is an especially powerful and versatile tool to determine if 
      basic science and animal model findings are clinically translatable. EXPERT 
      OPINION: The AEC and NAC models both produce clinically relevant and reproducible 
      results. AECs are more effective for studying many participants but are limited 
      because they require a specialized facility. As more AIT therapies and new 
      formulations are developed over time, the versatility of the NAC will be 
      especially useful.
FAU - Hossenbaccus, Lubnaa
AU  - Hossenbaccus L
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      Canada.
AD  - Allergy Research Unit, Kingston Health Sciences Centre - KGH Site, Kingston, 
      Canada.
FAU - Ellis, Anne K
AU  - Ellis AK
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      Canada.
AD  - Allergy Research Unit, Kingston Health Sciences Centre - KGH Site, Kingston, 
      Canada.
AD  - Department of Medicine, Queen's University, Kingston, Canada.
LA  - eng
PT  - Journal Article
DEP - 20210408
PL  - England
TA  - Expert Rev Clin Immunol
JT  - Expert review of clinical immunology
JID - 101271248
RN  - 0 (Allergens)
SB  - IM
MH  - Administration, Sublingual
MH  - *Allergens/therapeutic use
MH  - Animals
MH  - Desensitization, Immunologic/methods
MH  - Humans
MH  - Nasal Provocation Tests
MH  - *Rhinitis, Allergic/drug therapy
OTO - NOTNLM
OT  - Allergen immunotherapy
OT  - allergic rhinitis
OT  - environmental exposure chamber
OT  - nasal allergen challenge
EDAT- 2021/03/18 06:00
MHDA- 2022/03/03 06:00
CRDT- 2021/03/17 17:20
PHST- 2021/03/18 06:00 [pubmed]
PHST- 2022/03/03 06:00 [medline]
PHST- 2021/03/17 17:20 [entrez]
AID - 10.1080/1744666X.2021.1905523 [doi]
PST - ppublish
SO  - Expert Rev Clin Immunol. 2021 May;17(5):461-470. doi: 
      10.1080/1744666X.2021.1905523. Epub 2021 Apr 8.