PMID- 33730431
OWN - NLM
STAT- MEDLINE
DCOM- 20210817
LR  - 20210817
IS  - 1600-0714 (Electronic)
IS  - 0904-2512 (Linking)
VI  - 50
IP  - 7
DP  - 2021 Aug
TI  - Clinicopathological aspects of primary mucosa-associated lymphoid tissue lymphoma 
      of the salivary gland: A retrospective single-center analysis of 72 cases.
PG  - 723-730
LID - 10.1111/jop.13168 [doi]
AB  - BACKGROUND: Salivary gland extranodal marginal zone lymphoma of mucosa-associated 
      lymphoid tissue lymphoma (MALT lymphoma) is uncommon and has not been studied 
      extensively. We aimed to investigate the features of clinicopathological and 
      molecular changes of salivary MALT lymphoma. METHODS: Seventy-two cases of 
      primary salivary MALT lymphoma that had clinicopathological information available 
      were utilized in this study. MALT1 gene translocation, trisomy 3, and trisomy 18 
      were detected by interphase fluorescence in situ hybridization (FISH). The data 
      were analyzed using SPSS 17.0 software package. RESULTS: The ratio of male to 
      female was 1:2.8, and the median age was 57.0 years. 12.5% (9/72) of the patients 
      presented with multiple swellings. Among the others with solitary mass, the 
      parotid gland was involved most frequently (47/63,74.6%), followed by the palate 
      (7/63, 11.1%). 34.7% of patients had an autoimmune disease, with Sjogren syndrome 
      (SS) being the most common. Among the 70 cases successfully performed, it was 
      identified that trisomy 3 was the most frequent molecular change (41/70, 58.6%), 
      followed by trisomy 18 (7/70, 10%) and MALT1 translocation (5/70, 7.1%). The 
      tumor tissue tended to exhibit trisomy 3 in patients without SS (p = 0.038). The 
      5-year overall survival was 94.1%, and the 5-year disease-free survival was 85.3% 
      (mean follow-up time: 104.7 months). The patients without SS and trisomy 18 had a 
      prolonged recurrence-free survival (p = 0.015, p = 0.001 respectively). 
      CONCLUSION: Salivary gland MALT lymphoma is associated with autoimmune diseases, 
      and trisomy 3 is the most common genetic change. Trisomy 18 can be used to 
      predict the possibility of tumor relapse.
CI  - (c) 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Zhang, Chunye
AU  - Zhang C
AD  - Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of 
      Stomatology, Department of Oral Pathology, College of Stomatology, Shanghai Jiao 
      Tong University School of Medicine, National Clinical Research Center for Oral 
      Disease, Shanghai Ninth People's Hospital, Shanghai, China.
FAU - Xia, Ronghui
AU  - Xia R
AD  - Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of 
      Stomatology, Department of Oral Pathology, College of Stomatology, Shanghai Jiao 
      Tong University School of Medicine, National Clinical Research Center for Oral 
      Disease, Shanghai Ninth People's Hospital, Shanghai, China.
FAU - Gu, Ting
AU  - Gu T
AD  - Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of 
      Stomatology, Department of Oral Pathology, College of Stomatology, Shanghai Jiao 
      Tong University School of Medicine, National Clinical Research Center for Oral 
      Disease, Shanghai Ninth People's Hospital, Shanghai, China.
FAU - Wang, Lizhen
AU  - Wang L
AD  - Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of 
      Stomatology, Department of Oral Pathology, College of Stomatology, Shanghai Jiao 
      Tong University School of Medicine, National Clinical Research Center for Oral 
      Disease, Shanghai Ninth People's Hospital, Shanghai, China.
FAU - Tian, Zhen
AU  - Tian Z
AD  - Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of 
      Stomatology, Department of Oral Pathology, College of Stomatology, Shanghai Jiao 
      Tong University School of Medicine, National Clinical Research Center for Oral 
      Disease, Shanghai Ninth People's Hospital, Shanghai, China.
FAU - Zhu, Ling
AU  - Zhu L
AD  - Department of Radiology, Shanghai Ninth People's Hospital, Shanghai, China.
FAU - Han, Jing
AU  - Han J
AD  - Department of Oral and Maxillofacial-Head and Neck Oncology, College of 
      Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University 
      School of Medicine, Shanghai, China.
FAU - Hu, Yuhua
AU  - Hu Y
AD  - Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of 
      Stomatology, Department of Oral Pathology, College of Stomatology, Shanghai Jiao 
      Tong University School of Medicine, National Clinical Research Center for Oral 
      Disease, Shanghai Ninth People's Hospital, Shanghai, China.
FAU - Wang, Yu
AU  - Wang Y
AD  - Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of 
      Stomatology, Department of Oral Pathology, College of Stomatology, Shanghai Jiao 
      Tong University School of Medicine, National Clinical Research Center for Oral 
      Disease, Shanghai Ninth People's Hospital, Shanghai, China.
FAU - Sun, Jingjing
AU  - Sun J
AUID- ORCID: 0000-0002-3087-8258
AD  - Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of 
      Stomatology, Department of Oral Pathology, College of Stomatology, Shanghai Jiao 
      Tong University School of Medicine, National Clinical Research Center for Oral 
      Disease, Shanghai Ninth People's Hospital, Shanghai, China.
FAU - Li, Jiang
AU  - Li J
AUID- ORCID: 0000-0002-8856-5772
AD  - Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of 
      Stomatology, Department of Oral Pathology, College of Stomatology, Shanghai Jiao 
      Tong University School of Medicine, National Clinical Research Center for Oral 
      Disease, Shanghai Ninth People's Hospital, Shanghai, China.
LA  - eng
GR  - 81872187/The National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20210329
PL  - Denmark
TA  - J Oral Pathol Med
JT  - Journal of oral pathology & medicine : official publication of the International 
      Association of Oral Pathologists and the American Academy of Oral Pathology
JID - 8911934
SB  - IM
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Lymphoma, B-Cell, Marginal Zone/genetics
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local
MH  - Retrospective Studies
MH  - Salivary Glands
OTO - NOTNLM
OT  - MALT lymphoma
OT  - genetic change
OT  - salivary gland
EDAT- 2021/03/18 06:00
MHDA- 2021/08/18 06:00
CRDT- 2021/03/17 17:54
PHST- 2021/01/27 00:00 [revised]
PHST- 2020/09/02 00:00 [received]
PHST- 2021/02/23 00:00 [accepted]
PHST- 2021/03/18 06:00 [pubmed]
PHST- 2021/08/18 06:00 [medline]
PHST- 2021/03/17 17:54 [entrez]
AID - 10.1111/jop.13168 [doi]
PST - ppublish
SO  - J Oral Pathol Med. 2021 Aug;50(7):723-730. doi: 10.1111/jop.13168. Epub 2021 Mar 
      29.