PMID- 33730750
OWN - NLM
STAT- MEDLINE
DCOM- 20210608
LR  - 20210608
IS  - 0300-0729 (Print)
IS  - 0300-0729 (Linking)
VI  - 59
IP  - 3
DP  - 2021 Jun 1
TI  - Matrix metalloproteinases and chronic rhinosinusitis with nasal polyposis. 
      Unravelling a puzzle through a systematic review.
PG  - 245-257
LID - 10.4193/Rhin20.578 [doi]
AB  - BACKGROUND: The expression of metalloproteinases (MMPs) in chronic rhinosinusitis 
      with nasal polyposis (CRSwNP) was reviewed in order to investigate their possible 
      use as therapeutical targets and/or biomarkers. METHODOLOGY: The differences 
      between CRSwNP and normal controls or CRS without NP, as well as the effects of 
      various treatments on MMPs, tissue inhibitors of MMPs (TIMPs) and MMP/TIMP ratios 
      were considered as primary outcomes. Additional factors reported to affect MMP 
      expression levels were noted as secondary outcomes. Data regarding inflammatory 
      subtypes, patientsaeuro clinical characteristics, controls, laboratory method(s) 
      and origin of samples were also pooled. Studies on 10 or fewer patients or on 
      specimens other than nasal and serum were excluded. RESULTS: Forty-three studies 
      were included. Tissue sample origin, allergic rhinitis, smoking, infection, 
      medication intake and primary or recurrent disease should be considered as 
      confounding factors for MMP levels. MMP-1 and -7 were consistently found to be 
      significantly higher in CRSwNP patients than controls. CRSwNP endotypes with 
      distinctly different inflammation patterns seem to present similar MMP-related 
      remodelling patterns. CONCLUSIONS: The existing literature has revealed several 
      population and methodology related confounding factors and remains inconclusive 
      regarding the roles of MMPs in CRSwNP pathophysiology and their possible clinical 
      usefulness as biomarkers and therapeutical targets.
FAU - Lygeros, S
AU  - Lygeros S
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, University of Patras, 
      Medical School, Patras, Greece.
FAU - Danielides, G
AU  - Danielides G
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, University of Patras, 
      Medical School, Patras, Greece.
FAU - Grafanaki, K
AU  - Grafanaki K
AD  - Department of Biochemistry and Department of Dermatology School of Medicine, 
      University of Patras, Greece.
FAU - Riga, M
AU  - Riga M
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Dammam Medical Complex, 
      Dammam, Kingdom of Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
PL  - Netherlands
TA  - Rhinology
JT  - Rhinology
JID - 0347242
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Chronic Disease
MH  - Humans
MH  - Matrix Metalloproteinases
MH  - Nasal Mucosa/pathology
MH  - *Nasal Polyps/pathology
MH  - *Rhinitis/pathology
MH  - *Sinusitis/pathology
EDAT- 2021/03/18 06:00
MHDA- 2021/06/09 06:00
CRDT- 2021/03/17 20:20
PHST- 2021/03/18 06:00 [pubmed]
PHST- 2021/06/09 06:00 [medline]
PHST- 2021/03/17 20:20 [entrez]
AID - 2758 [pii]
AID - 10.4193/Rhin20.578 [doi]
PST - ppublish
SO  - Rhinology. 2021 Jun 1;59(3):245-257. doi: 10.4193/Rhin20.578.
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