PMID- 33733642
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210502
IS  - 2092-7355 (Print)
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Linking)
VI  - 13
IP  - 3
DP  - 2021 May
TI  - Elevated MRGPRX2 Levels Related to Disease Severity in Patients With Chronic 
      Spontaneous Urticaria.
PG  - 498-506
LID - 10.4168/aair.2021.13.3.498 [doi]
AB  - Mas-related G-protein coupled receptor-X2 (MRGPRX2), a receptor on mast cells, 
      basophils, and eosinophils associated with immunoglobulin E (IgE)-independent 
      degranulation, has been reported to be highly expressed on cutaneous mast cells 
      in patients with severe chronic spontaneous urticaria (CSU). We sought to 
      investigate whether MRGPRX2 levels in the sera from CSU patients differ from 
      those in healthy control subjects and to evaluate the clinical utility of MRGPRX2 
      levels in CSU patients. Severe CSU was defined as urticaria activity score over 7 
      days (UAS7) >/= 28. Serum samples from 116 (73 severe and 43 non-severe) CSU 
      patients and 50 healthy subjects were screened for MRGPRX2 using enzyme-linked 
      immunosorbent assay. Serum MRGPRX2 levels were significantly higher in patients 
      with severe CSU (median [interquartile range], 16.5 [10.8-24.8]) than in healthy 
      controls (11.7 [6.5-21.2], P = 0.036) and in non-severe CSU patients (8.7 
      [4.5-18.8], P = 0.002), although they did not differ between healthy subjects and 
      non-severe CSU patients. Serum MRGPRX2 levels in CSU patients showed positive 
      correlations with UAS7 and specific IgE against Dermatophagoides farinae in CSU 
      subjects, whereas no correlations were observed for age, sex, urticaria duration, 
      atopy, combined angioedema, autologous serum skin test positivity, or total IgE 
      levels. Logistic regression analysis identified serum MRGPRX2 >/= 12 ng/mL (odds 
      ratio, 6.421; P = 0.002) as an independent risk factor for severe CSU, along with 
      increased serum total IgE levels, peripheral basophil percentage, and angioedema. 
      In conclusion, we suggest that serum MRGPRX2 could help indicate severe CSU.
CI  - Copyright (c) 2021 The Korean Academy of Asthma, Allergy and Clinical Immunology . 
      The Korean Academy of Pediatric Allergy and Respiratory Disease.
FAU - Cao, Thi Bich Tra
AU  - Cao TBT
AUID- ORCID: 0000-0003-4459-6486
AD  - Department of Biomedical Science, Ajou University School of Medicine, Suwon, 
      Korea.
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Korea.
FAU - Cha, Hyun Young
AU  - Cha HY
AUID- ORCID: 0000-0001-8453-7347
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Korea.
FAU - Yang, Eun Mi
AU  - Yang EM
AUID- ORCID: 0000-0001-8371-3513
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Korea.
FAU - Ye, Young Min
AU  - Ye YM
AUID- ORCID: 0000-0002-7517-1715
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Korea. ye9007@ajou.ac.kr.
LA  - eng
GR  - NRF-2018R1A2B6006199/NRF/National Research Foundation of Korea/Korea
GR  - HI16C0992/Korea Health Industry Development Institute/Republic of Korea
PT  - Journal Article
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC7984951
OTO - NOTNLM
OT  - Chronic urticaria
OT  - Disease severity
OT  - MRGPRX2
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2021/03/19 06:00
MHDA- 2021/03/19 06:01
PMCR- 2021/05/01
CRDT- 2021/03/18 07:17
PHST- 2020/07/09 00:00 [received]
PHST- 2020/08/26 00:00 [revised]
PHST- 2020/09/19 00:00 [accepted]
PHST- 2021/03/18 07:17 [entrez]
PHST- 2021/03/19 06:00 [pubmed]
PHST- 2021/03/19 06:01 [medline]
PHST- 2021/05/01 00:00 [pmc-release]
AID - 13.498 [pii]
AID - 10.4168/aair.2021.13.3.498 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2021 May;13(3):498-506. doi: 
      10.4168/aair.2021.13.3.498.