PMID- 33734028
OWN - NLM
STAT- MEDLINE
DCOM- 20211105
LR  - 20220716
IS  - 1758-8936 (Electronic)
IS  - 1758-8928 (Print)
IS  - 1758-8928 (Linking)
VI  - 12
IP  - 3-4
DP  - 2021 Jul-Oct
TI  - Sex differences in functional network dynamics observed using coactivation 
      pattern analysis.
PG  - 120-130
LID - 10.1080/17588928.2021.1880383 [doi]
AB  - Sex differences in the organization of large-scale resting-state brain networks 
      have been identified using traditional static measures, which average functional 
      connectivity over extended time periods. In contrast, emerging dynamic measures 
      have the potential to define sex differences in network changes over time, 
      providing additional understanding of neurobiological sex differences. To meet 
      this goal, we used a Coactivation Pattern Analysis (CAP) using resting-state 
      functional magnetic resonance imaging data from 181 males and 181 females from 
      the Human Connectome Project. Significant main effects of sex were observed 
      across two independent imaging sessions. Relative to males, females spent more 
      total time in two transient network states (TNSs) spatially overlapping with the 
      dorsal attention network and occipital/sensory-motor network. Greater time spent 
      in these TNSs was related to females making more frequent transitions into these 
      TNSs compared to males. In contrast, males spent more total time in TNSs 
      spatially overlapping with the salience network, which was related to males 
      staying for longer periods once entering these TNSs compared to females. 
      State-to-state transitions also significantly differed between sexes: females 
      transitioned more frequently from default mode network (DMN) states to the dorsal 
      attention network state, whereas males transitioned more frequently from DMN 
      states to salience network states. Results show that males and females spend 
      differing amounts of time at rest in two distinct attention-related networks and 
      show sex-specific transition patterns from DMN states into these 
      attention-related networks. This work lays the groundwork for future 
      investigations into the cognitive and behavioral implications of these 
      sex-specific network dynamics.
FAU - Murray, Laura
AU  - Murray L
AUID- ORCID: 0000-0001-8409-4697
AD  - McLean Imaging Center, McLean Hospital, Belmont, Massachusetts, USA.
AD  - Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
FAU - Maurer, J Michael
AU  - Maurer JM
AD  - McLean Imaging Center, McLean Hospital, Belmont, Massachusetts, USA.
AD  - Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
AD  - Mind Research Network, Albuquerque, New Mexico, USA.
FAU - Peechatka, Alyssa L
AU  - Peechatka AL
AD  - McLean Imaging Center, McLean Hospital, Belmont, Massachusetts, USA.
AD  - Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
FAU - Frederick, Blaise B
AU  - Frederick BB
AD  - McLean Imaging Center, McLean Hospital, Belmont, Massachusetts, USA.
AD  - Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
FAU - Kaiser, Roselinde H
AU  - Kaiser RH
AD  - Department of Psychology and Neuroscience, University of Colorado Boulder, 
      Boulder, Colorado, USA.
FAU - Janes, Amy C
AU  - Janes AC
AD  - McLean Imaging Center, McLean Hospital, Belmont, Massachusetts, USA.
AD  - Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
LA  - eng
GR  - K02 DA042987/DA/NIDA NIH HHS/United States
GR  - R01 NS097512/NS/NINDS NIH HHS/United States
GR  - T32 DA015036/DA/NIDA NIH HHS/United States
GR  - UL1 TR002541/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20210318
PL  - England
TA  - Cogn Neurosci
JT  - Cognitive neuroscience
JID - 101518151
SB  - IM
MH  - Brain/diagnostic imaging
MH  - *Connectome
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Sex Characteristics
PMC - PMC8448790
MID - NIHMS1667276
OTO - NOTNLM
OT  - Sex differences
OT  - coactivation pattern analysis
OT  - functional magnetic resonance imaging
OT  - functional network dynamics
OT  - human connectome project
OT  - resting-state
EDAT- 2021/03/19 06:00
MHDA- 2021/11/06 06:00
PMCR- 2022/07/01
CRDT- 2021/03/18 12:32
PHST- 2021/03/19 06:00 [pubmed]
PHST- 2021/11/06 06:00 [medline]
PHST- 2021/03/18 12:32 [entrez]
PHST- 2022/07/01 00:00 [pmc-release]
AID - 10.1080/17588928.2021.1880383 [doi]
PST - ppublish
SO  - Cogn Neurosci. 2021 Jul-Oct;12(3-4):120-130. doi: 10.1080/17588928.2021.1880383. 
      Epub 2021 Mar 18.