PMID- 33734630
OWN - NLM
STAT- MEDLINE
DCOM- 20210405
LR  - 20210405
IS  - 1565-1088 (Print)
VI  - 23
IP  - 3
DP  - 2021 Mar
TI  - C-Reactive Protein Velocity and the Risk of New Onset Atrial Fibrillation among 
      ST Elevation Myocardial Infarction Patients.
PG  - 169-173
AB  - BACKGROUND: Elevated C-reactive protein (CRP) was shown to be associated with an 
      increased risk for new-onset atrial fibrillation (AF) in ST elevation myocardial 
      infarction (STEMI) patients undergoing primary percutaneous coronary intervention 
      (PCI); however, the optimal time frame to measure CRP for risk stratification is 
      not known. OBJECTIVES: To evaluate the relation between the change in CRP over 
      time (CRP velocity [CRPv]) and new-onset AF among STEMI patients treated with 
      primary PCI. METHODS: We included 801 STEMI patients who underwent PCI between 
      2007 and 2017 and had their CRP measured with a wide range assay (wr-CRP) at 
      least twice during the 24 hours after admission. CRPv was defined as the change 
      in wr-CRP concentration (mg/l) divided by the change in time (in hours) between 
      the two measurements. Patient medical records were reviewed for occurrence of 
      new-onset AF. RESULTS: New onset AF occurred in 45 patients (6%). Patients with 
      new onset AF had significantly higher median CRPv (1.27 vs. 0.43 mg/l/h, P = 
      0.002). New-onset AF during hospitalization occurred in 3.4%, 4.5 %, and 9.1% of 
      patients in the first, second and third CRPv tertiles, respectively (P for trend 
      = 0.006). In a multivariable logistic regression, adjusting for clinical 
      variables the odds ratios for new onset AF was 1.93 (95% confidence interval 
      1.0-3.59, P = 0.04) for patients in the third CRPv tertile. CONCLUSIONS: CRPv 
      might be an independent and rapidly measurable biomarker for new-onset AF 
      following primary PCI in STEMI patients.
FAU - Zahler, David
AU  - Zahler D
AD  - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the 
      Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Merdler, Ilan
AU  - Merdler I
AD  - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the 
      Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Rozenfeld, Keren-Lee
AU  - Rozenfeld KL
AD  - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the 
      Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Shenberg, Gil
AU  - Shenberg G
AD  - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the 
      Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of 
      Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the Sackler Faculty 
      of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Milwidsky, Assi
AU  - Milwidsky A
AD  - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the 
      Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Berliner, Shlomo
AU  - Berliner S
AD  - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the 
      Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Banai, Shmuel
AU  - Banai S
AD  - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the 
      Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Arbel, Yaron
AU  - Arbel Y
AD  - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the 
      Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Shacham, Yacov
AU  - Shacham Y
AD  - Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the 
      Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - Israel
TA  - Isr Med Assoc J
JT  - The Israel Medical Association journal : IMAJ
JID - 100930740
RN  - 0 (Biomarkers)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Atrial Fibrillation/*blood/diagnosis/*etiology
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*metabolism
MH  - Female
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Percutaneous Coronary Intervention
MH  - Retrospective Studies
MH  - ST Elevation Myocardial Infarction/*blood/*complications/therapy
MH  - Time Factors
EDAT- 2021/03/19 06:00
MHDA- 2021/04/07 06:00
CRDT- 2021/03/18 13:05
PHST- 2021/03/18 13:05 [entrez]
PHST- 2021/03/19 06:00 [pubmed]
PHST- 2021/04/07 06:00 [medline]
PST - ppublish
SO  - Isr Med Assoc J. 2021 Mar;23(3):169-173.