PMID- 33735038 OWN - NLM STAT- Publisher LR - 20240222 IS - 2530-3120 (Electronic) IS - 2530-3120 (Linking) DP - 2021 Jan 4 TI - Functionality During the First Five Years After the Diagnosis of Schizophrenia. A Cohort Study in a Colombian Population. LID - S0034-7450(20)30117-7 [pii] LID - 10.1016/j.rcp.2020.11.005 [doi] AB - OBJECTIVE: There is a lack of studies on the natural history of the initial stages of schizophrenia in Colombia. This study aims to assess functionality in the first five years after the diagnosis of schizophrenia. METHODS: Naturalistic longitudinal study of 50 patients with early schizophrenia evaluated between 2011 and 2014. Data about demographic background, symptoms, introspection, treatment and adverse reactions were collected in all patients every 3 months for at least 3-5 years. Functionality was measured with the Global Assessment of Functioning (GAF) and Personal and Social Performance (PSP) scales. RESULTS: Patients were followed up for a mean of 174+/-62.5 weeks and showed moderate difficulties in overall functioning. This functioning was modified by polypharmacy, degree of introspection, changes in antipsychotic regimens, and the number of episodes, relapses and hospitalisations. CONCLUSIONS: The results suggest that functional outcomes seem to be related to the use of polypharmacy, degree of insight, changes in antipsychotic regimens, and number of episodes, relapses and hospitalisations during the first years of schizophrenia. CI - Copyright (c) 2020 Asociacion Colombiana de Psiquiatria. Publicado por Elsevier Espana, S.L.U. All rights reserved. FAU - Cano, Juan F AU - Cano JF AD - UR Center for Mental Health (CeRSaMe), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia; Centro de Investigaciones del Sistema Nervioso (CISNE), Bogota, Colombia. Electronic address: juanf.cano@urosario.edu.co. FAU - Ortegon-Valencia, Julian AU - Ortegon-Valencia J AD - Centro de Investigaciones del Sistema Nervioso (CISNE), Bogota, Colombia. FAU - Pedraza-Perez, Carlos AU - Pedraza-Perez C AD - Centro de Investigaciones del Sistema Nervioso (CISNE), Bogota, Colombia. FAU - Cordoba-Rojas, Rodrigo AU - Cordoba-Rojas R AD - UR Center for Mental Health (CeRSaMe), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia; Centro de Investigaciones del Sistema Nervioso (CISNE), Bogota, Colombia. FAU - Olarte-Armenta, Ana AU - Olarte-Armenta A AD - Centro de Investigaciones del Sistema Nervioso (CISNE), Bogota, Colombia. FAU - Vallejo-Silva, Alexie AU - Vallejo-Silva A AD - UR Center for Mental Health (CeRSaMe), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia; Clinica Nuestra Senora de la Paz, Bogota, Colombia. FAU - Gonzalez-Diaz, Jairo AU - Gonzalez-Diaz J AD - UR Center for Mental Health (CeRSaMe), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia; Clinica Nuestra Senora de la Paz, Bogota, Colombia. LA - eng LA - spa PT - Journal Article DEP - 20210104 PL - Spain TA - Rev Colomb Psiquiatr (Engl Ed) JT - Revista Colombiana de psiquiatria (English ed.) JID - 101778593 SB - IM OTO - NOTNLM OT - Antipsicoticos OT - Antipsychotics OT - Colombia OT - Esquizofrenia OT - Funcionalidad OT - Functioning OT - Introspeccion OT - Introspection OT - Recurrence OT - Recurrencia OT - Schizophrenia EDAT- 2021/03/19 06:00 MHDA- 2021/03/19 06:00 CRDT- 2021/03/18 17:25 PHST- 2020/03/16 00:00 [received] PHST- 2020/08/18 00:00 [revised] PHST- 2020/11/02 00:00 [accepted] PHST- 2021/03/18 17:25 [entrez] PHST- 2021/03/19 06:00 [pubmed] PHST- 2021/03/19 06:00 [medline] AID - S0034-7450(20)30117-7 [pii] AID - 10.1016/j.rcp.2020.11.005 [doi] PST - aheadofprint SO - Rev Colomb Psiquiatr (Engl Ed). 2021 Jan 4:S0034-7450(20)30117-7. doi: 10.1016/j.rcp.2020.11.005.