PMID- 33735587
OWN - NLM
STAT- MEDLINE
DCOM- 20210823
LR  - 20210823
IS  - 1097-9891 (Electronic)
IS  - 0095-2990 (Linking)
VI  - 47
IP  - 3
DP  - 2021 May 4
TI  - Neural responses to negative events and subsequent persistence behavior differ in 
      individuals recovering from opioid use disorder compared to controls.
PG  - 319-329
LID - 10.1080/00952990.2021.1888960 [doi]
AB  - Background: Negative emotion is associated with substance craving and use in 
      individuals recovering from substance use disorders, including prescription 
      opioid use disorder (POUD). Decisions to abandon or persist towards a goal after 
      negative emotion-eliciting events, and neural responses that shape such 
      decisions, may be important in maintaining recovery from POUD.Objectives: We 
      examined differences in neural responses to negative events and subsequent 
      persistence decisions in individuals recovering from POUD without a history of a 
      substance use disorder. Methods: 20 individuals with POUD (POUD group: 4 females, 
      abstinent 2-3 weeks after admission to an inpatient treatment facility 
      post-detoxification, no other substance use disorder), and 20 individuals with no 
      substance use history (control group: 6 females) completed a 
      persistence-after-setbacks task during functional magnetic resonance imaging. 
      Participants advanced along a path toward a reward; after encountering each 
      negative event (i.e., progress-erasing setback), participants made decisions to 
      persist or abandon the path. Persistence decision rates were compared between 
      groups and blood-oxygen-level-dependent signal to negative events was analyzed 
      within a striatum region of interest (ROI) as well as whole-brain.Results: The 
      POUD group persisted less (t(38) = 2.293, p = .028, d = .725) and showed lower 
      striatum (left ventral putamen) signal to negative events compared to the control 
      group (p < .05, corrected for striatum ROI).Conclusions: In POUD, neural and 
      behavioral responses to negative events differ from controls. These differences 
      are a target for research to address whether POUD treatment increases persistence 
      and striatum responses to negative events and improves recovery outcomes.
FAU - Bhanji, Jamil P
AU  - Bhanji JP
AUID- ORCID: 0000-0003-3451-8732
AD  - Department of Psychology, Rutgers University, Newark, NJ, USA.
FAU - Delgado, Mauricio R
AU  - Delgado MR
AD  - Department of Psychology, Rutgers University, Newark, NJ, USA.
FAU - Ray, Suchismita
AU  - Ray S
AD  - Department of Health Informatics, Rutgers School of Health Professions, Rutgers 
      University, Newark, NJ, USA.
LA  - eng
GR  - R03 DA044496/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20210318
PL  - England
TA  - Am J Drug Alcohol Abuse
JT  - The American journal of drug and alcohol abuse
JID - 7502510
SB  - IM
MH  - Adult
MH  - Affect/*physiology
MH  - Brain/physiopathology
MH  - Brain Mapping
MH  - Case-Control Studies
MH  - Craving
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - New Jersey
MH  - Opioid-Related Disorders/*physiopathology
MH  - Young Adult
OTO - NOTNLM
OT  - Addiction
OT  - affect
OT  - aversive
OT  - decision
OT  - emotion
OT  - fmri
OT  - persistence
OT  - striatum
EDAT- 2021/03/19 06:00
MHDA- 2021/08/24 06:00
CRDT- 2021/03/18 20:09
PHST- 2021/03/19 06:00 [pubmed]
PHST- 2021/08/24 06:00 [medline]
PHST- 2021/03/18 20:09 [entrez]
AID - 10.1080/00952990.2021.1888960 [doi]
PST - ppublish
SO  - Am J Drug Alcohol Abuse. 2021 May 4;47(3):319-329. doi: 
      10.1080/00952990.2021.1888960. Epub 2021 Mar 18.