PMID- 33736747
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20220531
IS  - 1469-8730 (Electronic)
IS  - 0967-1994 (Linking)
VI  - 29
IP  - 5
DP  - 2021 Oct
TI  - Circulating MMP-7 and VEGF as potential predictive biomarkers for recurrent 
      implantation failures.
PG  - 365-371
LID - 10.1017/S0967199421000113 [doi]
AB  - Recurrent implantation failure (RIF) is considered to be one of the major 
      limiting factors of assisted reproductive technology (ART) programme success. The 
      current study focused on the investigation of matrix metalloproteinases (MMPs), 
      tissue inhibitors of MMPs (TIMPs), cytokines and cell adhesion molecules in 
      peripheral blood (PB) and follicular fluid (FF) obtained from 44 women aged 
      between 25 and 39 years old and undergoing intracytoplasmic sperm injection 
      (ICSI). These women were divided into two groups: 22 RIF women with embryo 
      implantation failures after the transfer of at least four fresh or frozen-thawed 
      good quality embryos in a minimum of three ICSI cycles, and 22 ICSI success women 
      (controls) who achieved a clinical pregnancy at their first ICSI attempt. The PB 
      and FF samples were obtained from each patient on the day of oocyte retrieval. 
      MMP-1, -2, -3, -7, -9, TIMP-1, -2, vascular endothelial growth factor (VEGF), 
      leukaemia inhibitory factor (LIF), vascular cell adhesion molecule 1 (VCAM1) and 
      intercellular adhesion molecules 1 (ICAM1) were analyzed using enzyme-linked 
      immunosorbent assay of PB and FF. Our results showed significant decreases in PB 
      MMP-7 and PB VEGF in the RIF group compared with controls [281.11 (33-614) pg/ml 
      vs 119.92 (27-441) pg/ml; P-value = 0.030] and [82.54 (25.94-210.20) pg/ml vs 
      30.93 (13.62-193.33) pg/ml; P-value = 0.022; respectively]. Receiver operating 
      characteristic (ROC) curve analysis showed informative area under the curve 
      values for PB MMP-7, as well as for PB VEGF, making them able to be proposed as 
      biomarkers of the RIF. Therefore, circulating MMP-7 and VEGF seem to play an 
      interesting role in embryo implantation in in vitro fertilization (IVF)/ICSI 
      cycles and could be proposed as circulating biomarkers of the RIF. These results 
      could be helpful for clinicians and patients to choose the best rescue strategy 
      and treatment to minimize implantation failure in women undergoing IVF/ICSI 
      procedures after the first attempt.
FAU - Benkhalifa, Mustapha
AU  - Benkhalifa M
AD  - LR99ES11, Department of Biochemistry, La Rabta Hospital, Faculty of Medicine of 
      Tunis, University of Tunis El Manar, Tunis, Tunisia.
AD  - Faculty of Sciences of Bizerte, University of Carthage, Tunis, Tunisia.
FAU - Zidi, Wiem
AU  - Zidi W
AD  - LR99ES11, Department of Biochemistry, La Rabta Hospital, Faculty of Medicine of 
      Tunis, University of Tunis El Manar, Tunis, Tunisia.
AD  - Faculty of Sciences of Bizerte, University of Carthage, Tunis, Tunisia.
FAU - Bahri, Hatem
AU  - Bahri H
AD  - Alyssa Fertility Group Center, Alyssa Clinic, Les Berges du Lac, Tunis, Tunisia.
FAU - Mahjoub, Sami
AU  - Mahjoub S
AD  - Alyssa Fertility Group Center, Alyssa Clinic, Les Berges du Lac, Tunis, Tunisia.
FAU - Boudhraa, Khaled
AU  - Boudhraa K
AD  - Alyssa Fertility Group Center, Alyssa Clinic, Les Berges du Lac, Tunis, Tunisia.
FAU - Sanhaji, Haifa
AU  - Sanhaji H
AD  - LR99ES11, Department of Biochemistry, La Rabta Hospital, Faculty of Medicine of 
      Tunis, University of Tunis El Manar, Tunis, Tunisia.
FAU - Khorsi-Cauet, Hafida
AU  - Khorsi-Cauet H
AD  - PERITOX-UMR-I 01 CURS, Picardie University Jules Verne, Amiens, France.
FAU - Feki, Moncef
AU  - Feki M
AD  - LR99ES11, Department of Biochemistry, La Rabta Hospital, Faculty of Medicine of 
      Tunis, University of Tunis El Manar, Tunis, Tunisia.
FAU - Benkhalifa, Moncef
AU  - Benkhalifa M
AUID- ORCID: 0000-0002-3382-989X
AD  - PERITOX-UMR-I 01 CURS, Picardie University Jules Verne, Amiens, France.
AD  - Reproductive Medicine, Reproductive Biology and Genetics, University Hospital and 
      School of Medicine Picardie University Jules Verne, Amiens, France.
FAU - Allal-Elasmi, Monia
AU  - Allal-Elasmi M
AUID- ORCID: 0000-0002-5325-6347
AD  - LR99ES11, Department of Biochemistry, La Rabta Hospital, Faculty of Medicine of 
      Tunis, University of Tunis El Manar, Tunis, Tunisia.
LA  - eng
PT  - Journal Article
DEP - 20210319
PL  - England
TA  - Zygote
JT  - Zygote (Cambridge, England)
JID - 9309124
RN  - 0 (Biomarkers)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - EC 3.4.24.23 (MMP7 protein, human)
RN  - EC 3.4.24.23 (Matrix Metalloproteinase 7)
SB  - IM
MH  - Adult
MH  - Biomarkers
MH  - Embryo Implantation
MH  - Female
MH  - Fertilization in Vitro
MH  - Humans
MH  - *Matrix Metalloproteinase 7
MH  - Pregnancy
MH  - Pregnancy Rate
MH  - Sperm Injections, Intracytoplasmic
MH  - *Vascular Endothelial Growth Factor A
OTO - NOTNLM
OT  - Assisted reproductive technology
OT  - Matrilysin
OT  - Matrix metalloproteinases
OT  - Recurrent implantation failure
OT  - Vascular endothelial growth factor
EDAT- 2021/03/20 06:00
MHDA- 2021/10/16 06:00
CRDT- 2021/03/19 05:55
PHST- 2021/03/20 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2021/03/19 05:55 [entrez]
AID - S0967199421000113 [pii]
AID - 10.1017/S0967199421000113 [doi]
PST - ppublish
SO  - Zygote. 2021 Oct;29(5):365-371. doi: 10.1017/S0967199421000113. Epub 2021 Mar 19.