PMID- 3373722
OWN - NLM
STAT- MEDLINE
DCOM- 19880630
LR  - 20190817
IS  - 0047-1828 (Print)
IS  - 0047-1828 (Linking)
VI  - 52
IP  - 3
DP  - 1988 Mar
TI  - Therapeutic effectiveness and plasma levels of single or combination use of class 
      I antiarrhythmic agents for ventricular arrhythmias.
PG  - 298-305
AB  - The efficacy of disopyramide (DP), mexiletine (MX), aprindine (AP) and 
      cibenzoline (CZ) on ventricular arrhythmias was compared (single drug therapy). 
      In addition, the efficacy of the combination therapy of DP with MX was also 
      studied (combination therapy). One hundred of the 106 patients completed the 
      protocol of the single drug therapy. Fifty percent or more reduction in the 
      frequency of ventricular premature contractions (VPCs) was obtained in 24 of 43 
      patients (56%) with DP, in 24 of 44 (55%) with MX, in 18 of 29 (62%) with AP and 
      10 of 18 (56%) with CZ. AP was comparatively more effective than the other drugs 
      tested. DP was significantly effective on VPCs with organic heart disease as 
      compared to idiopathic VPCs (p less than 0.05), while the other 3 drugs did not 
      have such a tendency. With MX therapy, 10 of the 12 patients with fast VT rate 
      (greater than or equal to 150 beats/min) showed a significant effect while only 4 
      of the 12 patients with non-fast VT rate (greater than or equal to 100 and 150 
      beats/min) had a significant one (p less than 0.05). On the other hand, DP, AP 
      and CZ showed almost the same efficacy at any cycle length of VT. Six patients 
      withdrew from the study, 4 because of digestive troubles with MX therapy, 1 
      because of micturition disturbances with DP and 1 because of skin rash with AP. 
      The average therapeutic plasma levels of DP, MX, AP and CZ were 1.76 +/- 0.54 
      microgram/ml, 1.08 +/- 0.41 microgram/ml, 0.85 +/- 0.43 microgram/ml and 268.2 
      +/- 123.3 ng/ml, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Tanabe, T
AU  - Tanabe T
AD  - Department of Internal Medicine, Tokai University School of Medicine, Isehara, 
      Japan.
FAU - Yoshikawa, H
AU  - Yoshikawa H
FAU - Furuya, H
AU  - Furuya H
FAU - Goto, Y
AU  - Goto Y
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn Circ J
JT  - Japanese circulation journal
JID - 7806868
RN  - 0 (Anti-Arrhythmia Agents)
RN  - 0 (Imidazoles)
RN  - 1U511HHV4Z (Mexiletine)
RN  - 5Y48085P9Q (Aprindine)
RN  - GFO928U8MQ (Disopyramide)
RN  - Z7489237QT (cifenline)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anti-Arrhythmia Agents/*administration & dosage/blood/classification
MH  - Aprindine/administration & dosage/blood
MH  - Arrhythmias, Cardiac/*blood/drug therapy
MH  - Chronic Disease
MH  - Disopyramide/administration & dosage/blood
MH  - Drug Therapy, Combination
MH  - Female
MH  - Heart Ventricles
MH  - Humans
MH  - Imidazoles/administration & dosage/blood
MH  - Male
MH  - Mexiletine/administration & dosage/blood
MH  - Middle Aged
EDAT- 1988/03/01 00:00
MHDA- 1988/03/01 00:01
CRDT- 1988/03/01 00:00
PHST- 1988/03/01 00:00 [pubmed]
PHST- 1988/03/01 00:01 [medline]
PHST- 1988/03/01 00:00 [entrez]
AID - 10.1253/jcj.52.298 [doi]
PST - ppublish
SO  - Jpn Circ J. 1988 Mar;52(3):298-305. doi: 10.1253/jcj.52.298.