PMID- 33738109
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220421
IS  - 2055-1169 (Electronic)
IS  - 2055-1169 (Linking)
VI  - 7
IP  - 1
DP  - 2021 Jan-Jun
TI  - Congenital pituitary cyst resulting in adipsic central diabetes insipidus and 
      secondary hypernatremia in a cat.
PG  - 2055116921990294
LID - 10.1177/2055116921990294 [doi]
LID - 2055116921990294
AB  - CASE SUMMARY: A 9-month-old intact female domestic mediumhair cat presented with 
      a 5-month history of obtundation, lethargy, hypernatremia (181 mmol/l; reference 
      interval [RI] 151-158 mmol/l), hyperchloremia (142 mmol/l; RI 117-126 mmol/l), 
      azotemia (blood urea nitrogen 51 mg/dl; RI 18-33 mg/dl), creatinine 3.0 mg/dl (RI 
      1.1-2.2 mg/dl), hyperphosphatemia (8.3 mg/dl; RI 3.2-6.3 mg/dl) and total 
      hypercalcemia (11.4 mg/dl; RI 9-10.9 mg/dl), with concurrent polyuria with 
      adipsia. Neurologic evaluation revealed proprioceptive deficits, and this finding 
      paired with a history of focal seizure-like activity despite improving sodium 
      concentrations suggested a cerebrothalamic lesion. For this reason, and 
      historical and biochemical findings consistent with adipsic diabetes insipidus 
      (DI), MRI of the brain was performed, which revealed a lesion of the hypophyseal 
      fossa consistent with a pituitary cyst. Given the patient's age and the timeline 
      of clinical signs, a congenital pituitary cyst was strongly suspected. The 
      patient was managed initially with intravenous fluids to correct the 
      hypernatremia, then managed for more than 4 years with topical ocular 
      desmopressin acetate administration and free water administered through a feeding 
      tube. This cat's clinical diagnosis included a congenital pituitary cyst with 
      subsequent central DI and primary adipsia. RELEVANCE AND NOVEL INFORMATION: The 
      clinical presentations of primary adipsia or central DI are both rare in cats. 
      This is the first report to describe these conditions occurring in a cat owing to 
      a congenital pituitary cyst and describes successful long-term management of this 
      condition.
CI  - (c) The Author(s) 2021.
FAU - Evenhuis, Janny
AU  - Evenhuis J
AUID- ORCID: 0000-0003-2953-376X
AD  - William R Pritchard Veterinary Medical Teaching Hospital, University of 
      California Davis, Davis, CA, USA.
FAU - Epstein, Steven E
AU  - Epstein SE
AD  - Department of Surgical and Radiological Sciences, School of Veterinary Medicine, 
      University of California Davis, Davis, CA, USA.
FAU - Della-Maggiore, Ann
AU  - Della-Maggiore A
AD  - Department of Medicine and Epidemiology, School of Veterinary Medicine, 
      University of California Davis, Davis, CA, USA.
AD  - MarQueen Pet Emergency and Specialty Group, Roseville, CA, USA.
FAU - Reagan, Krystle L
AU  - Reagan KL
AD  - Department of Medicine and Epidemiology, School of Veterinary Medicine, 
      University of California Davis, Davis, CA, USA.
LA  - eng
PT  - Case Reports
DEP - 20210227
PL  - England
TA  - JFMS Open Rep
JT  - JFMS open reports
JID - 101672978
PMC - PMC7934035
OTO - NOTNLM
OT  - Feline congenital abnormality
OT  - electrolyte abnormality
OT  - feline endocrinopathy
OT  - pituitary tumor
OT  - polyuria
COIS- Conflict of interest: The authors declared no potential conflicts of interest 
      with respect to the research, authorship, and/or publication of this article.
EDAT- 2021/03/20 06:00
MHDA- 2021/03/20 06:01
PMCR- 2021/02/27
CRDT- 2021/03/19 07:24
PHST- 2021/03/19 07:24 [entrez]
PHST- 2021/03/20 06:00 [pubmed]
PHST- 2021/03/20 06:01 [medline]
PHST- 2021/02/27 00:00 [pmc-release]
AID - 10.1177_2055116921990294 [pii]
AID - 10.1177/2055116921990294 [doi]
PST - epublish
SO  - JFMS Open Rep. 2021 Feb 27;7(1):2055116921990294. doi: 10.1177/2055116921990294. 
      eCollection 2021 Jan-Jun.