PMID- 33739188 OWN - NLM STAT- MEDLINE DCOM- 20210601 LR - 20220320 IS - 1943-4936 (Electronic) IS - 1040-6387 (Print) IS - 1040-6387 (Linking) VI - 33 IP - 3 DP - 2021 May TI - Data standardization implementation and applications within and among diagnostic laboratories: integrating and monitoring enteric coronaviruses. PG - 457-468 LID - 10.1177/10406387211002163 [doi] AB - Every day, thousands of samples from diverse populations of animals are submitted to veterinary diagnostic laboratories (VDLs) for testing. Each VDL has its own laboratory information management system (LIMS), with processes and procedures to capture submission information, perform laboratory tests, define the boundaries of test results (i.e., positive or negative), and report results, in addition to internal business and accounting applications. Enormous quantities of data are accumulated and stored within VDL LIMSs. There is a need for platforms that allow VDLs to exchange and share portions of laboratory data using standardized, reliable, and sustainable information technology processes. Here we report concepts and applications for standardization and aggregation of data from swine submissions to multiple VDLs to detect and monitor porcine enteric coronaviruses by RT-PCR. Oral fluids, feces, and fecal swabs were the specimens submitted most frequently for enteric coronavirus testing. Statistical algorithms were used successfully to scan and monitor the overall and state-specific percentage of positive submissions. Major findings revealed a consistently recurrent seasonal pattern, with the highest percentage of positive submissions detected during December-February for porcine epidemic diarrhea virus, porcine deltacoronavirus, and transmissible gastroenteritis virus (TGEV). After 2014, very few submissions tested positive for TGEV. Monitoring VDL data proactively has the potential to signal and alert stakeholders early of significant changes from expected detection. We demonstrate the importance of, and applications for, data organized and aggregated by using LOINC and SNOMED CTs, as well as the use of customized messaging to allow inter-VDL exchange of information. FAU - Trevisan, Giovani AU - Trevisan G AUID- ORCID: 0000-0002-4980-526X AD - Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA. FAU - Linhares, Leticia C M AU - Linhares LCM AUID- ORCID: 0000-0001-5305-7981 AD - Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA. FAU - Schwartz, Kent J AU - Schwartz KJ AD - Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA. FAU - Burrough, Eric R AU - Burrough ER AUID- ORCID: 0000-0003-4747-9189 AD - Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA. FAU - Magalhaes, Edison de S AU - Magalhaes ES AD - Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA. FAU - Crim, Bret AU - Crim B AD - Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA. FAU - Dubey, Poonam AU - Dubey P AD - Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA. FAU - Main, Rodger G AU - Main RG AD - Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA. FAU - Gauger, Phillip AU - Gauger P AUID- ORCID: 0000-0003-2540-8769 AD - Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA. FAU - Thurn, Mary AU - Thurn M AD - Veterinary Population Medicine, University of Minnesota, Saint Paul, MN. FAU - Lages, Paulo T F AU - Lages PTF AD - Veterinary Population Medicine, University of Minnesota, Saint Paul, MN. FAU - Corzo, Cesar A AU - Corzo CA AD - Veterinary Population Medicine, University of Minnesota, Saint Paul, MN. FAU - Torrison, Jerry AU - Torrison J AD - Veterinary Population Medicine, University of Minnesota, Saint Paul, MN. FAU - Henningson, Jamie AU - Henningson J AD - College of Veterinary Medicine, Kansas State University, Manhattan, KS. FAU - Herrman, Eric AU - Herrman E AD - College of Veterinary Medicine, Kansas State University, Manhattan, KS. FAU - McGaughey, Rob AU - McGaughey R AD - College of Veterinary Medicine, Kansas State University, Manhattan, KS. FAU - Cino, Giselle AU - Cino G AD - College of Veterinary Medicine, Kansas State University, Manhattan, KS. FAU - Greseth, Jon AU - Greseth J AD - Veterinary & Biomedical Sciences Department, South Dakota State University, Brookings, SD. FAU - Clement, Travis AU - Clement T AD - Veterinary & Biomedical Sciences Department, South Dakota State University, Brookings, SD. FAU - Christopher-Hennings, Jane AU - Christopher-Hennings J AD - Veterinary & Biomedical Sciences Department, South Dakota State University, Brookings, SD. FAU - Linhares, Daniel C L AU - Linhares DCL AD - Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA. LA - eng PT - Journal Article DEP - 20210319 PL - United States TA - J Vet Diagn Invest JT - Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc JID - 9011490 SB - IM MH - Animals MH - COVID-19 Testing/veterinary MH - Coronaviridae/*isolation & purification MH - Coronaviridae Infections/diagnosis/*veterinary/virology MH - Disease Outbreaks MH - Feces/virology MH - Laboratories/*standards MH - Reference Standards MH - Seasons MH - Swine MH - Swine Diseases/diagnosis/*virology PMC - PMC8120076 OTO - NOTNLM OT - PDCoV OT - PEDV OT - TGEV OT - data integration OT - data standardization OT - enteric coronavirus OT - monitoring OT - veterinary diagnostic laboratories COIS- Declaration of conflicting interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2021/03/20 06:00 MHDA- 2021/06/02 06:00 PMCR- 2022/03/19 CRDT- 2021/03/19 12:15 PHST- 2021/03/20 06:00 [pubmed] PHST- 2021/06/02 06:00 [medline] PHST- 2021/03/19 12:15 [entrez] PHST- 2022/03/19 00:00 [pmc-release] AID - 10.1177_10406387211002163 [pii] AID - 10.1177/10406387211002163 [doi] PST - ppublish SO - J Vet Diagn Invest. 2021 May;33(3):457-468. doi: 10.1177/10406387211002163. Epub 2021 Mar 19.