PMID- 33740172
OWN - NLM
STAT- MEDLINE
DCOM- 20220630
LR  - 20220630
IS  - 1573-6830 (Electronic)
IS  - 0272-4340 (Linking)
VI  - 42
IP  - 6
DP  - 2022 Aug
TI  - Targeting Several Biologically Reported Targets of Glioblastoma Multiforme by 
      Assaying 2D and 3D Cultured Cells.
PG  - 1909-1920
LID - 10.1007/s10571-021-01072-9 [doi]
AB  - Glioblastoma multiforme (GBM) is account for 70% of all primary malignancies of 
      the central nervous system. The median survival of human patients after treatment 
      is around 15 months. There are several biological targets which have been 
      reported that can be pursued using ligands with varied structures to treat this 
      disease. In our group, we have developed several ligands that target a wide range 
      of proteins involved in anticancer effects, such as histone deacetylase (HDACs), 
      G protein-coupled estrogen receptor 1 (GPER), estrogen receptor-beta (ERbeta) and 
      NADPH oxidase (NOX), that were screened on bidimensional (2D) and tridimensional 
      (3D) GBM stem cells like (GSC). Our results show that some HDAC inhibitors show 
      antiproliferative properties at 21-32 microM. These results suggest that in this 3D 
      culture, HDACs could be the most relevant targets that are modulated to induce 
      the antiproliferative effects that require in the future further experimental 
      studies.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Sixto-Lopez, Yudibeth
AU  - Sixto-Lopez Y
AUID- ORCID: 0000-0001-8903-3834
AD  - Laboratorio de Diseno y Desarrollo de Nuevos Farmacos y Productos 
      Biotecnologicos, Seccion de Estudios de Posgrado e Investigacion, Escuela 
      Superior de Medicina, Instituto Politecnico Nacional, Plan de San Luis y Diaz 
      Miron, 11340, Mexico City, Mexico.
FAU - Marhuenda, Emilie
AU  - Marhuenda E
AUID- ORCID: 0000-0003-2357-9505
AD  - Institut des Neurosciences de Montpellier, INM, U-1051, Univ. Montpellier, CHU de 
      Montpellier, ENSCM, INSERM, Montpellier, France.
FAU - Garcia-Vazquez, Juan Benjamin
AU  - Garcia-Vazquez JB
AUID- ORCID: 0000-0003-1930-5288
AD  - Laboratorio de Diseno y Desarrollo de Nuevos Farmacos y Productos 
      Biotecnologicos, Seccion de Estudios de Posgrado e Investigacion, Escuela 
      Superior de Medicina, Instituto Politecnico Nacional, Plan de San Luis y Diaz 
      Miron, 11340, Mexico City, Mexico. benjagv_5202@hotmail.com.
FAU - Fragoso-Vazquez, Manuel Jonathan
AU  - Fragoso-Vazquez MJ
AUID- ORCID: 0000-0002-4730-8921
AD  - Departamento de Quimica Organica, Escuela Nacional de Ciencias Biologicas, 
      Instituto Politecnico Nacional Prolongacion de Carpio y Plan de Ayala S/N. Col. 
      Casco de Santo Tomas, 11340, Ciudad de Mexico, Mexico.
FAU - Rosales-Hernandez, Martha Cecilia
AU  - Rosales-Hernandez MC
AUID- ORCID: 0000-0003-0012-580X
AD  - Laboratorio de Biofisica y Biocatalisis, Escuela Superior de Medicina, Instituto 
      Politecnico Nacional, Plan de San Luis y Diaz Miron s/n, 11340, Ciudad de Mexico, 
      Mexico.
FAU - Zacarias-Lara, Oscar
AU  - Zacarias-Lara O
AUID- ORCID: 0000-0001-6950-9997
AD  - Laboratorio de Diseno y Desarrollo de Nuevos Farmacos y Productos 
      Biotecnologicos, Seccion de Estudios de Posgrado e Investigacion, Escuela 
      Superior de Medicina, Instituto Politecnico Nacional, Plan de San Luis y Diaz 
      Miron, 11340, Mexico City, Mexico.
FAU - Mendez-Luna, David
AU  - Mendez-Luna D
AUID- ORCID: 0000-0002-2488-7916
AD  - Laboratorio de Diseno y Desarrollo de Nuevos Farmacos y Productos 
      Biotecnologicos, Seccion de Estudios de Posgrado e Investigacion, Escuela 
      Superior de Medicina, Instituto Politecnico Nacional, Plan de San Luis y Diaz 
      Miron, 11340, Mexico City, Mexico.
FAU - Gomez-Vidal, Jose Antonio
AU  - Gomez-Vidal JA
AUID- ORCID: 0000-0003-0937-698X
AD  - Facultad de Farmacia, Departamento de Quimica Farmaceutica y Organica, 
      Universidad de Granada, Campus de Cartuja, 18071, Granada, Spain.
FAU - Cornu, David
AU  - Cornu D
AUID- ORCID: 0000-0002-5205-3038
AD  - Institut Europeen des Membranes, IEM, UMR-5635, Univ. Montpellier, ENSCM, CNRS, 
      Montpellier, France.
FAU - Norbert, Bakalara
AU  - Norbert B
AUID- ORCID: 0000-0001-7412-5891
AD  - Institut des Neurosciences de Montpellier, INM, U-1051, Univ. Montpellier, CHU de 
      Montpellier, ENSCM, INSERM, Montpellier, France.
FAU - Correa-Basurto, Jose
AU  - Correa-Basurto J
AUID- ORCID: 0000-0002-4973-5265
AD  - Laboratorio de Diseno y Desarrollo de Nuevos Farmacos y Productos 
      Biotecnologicos, Seccion de Estudios de Posgrado e Investigacion, Escuela 
      Superior de Medicina, Instituto Politecnico Nacional, Plan de San Luis y Diaz 
      Miron, 11340, Mexico City, Mexico. corrjose@gmail.com.
LA  - eng
GR  - 254600/CONACYT/
PT  - Journal Article
DEP - 20210319
PL  - United States
TA  - Cell Mol Neurobiol
JT  - Cellular and molecular neurobiology
JID - 8200709
RN  - 0 (Histone Deacetylase Inhibitors)
RN  - 0 (Ligands)
RN  - EC 3.5.1.98 (Histone Deacetylases)
SB  - IM
MH  - *Brain Neoplasms/drug therapy/pathology
MH  - Cell Line, Tumor
MH  - Cell Proliferation
MH  - *Glioblastoma/pathology
MH  - Histone Deacetylase Inhibitors/pharmacology
MH  - Histone Deacetylases
MH  - Humans
MH  - Ligands
OTO - NOTNLM
OT  - 3D cell culture
OT  - ER
OT  - GPER
OT  - Glioblastoma multiforme
OT  - HDAC
OT  - NOX
EDAT- 2021/03/20 06:00
MHDA- 2022/07/01 06:00
CRDT- 2021/03/19 17:30
PHST- 2020/08/05 00:00 [received]
PHST- 2021/03/01 00:00 [accepted]
PHST- 2021/03/20 06:00 [pubmed]
PHST- 2022/07/01 06:00 [medline]
PHST- 2021/03/19 17:30 [entrez]
AID - 10.1007/s10571-021-01072-9 [pii]
AID - 10.1007/s10571-021-01072-9 [doi]
PST - ppublish
SO  - Cell Mol Neurobiol. 2022 Aug;42(6):1909-1920. doi: 10.1007/s10571-021-01072-9. 
      Epub 2021 Mar 19.