PMID- 33740216
OWN - NLM
STAT- MEDLINE
DCOM- 20210521
LR  - 20210608
IS  - 1865-8652 (Electronic)
IS  - 0741-238X (Linking)
VI  - 38
IP  - 5
DP  - 2021 May
TI  - A Retrospective Cohort Study of Sublingual Immunotherapy with Standardized 
      Dermatophagoides farinae Drops for Allergic Rhinitis.
PG  - 2315-2322
LID - 10.1007/s12325-021-01686-x [doi]
AB  - INTRODUCTION: To evaluate the efficacy and safety of sublingual immunotherapy 
      (SLIT) with standardized Dermatophagoides farinae (Df) drops in monosensitized 
      and polysensitized patients with allergic rhinitis (AR) and to analyze the 
      adverse events (AEs). METHODS: A retrospective analysis was performed using data 
      for 68 patients with AR who received SLIT. The patients were divided into a 
      monosensitized group (36 cases) and a polysensitized group (32 cases) based on 
      serum-specific IgE test results. In the two groups of patients, total nasal 
      symptoms score (TNSS), total medication score (TMS), visual analog scale (VAS) 
      score, and AEs before treatment and at 1, 3, 6, and 12 months of treatment were 
      evaluated. RESULTS: Compared with that before treatment, the TNSS, TMS, and VAS 
      score in the monosensitized and polysensitized groups all decreased significantly 
      at 3, 6, and 12 months of SLIT (all P < 0.05). There were no significant 
      differences in treatment efficacy indicators between the two groups at all 
      treatment time points (all P > 0.05). In terms of safety, compared with 1 month 
      after initiating SLIT, the incidence of AEs in the monosensitized and 
      polysensitized groups at 6 and 12 months of treatment significantly decreased 
      (all P < 0.05). There was a statistically significant decrease in the incidence 
      of AEs in both groups at 6 months compared with 3 months of treatment 
      (chi(2) = 1.92 and 5.85, respectively, all P < 0.05). The difference in incidence 
      of AEs between the monosensitized and polysensitized groups was not statistically 
      significant at any treatment time point (all P > 0.05). AEs in all patients were 
      local mild reactions; no serious AEs were found. CONCLUSION: SLIT with 
      standardized Df drops has similar efficacy and safety for monosensitized and 
      polysensitized patients with AR. AEs mostly occurred during the first 3 months of 
      SLIT in both the monosensitized and polysensitized groups, and the incidence of 
      AEs gradually decreased as the course of treatment extended.
FAU - Ma, Xingkai
AU  - Ma X
AD  - Department of Otolaryngology, Zhangjiagang Hospital Affiliated to Soochow 
      University, Suzhou, China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - Department of Otolaryngology, Zhangjiagang Hospital Affiliated to Soochow 
      University, Suzhou, China.
FAU - Gu, Xiaodan
AU  - Gu X
AD  - Department of Otolaryngology, Fifth People Hospital of Zhangjiagang City, Suzhou, 
      China.
FAU - Wu, Geping
AU  - Wu G
AUID- ORCID: 0000-0002-7194-0716
AD  - Department of Otolaryngology, Zhangjiagang Hospital Affiliated to Soochow 
      University, Suzhou, China. Gordon-wu@qq.com.
AD  - Institute of Translational Medicine, Zhangjiagang Hospital Affiliated to Soochow 
      University, Suzhou, China. Gordon-wu@qq.com.
FAU - Liu, Jianyong
AU  - Liu J
AD  - Department of Otolaryngology, Zhangjiagang Hospital Affiliated to Soochow 
      University, Suzhou, China.
FAU - Lu, Jianbin
AU  - Lu J
AD  - Department of Otolaryngology, Zhangjiagang Hospital Affiliated to Soochow 
      University, Suzhou, China.
FAU - Yang, Huijun
AU  - Yang H
AD  - Department of Otolaryngology, Zhangjiagang Hospital Affiliated to Soochow 
      University, Suzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210319
PL  - United States
TA  - Adv Ther
JT  - Advances in therapy
JID - 8611864
RN  - 0 (Antigens, Dermatophagoides)
MH  - Animals
MH  - Antigens, Dermatophagoides
MH  - Dermatophagoides farinae
MH  - Humans
MH  - Retrospective Studies
MH  - *Rhinitis, Allergic/therapy
MH  - *Sublingual Immunotherapy
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Adverse events
OT  - Allergic rhinitis
OT  - Standardized Dermatophagoides farinae drops
OT  - Sublingual immunotherapy
EDAT- 2021/03/20 06:00
MHDA- 2021/05/22 06:00
CRDT- 2021/03/19 17:32
PHST- 2021/01/22 00:00 [received]
PHST- 2021/02/24 00:00 [accepted]
PHST- 2021/03/20 06:00 [pubmed]
PHST- 2021/05/22 06:00 [medline]
PHST- 2021/03/19 17:32 [entrez]
AID - 10.1007/s12325-021-01686-x [pii]
AID - 10.1007/s12325-021-01686-x [doi]
PST - ppublish
SO  - Adv Ther. 2021 May;38(5):2315-2322. doi: 10.1007/s12325-021-01686-x. Epub 2021 
      Mar 19.