PMID- 33740478
OWN - NLM
STAT- MEDLINE
DCOM- 20210629
LR  - 20221207
IS  - 1872-6976 (Electronic)
IS  - 0167-4943 (Linking)
VI  - 95
DP  - 2021 Jul-Aug
TI  - Factors associated with relative muscle strength in patients with type 2 diabetes 
      mellitus.
PG  - 104384
LID - S0167-4943(21)00047-9 [pii]
LID - 10.1016/j.archger.2021.104384 [doi]
AB  - OBJECTIVES: Some patients with type 2 diabetes mellitus (T2DM) experience 
      decreased mobility associated with lower relative muscle strength (normalized 
      with muscle mass). This study aimed to identify factors predicting relative 
      muscle strength of patients with T2DM assessed at regular clinical visits. 
      METHODS: A total of 144 T2DM patients underwent fasting blood drawing 
      (determining white blood cell count [WBC], diabetic kidney disease [DKD], and 
      glycated hemoglobin [HbA1c]) and the assessment of body composition, diabetic 
      peripheral neuropathy (DPN), activity level, and muscle strength (grip, knee 
      extensor, and ankle plantar flexor strength). One-way ANOVA and multiple 
      regression models were used to identify factors associated with the relative 
      muscle strength. RESULTS: Our data showed that age, diabetes duration, fat 
      percentage, WBC, DPN, and DKD were negatively associated with the relative muscle 
      strength. Specifically, a greater WBC was associated with lower relative muscle 
      strength of both distal and proximal muscle groups of extremities after the 
      adjustment of other associated factors. DPN was associated with lower relative 
      strength of the distal muscle groups of extremities. CONCLUSIONS: WBC may be used 
      as a marker of inflammation, and greater count, even within the normal range, is 
      negatively associated with the relative muscle strength in patients with T2DM.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Chen, Chiao-Nan
AU  - Chen CN
AD  - Department of Physical Therapy and Assistive Technology, School of Biomedical 
      Science and Engineering, National Yang Ming Chiao Tung University, Taipei, 
      Taiwan.
FAU - Chen, Ting-Chung
AU  - Chen TC
AD  - Department of Physical Therapy and Assistive Technology, School of Biomedical 
      Science and Engineering, National Yang Ming Chiao Tung University, Taipei, 
      Taiwan.
FAU - Tsai, Shiow-Chwen
AU  - Tsai SC
AD  - Institute of Sports Sciences, University of Taipei, Taipei, Taiwan.
FAU - Hwu, Chii-Min
AU  - Hwu CM
AD  - Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans 
      General Hospital, Taipei, Taiwan; Faculty of Medicine, National Yang Ming Chiao 
      Tung University School of Medicine, Taipei, Taiwan. Electronic address: 
      chhwu@vghtpe.gov.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210226
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - *Diabetes Mellitus, Type 2
MH  - *Diabetic Neuropathies
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Knee
MH  - Muscle Strength
OTO - NOTNLM
OT  - Inflammation
OT  - Muscle strength
OT  - T2DM
EDAT- 2021/03/20 06:00
MHDA- 2021/06/30 06:00
CRDT- 2021/03/19 20:10
PHST- 2020/11/12 00:00 [received]
PHST- 2021/02/22 00:00 [revised]
PHST- 2021/02/24 00:00 [accepted]
PHST- 2021/03/20 06:00 [pubmed]
PHST- 2021/06/30 06:00 [medline]
PHST- 2021/03/19 20:10 [entrez]
AID - S0167-4943(21)00047-9 [pii]
AID - 10.1016/j.archger.2021.104384 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 2021 Jul-Aug;95:104384. doi: 
      10.1016/j.archger.2021.104384. Epub 2021 Feb 26.