PMID- 33741286
OWN - NLM
STAT- MEDLINE
DCOM- 20211005
LR  - 20211005
IS  - 2212-4411 (Electronic)
VI  - 132
IP  - 3
DP  - 2021 Sep
TI  - Salivary duct carcinoma and small cell carcinoma ex-pleomorphic adenoma: A 
      heretofore undescribed entity and the naming conundrum: MiNEN, combined, 
      collision, or composite tumor?
PG  - e92-e96
LID - S2212-4403(21)00069-9 [pii]
LID - 10.1016/j.oooo.2021.01.022 [doi]
AB  - Carcinoma with dual neuroendocrine and non-neuroendocrine components are 
      recognized albeit a rare occurrence among the head and neck tumours. Owing to a 
      disjointed pathology taxonomy and a lack of defining criteria, these tumors have 
      remained underrecognized and poorly understood by pathologists and oncologists. 
      Herein, we present a heretofore unreported case of a mixed neuroendocrine 
      non-neuroendocrine carcinoma occurring as a carcinoma ex-pleomorphic adenoma 
      (CXPA) in the soft palate of a 32-year-old man. Histologic examination revealed 2 
      distinctive malignancies comprising salivary duct carcinoma (SDC) and small cell 
      carcinoma (SmCC) arising in a background of a benign pleomorphic adenoma. On 
      immunohistochemistry, the SDC cells were cytokeratin 7 positive, androgen 
      receptor positive, GATA-3 (GATA binding protein 3) positive, and gross cystic 
      disease fluid protein (GCDFP-15) positive and the SmCC cells were synaptophysin 
      positive and chromogranin positive, confirming the presence of 2 different 
      histologic malignancies. We report this case not only for its exceptional rarity 
      but also to discuss the lacunae that exist in the current classification systems 
      that might facilitate an erroneous categorization of these rare tumors. 
      Standardization of nomenclature and defining criteria is imperative to ensure 
      accurate diagnosis, optimal management, and a better understanding of the biology 
      of these enigmatic tumors.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Bal, Munita Meenu
AU  - Bal MM
AD  - Department of Pathology, Tata Memorial Centre, Homi Bhabha National Institute, 
      Mumbai, Maharashtra, India. Electronic address: munitamenon@gmail.com.
FAU - Hubale, Bharati
AU  - Hubale B
AD  - Department of Pathology, Tata Memorial Centre, Homi Bhabha National Institute, 
      Mumbai, Maharashtra, India.
FAU - Janu, Amit
AU  - Janu A
AD  - Department of Radiodiagnosis, Tata Memorial Centre, Homi Bhabha National 
      Institute, Mumbai, Maharashtra, India.
FAU - Patil, Asawari
AU  - Patil A
AD  - Department of Pathology, Tata Memorial Centre, Homi Bhabha National Institute, 
      Mumbai, Maharashtra, India.
LA  - eng
PT  - Case Reports
DEP - 20210128
PL  - United States
TA  - Oral Surg Oral Med Oral Pathol Oral Radiol
JT  - Oral surgery, oral medicine, oral pathology and oral radiology
JID - 101576782
SB  - IM
MH  - *Adenoma, Pleomorphic
MH  - Adult
MH  - *Carcinoma
MH  - *Carcinoma, Small Cell
MH  - Humans
MH  - Male
MH  - Salivary Ducts
MH  - *Salivary Gland Neoplasms/diagnostic imaging
EDAT- 2021/03/21 06:00
MHDA- 2021/10/06 06:00
CRDT- 2021/03/20 05:55
PHST- 2020/12/06 00:00 [received]
PHST- 2021/01/14 00:00 [revised]
PHST- 2021/01/24 00:00 [accepted]
PHST- 2021/03/21 06:00 [pubmed]
PHST- 2021/10/06 06:00 [medline]
PHST- 2021/03/20 05:55 [entrez]
AID - S2212-4403(21)00069-9 [pii]
AID - 10.1016/j.oooo.2021.01.022 [doi]
PST - ppublish
SO  - Oral Surg Oral Med Oral Pathol Oral Radiol. 2021 Sep;132(3):e92-e96. doi: 
      10.1016/j.oooo.2021.01.022. Epub 2021 Jan 28.