PMID- 33742477 OWN - NLM STAT- MEDLINE DCOM- 20210809 LR - 20210809 IS - 1398-9995 (Electronic) IS - 0105-4538 (Linking) VI - 76 IP - 8 DP - 2021 Aug TI - Associations between specific IgE sensitization to 26 respiratory allergen molecules and HLA class II alleles in the EGEA cohort. PG - 2575-2586 LID - 10.1111/all.14820 [doi] AB - BACKGROUND: Allergy, the most frequent immune disorder affecting 30% of the world's population, is the consequence of immunoglobin E (IgE) sensitization to allergens. Among the genetic factors suspected to be involved in allergy, the HLA class-II genomic region is a strong candidate. OBJECTIVE: To assess the association between HLA class-II alleles and specific IgE (sIgE) sensitization to a large number of respiratory allergen molecules. METHODS: The analysis relied on 927 participants of the EGEA cohort, including 497 asthmatics. The study focuses on 26 aeroallergens recognized by sIgE in at least 5% of the study population (determined with the MEDALL chip with sIgE >/= 0.3 ISU) and 23 imputed HLA class-II alleles. For each sIgE sensitization and HLA class-II allele, we fitted a logistic regression model accounting for familial dependence and adjusted for gender, age, and genetic principal components. p-values were corrected for multiple comparisons (False Discovery Rate). RESULTS: Most of the 19 statistically significant associations observed regard pollen allergens (mugwort Art v 1, olive tree Ole e 1, timothy grass Phl p 2, Phl p 5 and plantain Pla l 1), three were mold allergen (Alternaria Alt a 1), and a single one regards house dust mite allergen (Der p 7). No association was observed with pet allergens. The strongest associations were found with mugwort Art v 1 (OR = 5.42 (95%CI, 3.30; 8.88), 4.14 (2.65; 6.47), 3.16 (1.88; 5.31) with DQB1*05:01, DQA1*01:01 and DRB1*01:01, respectively). CONCLUSION: Our results support the important role of HLA class-II alleles as immune response genes predisposing their carriers for sensitization to various major pollen allergens. CI - (c) 2021 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd. FAU - Gheerbrant, Hubert AU - Gheerbrant H AUID- ORCID: 0000-0003-2375-3059 AD - Service Hospitalier Universitaire Pneumologie Physiologie, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France. AD - Inserm, CNRS, IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, University Grenoble Alpes, Grenoble, France. FAU - Guillien, Alicia AU - Guillien A AD - Inserm, CNRS, IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, University Grenoble Alpes, Grenoble, France. FAU - Vernet, Raphael AU - Vernet R AD - UMRS 1124, INSERM, Group of Genomic Epidemiology of Multifactorial Diseases, Universite de Paris, Paris, France. FAU - Lupinek, Christian AU - Lupinek C AD - Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. FAU - Pison, Christophe AU - Pison C AD - Service Hospitalier Universitaire Pneumologie Physiologie, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France. AD - Inserm 1055, Laboratoire de Bioenergetique Fondamentale et Appliquee, Grenoble, France. FAU - Pin, Isabelle AU - Pin I AD - Inserm, CNRS, IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, University Grenoble Alpes, Grenoble, France. AD - Department of Pediatrics, Grenoble-Alpes University Hospital, Grenoble, France. FAU - Demenais, Florence AU - Demenais F AD - UMRS 1124, INSERM, Group of Genomic Epidemiology of Multifactorial Diseases, Universite de Paris, Paris, France. FAU - Nadif, Rachel AU - Nadif R AD - Universite Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Equipe d'Epidemiologie respiratoire integrative, CESP, Villejuif, France. FAU - Bousquet, Jean AU - Bousquet J AD - Arnaud de Villeneuve University Hospital and Inserm, Montpellier, France. FAU - Pickl, Winfried F AU - Pickl WF AD - Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. FAU - Valenta, Rudolf AU - Valenta R AD - Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. AD - NRC Institute of Immunology FMBA of Russia, Moscow, Russia. AD - Laboratory for Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, Moscow, Russia. AD - Karl Landsteiner University of Health Sciences, Krems, Austria. FAU - Bouzigon, Emmanuelle AU - Bouzigon E AD - UMRS 1124, INSERM, Group of Genomic Epidemiology of Multifactorial Diseases, Universite de Paris, Paris, France. FAU - Siroux, Valerie AU - Siroux V AUID- ORCID: 0000-0001-7329-7237 AD - Inserm, CNRS, IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, University Grenoble Alpes, Grenoble, France. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210407 PL - Denmark TA - Allergy JT - Allergy JID - 7804028 RN - 0 (Allergens) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Alleles MH - *Allergens MH - Humans MH - *Hypersensitivity/genetics MH - Immunoglobulin E MH - Phleum OTO - NOTNLM OT - HLA class-II genes OT - MeDALL allergen-chip OT - genetic epidemiology OT - respiratory allergen OT - specific IgE EDAT- 2021/03/21 06:00 MHDA- 2021/08/10 06:00 CRDT- 2021/03/20 06:54 PHST- 2021/01/27 00:00 [revised] PHST- 2020/10/08 00:00 [received] PHST- 2021/02/09 00:00 [accepted] PHST- 2021/03/21 06:00 [pubmed] PHST- 2021/08/10 06:00 [medline] PHST- 2021/03/20 06:54 [entrez] AID - 10.1111/all.14820 [doi] PST - ppublish SO - Allergy. 2021 Aug;76(8):2575-2586. doi: 10.1111/all.14820. Epub 2021 Apr 7.