PMID- 33742532
OWN - NLM
STAT- MEDLINE
DCOM- 20220128
LR  - 20220128
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 100
IP  - 1
DP  - 2022 Feb
TI  - Parapapillary deep-layer microvasculature dropout is only found near the retinal 
      nerve fibre layer defect location in open-angle glaucoma.
PG  - e174-e180
LID - 10.1111/aos.14856 [doi]
AB  - PURPOSE: We aimed to investigate the topographic correspondence between 
      deep-layer microvasculature dropout (MvD) and retinal nerve fibre layer (RNFL) 
      defects in eyes with open-angle glaucoma (OAG) using spectral-domain optical 
      coherence tomography (SD-OCT) and optical coherence tomography angiography 
      (OCT-A). METHODS: Microvasculature dropout width and location were determined 
      using OCT-A, RNFL thickness, RNFL defect width and location were revealed using 
      SD-OCT. The association between MvD and RNFL widths and that between the location 
      of the MvD and RNFL defects were investigated. In addition, patients with OAG 
      were divided into two groups: the RNFL defect in one hemiretina (RNFLD-HR) group 
      (n = 24 eyes) and the RNFL defects in both hemiretinas (RNFLD-BR) group (n = 25 
      eyes). The presence, width and location of MvDs were compared between the two 
      groups. RESULTS: Forty-nine eyes were included. In 24 RNFLD-HR eyes, all MvDs 
      were found in the inferior area, corresponding with the location of the RNFL 
      defect. Meanwhile, in 25 RNFLD-BR eyes, 18 MvDs (72%) were found in the inferior 
      hemiretina, two (8%) were found in the superior hemiretina, and five (20%) were 
      found in both hemiretinas. In RNFLD-BR eyes, the average RNFL thickness was 
      thinner in a location with MvD than a location without MvD. CONCLUSION: 
      Considering that MvD is only observed at the location of the RNFL defect in 
      RNFLD-HR eyes and is usually found in the location of more severe RNFL defects in 
      RNFLD-BR eyes, MvD seems to be a sign that accompanies glaucomatous damage in OAG 
      eyes.
CI  - (c) 2021 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & 
      Sons Ltd.
FAU - Son, Ki Young
AU  - Son KY
AD  - Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, Seoul, Korea.
FAU - Han, Jong Chul
AU  - Han JC
AUID- ORCID: 0000-0001-9242-1168
AD  - Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, Seoul, Korea.
FAU - Kee, Changwon
AU  - Kee C
AUID- ORCID: 0000-0002-7419-0316
AD  - Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, Seoul, Korea.
LA  - eng
GR  - 2017R1D1A1B03034834/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20210319
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fluorescein Angiography/*methods
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - Glaucoma, Open-Angle/*diagnosis/physiopathology
MH  - Humans
MH  - Male
MH  - Microvessels/*diagnostic imaging
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Optic Disk/*blood supply/diagnostic imaging
MH  - Retinal Ganglion Cells/*pathology
MH  - Retinal Vessels/*diagnostic imaging
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - Young Adult
OTO - NOTNLM
OT  - microvasculature dropout
OT  - open-angle glaucoma
OT  - retinal nerve fibre layer defect
EDAT- 2021/03/21 06:00
MHDA- 2022/01/29 06:00
CRDT- 2021/03/20 06:58
PHST- 2020/06/20 00:00 [received]
PHST- 2021/03/02 00:00 [accepted]
PHST- 2021/03/21 06:00 [pubmed]
PHST- 2022/01/29 06:00 [medline]
PHST- 2021/03/20 06:58 [entrez]
AID - 10.1111/aos.14856 [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2022 Feb;100(1):e174-e180. doi: 10.1111/aos.14856. Epub 2021 Mar 
      19.