PMID- 33743764
OWN - NLM
STAT- MEDLINE
DCOM- 20211109
LR  - 20211109
IS  - 2045-8118 (Electronic)
IS  - 2045-8118 (Linking)
VI  - 18
IP  - 1
DP  - 2021 Mar 20
TI  - Neural crest cell-derived pericytes act as pro-angiogenic cells in human 
      neocortex development and gliomas.
PG  - 14
LID - 10.1186/s12987-021-00242-7 [doi]
LID - 14
AB  - Central nervous system diseases involving the parenchymal microvessels are 
      frequently associated with a 'microvasculopathy', which includes different levels 
      of neurovascular unit (NVU) dysfunction, including blood-brain barrier 
      alterations. To contribute to the understanding of NVU responses to pathological 
      noxae, we have focused on one of its cellular components, the microvascular 
      pericytes, highlighting unique features of brain pericytes with the aid of the 
      analyses carried out during vascularization of human developing neocortex and in 
      human gliomas. Thanks to their position, centred within the endothelial/glial 
      partition of the vessel basal lamina and therefore inserted between endothelial 
      cells and the perivascular and vessel-associated components (astrocytes, 
      oligodendrocyte precursor cells (OPCs)/NG2-glia, microglia, macrophages, nerve 
      terminals), pericytes fulfil a central role within the microvessel NVU. Indeed, 
      at this critical site, pericytes have a number of direct and extracellular matrix 
      molecule- and soluble factor-mediated functions, displaying marked phenotypical 
      and functional heterogeneity and carrying out multitasking services. This 
      pericytes heterogeneity is primarily linked to their position in specific tissue 
      and organ microenvironments and, most importantly, to their ontogeny. During 
      ontogenesis, pericyte subtypes belong to two main embryonic germ layers, mesoderm 
      and (neuro)ectoderm, and are therefore expected to be found in organs 
      ontogenetically different, nonetheless, pericytes of different origin may 
      converge and colonize neighbouring areas of the same organ/apparatus. Here, we 
      provide a brief overview of the unusual roles played by forebrain pericytes in 
      the processes of angiogenesis and barriergenesis by virtue of their origin from 
      midbrain neural crest stem cells. A better knowledge of the ontogenetic 
      subpopulations may support the understanding of specific interactions and 
      mechanisms involved in pericyte function/dysfunction, including normal and 
      pathological angiogenesis, thereby offering an alternative perspective on cell 
      subtype-specific therapeutic approaches.
FAU - Girolamo, Francesco
AU  - Girolamo F
AUID- ORCID: 0000-0001-8706-3386
AD  - Department of Basic Medical Sciences, Neuroscience and Sensory Organs, Human 
      Anatomy and Histology Unit, University of Bari School of Medicine, Bari, Italy. 
      fgirolamo13@gmail.com.
FAU - de Trizio, Ignazio
AU  - de Trizio I
AD  - Department of Basic Medical Sciences, Neuroscience and Sensory Organs, Human 
      Anatomy and Histology Unit, University of Bari School of Medicine, Bari, Italy.
AD  - Intensive Care Unit, Department of Intensive Care, Regional Hospital of Lugano, 
      Ente Ospedaliero Cantonale, Lugano, Switzerland.
FAU - Errede, Mariella
AU  - Errede M
AD  - Department of Basic Medical Sciences, Neuroscience and Sensory Organs, Human 
      Anatomy and Histology Unit, University of Bari School of Medicine, Bari, Italy.
FAU - Longo, Giovanna
AU  - Longo G
AD  - Department of Basic Medical Sciences, Neuroscience and Sensory Organs, Molecular 
      Biology Unit, University of Bari School of Medicine, Bari, Italy.
FAU - d'Amati, Antonio
AU  - d'Amati A
AD  - Department of Basic Medical Sciences, Neuroscience and Sensory Organs, Human 
      Anatomy and Histology Unit, University of Bari School of Medicine, Bari, Italy.
AD  - Department of Emergency and Organ Transplantation, Pathology Section, University 
      of Bari School of Medicine, Bari, Italy.
FAU - Virgintino, Daniela
AU  - Virgintino D
AD  - Department of Basic Medical Sciences, Neuroscience and Sensory Organs, Human 
      Anatomy and Histology Unit, University of Bari School of Medicine, Bari, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210320
PL  - England
TA  - Fluids Barriers CNS
JT  - Fluids and barriers of the CNS
JID - 101553157
SB  - IM
MH  - Glioma/*physiopathology
MH  - Humans
MH  - Neocortex/*blood supply/*growth & development
MH  - Neovascularization, Pathologic/*physiopathology
MH  - Neovascularization, Physiologic/*physiology
MH  - Neural Crest/*cytology
MH  - Pericytes/*physiology
PMC - PMC7980348
OTO - NOTNLM
OT  - Angiogenesis
OT  - Blood-brain barrier
OT  - Human brain development
OT  - Human gliomas
OT  - Microvessels
OT  - Neural crest cells
OT  - Pericytes
OT  - Prosencephalon
OT  - Tunnelling nanotubes
COIS- All the authors declare that they have no competing interests.
EDAT- 2021/03/22 06:00
MHDA- 2021/11/10 06:00
PMCR- 2021/03/20
CRDT- 2021/03/21 20:34
PHST- 2020/09/28 00:00 [received]
PHST- 2021/02/13 00:00 [accepted]
PHST- 2021/03/21 20:34 [entrez]
PHST- 2021/03/22 06:00 [pubmed]
PHST- 2021/11/10 06:00 [medline]
PHST- 2021/03/20 00:00 [pmc-release]
AID - 10.1186/s12987-021-00242-7 [pii]
AID - 242 [pii]
AID - 10.1186/s12987-021-00242-7 [doi]
PST - epublish
SO  - Fluids Barriers CNS. 2021 Mar 20;18(1):14. doi: 10.1186/s12987-021-00242-7.