PMID- 33744141
OWN - NLM
STAT- MEDLINE
DCOM- 20211008
LR  - 20211008
IS  - 1876-7591 (Electronic)
IS  - 1876-7591 (Linking)
VI  - 14
IP  - 7
DP  - 2021 Jul
TI  - Left Ventricular Longitudinal Strain in Characterization and Outcome Assessment 
      of Mixed Aortic Valve Disease Phenotypes.
PG  - 1324-1334
LID - S1936-878X(21)00088-7 [pii]
LID - 10.1016/j.jcmg.2021.01.020 [doi]
AB  - OBJECTIVES: The aims of this study were to characterize the interplay between 
      mixed aortic valve disease (MAVD) phenotypes (defined by concomitant severities 
      of aortic stenosis and aortic regurgitation) and left ventricular global 
      longitudinal strain (LV-GLS), and to assess the prognostic utility of LV-GLS in 
      MAVD. BACKGROUND: Little is known about the way LV-GLS separates MAVD phenotypes 
      and if it is associated with their outcomes. METHODS: This observational cohort 
      study evaluated 783 consecutive adult patients with left ventricular ejection 
      fraction >/=50% and MAVD, which was defined as coexisting with at least moderate 
      aortic stenosis and at least moderate aortic regurgitation. We measured the 
      conventional echocardiographic variables and average LV-GLS from apical long, 2- 
      and 4-chamber views. The primary endpoint was all-cause mortality. RESULTS: Mean 
      age of patients was 69 +/- 15 years, and 58% were male. Mean LV-GLS was -14.7 +/- 
      2.9%. In total, 458 patients (59%) underwent aortic valve replacement at a median 
      period of 50 days (25th to 75th percentile range: 6 to 560 days). During a median 
      follow-up period of 5.6 years (25th to 75th percentile range: 1.8 to 9.4 years), 
      391 patients (50%) died. When stratified patients into tertiles according to 
      LV-GLS values, patients with worse LV-GLS had worse outcomes (p < 0.001). LV-GLS 
      was independently associated with mortality (hazard ratio: 1.09; 95% confidential 
      intervals: 1.04 to 1.14; p < 0.001), with the relationship between LV-GLS and 
      mortality being linear. CONCLUSIONS: LV-GLS is associated with all-cause 
      mortality. LV-GLS may be useful for risk stratification in patients with MAVD.
CI  - Copyright (c) 2021 American College of Cardiology Foundation. Published by Elsevier 
      Inc. All rights reserved.
FAU - Saijo, Yoshihito
AU  - Saijo Y
AD  - Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, 
      Ohio, USA.
FAU - Isaza, Nicolas
AU  - Isaza N
AD  - Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, 
      Ohio, USA.
FAU - Conic, Julijana Z
AU  - Conic JZ
AD  - Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, 
      Ohio, USA.
FAU - Desai, Milind Y
AU  - Desai MY
AD  - Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, 
      Ohio, USA.
FAU - Johnston, Douglas
AU  - Johnston D
AD  - Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, 
      Cleveland, Ohio, USA.
FAU - Roselli, Eric E
AU  - Roselli EE
AD  - Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, 
      Cleveland, Ohio, USA.
FAU - Grimm, Richard A
AU  - Grimm RA
AD  - Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, 
      Ohio, USA.
FAU - Svensson, Lars G
AU  - Svensson LG
AD  - Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, 
      Cleveland, Ohio, USA.
FAU - Kapadia, Samir
AU  - Kapadia S
AD  - Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, 
      Ohio, USA.
FAU - Obuchowski, Nancy A
AU  - Obuchowski NA
AD  - Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, 
      Ohio, USA.
FAU - Griffin, Brian P
AU  - Griffin BP
AD  - Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, 
      Ohio, USA.
FAU - Popovic, Zoran B
AU  - Popovic ZB
AD  - Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, 
      Ohio, USA. Electronic address: popoviz@ccf.org.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20210317
PL  - United States
TA  - JACC Cardiovasc Imaging
JT  - JACC. Cardiovascular imaging
JID - 101467978
SB  - IM
CIN - JACC Cardiovasc Imaging. 2021 Jul;14(7):1335-1337. PMID: 33865765
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aortic Valve Disease
MH  - *Aortic Valve Stenosis/diagnostic imaging/surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Predictive Value of Tests
MH  - Stroke Volume
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - global longitudinal strain
OT  - mixed aortic valve disease
OT  - prognostic value
OT  - speckle tracking
COIS- Funding Support and Author Disclosures The authors have reported that they have 
      no relationships relevant to the contents of this paper to disclose.
EDAT- 2021/03/22 06:00
MHDA- 2021/10/09 06:00
CRDT- 2021/03/21 20:51
PHST- 2020/08/31 00:00 [received]
PHST- 2021/01/15 00:00 [revised]
PHST- 2021/01/20 00:00 [accepted]
PHST- 2021/03/22 06:00 [pubmed]
PHST- 2021/10/09 06:00 [medline]
PHST- 2021/03/21 20:51 [entrez]
AID - S1936-878X(21)00088-7 [pii]
AID - 10.1016/j.jcmg.2021.01.020 [doi]
PST - ppublish
SO  - JACC Cardiovasc Imaging. 2021 Jul;14(7):1324-1334. doi: 
      10.1016/j.jcmg.2021.01.020. Epub 2021 Mar 17.