PMID- 33744411
OWN - NLM
STAT- MEDLINE
DCOM- 20220207
LR  - 20220207
IS  - 2210-741X (Electronic)
IS  - 2210-7401 (Linking)
VI  - 45
IP  - 3
DP  - 2021 May
TI  - Adult autoimmune enteropathy in autoimmune hepatitis patient. Case report and 
      literature review.
PG  - 101673
LID - S2210-7401(21)00052-8 [pii]
LID - 10.1016/j.clinre.2021.101673 [doi]
AB  - Autoimmune enteropathy (AIE) is a rare disease characterized by prolonged 
      diarrhea, vomiting and weight loss; although it is mainly a rare pediatric 
      disease, over the years a number of adults have also been found to be affected. 
      In this study, we present a case report of a 73-year-old woman with a history of 
      autoimmune hepatitis, antinuclear (ANA) and positive anti-enterocyte antibodies 
      (AEA), who has suffered two months of intractable diarrhea, nausea, anorexia and 
      severe weight loss. The histological examination of the endoscopic duodenal 
      mucosa biopsies revealed severe shortening and flattening of the villi, resulting 
      in mucosal atrophy. The immunohistochemical study revealed a polymorphic lymphoid 
      population, exhibiting a B cell (CD20+) phenotype in follicles and a T cell 
      phenotype (CD3+) in the diffuse component within the lamina propria. Our patient 
      had a complete recovery after two weeks of taking prednisone and following a 
      gluten-rich diet. To our knowledge this is the first case of autoimmune 
      enteropathy in adults with ANA and AEA 7 years after a diagnosis of autoimmune 
      hepatitis. To date, the patient is still in clinical remission on a low dose of 
      orally administered predinisone without any additional immunosuppression.
CI  - Copyright (c) 2021 Elsevier Masson SAS. All rights reserved.
FAU - Iaquinto, Gaetano
AU  - Iaquinto G
AD  - Division of Gastroenterology, Department of Internal Medicine, S. Rita Hospital, 
      Atripalda, Avellino, Italy. Electronic address: iaquintog@yahoo.it.
FAU - Panico, Luigi
AU  - Panico L
AD  - Department of Pathology, AORN dei Colli, Monaldi Hospital, Naples, Italy.
FAU - Luongo, Gelsomina
AU  - Luongo G
AD  - Department of Pathology, San G. Moscati Hospital, Avellino, Italy.
FAU - Tenneriello, Valentina
AU  - Tenneriello V
AD  - Department of Pathology, San G. Moscati Hospital, Avellino, Italy.
FAU - Iaquinto, Salvatore
AU  - Iaquinto S
AD  - Division of Gastroenterology, San Filippo Neri Hospital, Rome, Italy.
FAU - Giardullo, Nicola
AU  - Giardullo N
AD  - Division of Gastroenterology, San G. Moscati Hospital, Avellino, Italy.
FAU - Rotondi Aufiero, Vera
AU  - Rotondi Aufiero V
AD  - Institute of Food Sciences, CNR, Avellino, Italy.
FAU - Mazzarella, Giuseppe
AU  - Mazzarella G
AD  - Institute of Food Sciences, CNR, Avellino, Italy.
FAU - Rispoli, Raffaella
AU  - Rispoli R
AD  - Department of Mental and Physical Health and Preventive Medicine, Section of 
      Human Anatomy, University of Campania "Luigi Vanvitelli", Naples, Italy.
FAU - Lucariello, Angela
AU  - Lucariello A
AD  - Department of Sport Sciences and Wellness, University of Naples "Parthenope", 
      Naples, Italy.
FAU - Perna, Angelica
AU  - Perna A
AD  - Department of Medicine and Health Sciences "Vincenzo Tiberio", University of 
      Molise, Campobasso, Italy.
FAU - De Luca, Antonio
AU  - De Luca A
AD  - Department of Mental and Physical Health and Preventive Medicine, Section of 
      Human Anatomy, University of Campania "Luigi Vanvitelli", Naples, Italy.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20210317
PL  - France
TA  - Clin Res Hepatol Gastroenterol
JT  - Clinics and research in hepatology and gastroenterology
JID - 101553659
RN  - Autoimmune enteropathy
SB  - IM
MH  - Aged
MH  - Diarrhea
MH  - Female
MH  - *Hepatitis, Autoimmune/complications/diagnosis/drug therapy
MH  - Humans
MH  - *Polyendocrinopathies, Autoimmune/complications/diagnosis
MH  - Weight Loss
OTO - NOTNLM
OT  - Autoimmune enteropathy
OT  - Autoimmune hepatitis
OT  - Diarrhea
EDAT- 2021/03/22 06:00
MHDA- 2022/02/08 06:00
CRDT- 2021/03/21 20:57
PHST- 2020/05/28 00:00 [received]
PHST- 2021/01/25 00:00 [revised]
PHST- 2021/03/02 00:00 [accepted]
PHST- 2021/03/22 06:00 [pubmed]
PHST- 2022/02/08 06:00 [medline]
PHST- 2021/03/21 20:57 [entrez]
AID - S2210-7401(21)00052-8 [pii]
AID - 10.1016/j.clinre.2021.101673 [doi]
PST - ppublish
SO  - Clin Res Hepatol Gastroenterol. 2021 May;45(3):101673. doi: 
      10.1016/j.clinre.2021.101673. Epub 2021 Mar 17.