PMID- 33744512
OWN - NLM
STAT- MEDLINE
DCOM- 20210520
LR  - 20220503
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Print)
IS  - 0022-3956 (Linking)
VI  - 137
DP  - 2021 May
TI  - Sleep abnormalities in individuals at clinical high risk for psychosis.
PG  - 328-334
LID - S0022-3956(21)00150-3 [pii]
LID - 10.1016/j.jpsychires.2021.03.006 [doi]
AB  - Youth at clinical high risk (CHR) represent a unique population enriched for 
      precursors of major psychiatric disorders. Sleep disturbances are consistently 
      reported in CHR individuals. However, there is a dearth of studies investigating 
      quantifiable objective measures of sleep dysfunction in CHR youth. In this study, 
      sleep high density (hd)-EEG recordings were collected in twenty-two CHR and 
      twenty healthy control (HC) subjects. Sleep architecture parameters, as well as 
      sleep EEG power spectra in five frequency bands, were computed and compared 
      between CHR and HC groups during non-rapid eye movement (NREM) sleep. 
      Furthermore, correlation analyses between sleep EEG power spectra, sleep 
      architecture parameters, and clinical symptoms, assessed with the scale of 
      prodromal symptoms (SOPS), were conducted in CHR participants. Our results show 
      that CHR individuals had more wakefulness after sleep onset (WASO) compared to HC 
      participants. CHR also showed a higher NREM sleep gamma EEG power, which was 
      observed in a large fronto-parieto-occipital area, relative to HC. Additionally, 
      higher NREM gamma activity in lateral fronto-occipital regions was associated 
      with more WASO, and increased NREM gamma power in medial fronto/parietal areas 
      correlated with worse SOPS negative symptoms. Altogether, these findings suggest 
      that topographically specific increases in EEG gamma activity during NREM sleep 
      represent neurophysiological signatures underlying some of the objectively 
      assessed sleep disturbances and clinical symptoms of CHR individuals.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Mayeli, Ahmad
AU  - Mayeli A
AD  - Department of Psychiatry, University of Pittsburgh, USA.
FAU - LaGoy, Alice
AU  - LaGoy A
AD  - Department of Psychiatry, University of Pittsburgh, USA.
FAU - Donati, Francesco L
AU  - Donati FL
AD  - Department of Psychiatry, University of Pittsburgh, USA.
FAU - Kaskie, Rachel E
AU  - Kaskie RE
AD  - Department of Psychiatry, University of Pittsburgh, USA.
FAU - Najibi, Seyed Morteza
AU  - Najibi SM
AD  - Center for Molecular Protein Science, Lund University, Lund, Sweden.
FAU - Ferrarelli, Fabio
AU  - Ferrarelli F
AD  - Department of Psychiatry, University of Pittsburgh, USA. Electronic address: 
      ferrarellif@upmc.edu.
LA  - eng
GR  - R01 MH113827/MH/NIMH NIH HHS/United States
GR  - R21 MH119543/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20210308
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
SB  - IM
MH  - Adolescent
MH  - Electroencephalography
MH  - Humans
MH  - Polysomnography
MH  - *Psychotic Disorders/complications
MH  - Sleep
MH  - Sleep Stages
MH  - Sleep, REM
PMC - PMC8085028
MID - NIHMS1681239
OTO - NOTNLM
OT  - Clinical high risk
OT  - NREM EEG gamma power
OT  - Sleep architecture
OT  - Sleep disturbance
COIS- Conflict of Interest The authors declare that there is no conflict of interest.
EDAT- 2021/03/22 06:00
MHDA- 2021/05/21 06:00
PMCR- 2022/05/01
CRDT- 2021/03/21 21:00
PHST- 2020/10/26 00:00 [received]
PHST- 2021/02/27 00:00 [revised]
PHST- 2021/03/02 00:00 [accepted]
PHST- 2021/03/22 06:00 [pubmed]
PHST- 2021/05/21 06:00 [medline]
PHST- 2021/03/21 21:00 [entrez]
PHST- 2022/05/01 00:00 [pmc-release]
AID - S0022-3956(21)00150-3 [pii]
AID - 10.1016/j.jpsychires.2021.03.006 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2021 May;137:328-334. doi: 10.1016/j.jpsychires.2021.03.006. 
      Epub 2021 Mar 8.