PMID- 33744745
OWN - NLM
STAT- MEDLINE
DCOM- 20210616
LR  - 20210616
IS  - 1879-1360 (Electronic)
IS  - 0022-3999 (Linking)
VI  - 144
DP  - 2021 May
TI  - Bodily pain in survivors of acute respiratory distress syndrome: A 1-year 
      longitudinal follow-up study.
PG  - 110418
LID - S0022-3999(21)00063-5 [pii]
LID - 10.1016/j.jpsychores.2021.110418 [doi]
AB  - PURPOSE: Acute respiratory distress syndrome (ARDS) survivors frequently 
      experience bodily pain during recovery after the intensive care unit. 
      Longitudinal course, risk factors and associations with physical and 
      neuropsychological health is lacking. METHODS: We collected self-reported pain 
      using the Short Form-36 Bodily Pain (SF-36 BP) scale, normalized for sex and age 
      (range: 0-100; higher score = less pain), along with physical and mental health 
      measures in a multi-center, prospective cohort of 826 ARDS survivors at 6- and 
      12-month follow-up. We examined baseline and ICU variables' associations with 
      pain via separate unadjusted regression models. RESULTS: Pain prevalence (SF-36 
      BP </=40) was 45% and 42% at 6 and 12 months, respectively. Among 706 patients with 
      both 6- and 12-month data, 34% reported pain at both timepoints. Pre-ARDS 
      employment was associated with less pain at 6-months (mean difference (standard 
      error), 5.7 (0.9), p < 0.001) and 12-months (6.3 (0.9), p < 0.001); smoking 
      history was associated with greater pain (-5.0 (0.9), p < 0.001, and - 5.4 (1.0), 
      p < 0.001, respectively). In-ICU opioid use was associated with greater pain 
      (-6.3 (2.7), p = 0.02, and - 7.3 (2.8), p = 0.01, respectively). At 6 months, 174 
      (22%) patients reported co-occurring pain, depression and anxiety, and 227 (33%) 
      reported co-occurring pain and impaired physical function. CONCLUSION: Nearly 
      half of ARDS survivors reported bodily pain at 6- and 12-month follow-up; 
      one-third reported pain at both time points. Pre-ARDS unemployment, smoking 
      history, and in-ICU opioid use may identify patients who report greater pain 
      during recovery. Given its frequent co-occurrence, clinicians should manage both 
      physical and neuropsychological issues when pain is reported.
CI  - Copyright (c) 2021. Published by Elsevier Inc.
FAU - Probert, Julia M
AU  - Probert JM
AD  - Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA. 
      Electronic address: jprobert@partners.org.
FAU - Lin, Shihong
AU  - Lin S
AD  - Department of Counseling, Higher Education and Special Education University of 
      Maryland, College Park, MD, USA. Electronic address: slin68@umd.edu.
FAU - Yan, Haijuan
AU  - Yan H
AD  - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of 
      Medicine, Baltimore, MD, USA. Electronic address: hyan8@jhu.edu.
FAU - Leoutsakos, Jeannie-Marie S
AU  - Leoutsakos JS
AD  - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of 
      Medicine, Baltimore, MD, USA. Electronic address: jeannie-marie@jhu.edu.
FAU - Dinglas, Victor D
AU  - Dinglas VD
AD  - Division of Pulmonary and Critical Care Medicine, Outcomes After Critical Illness 
      and Surgery (OACIS) Group, Johns Hopkins University School of Medicine, 
      Baltimore, MD, USA. Electronic address: Victor.dinglas@jhmi.edu.
FAU - Hosey, Megan M
AU  - Hosey MM
AD  - Department of Physical Medicine and Rehabilitation and Division of Pulmonary and 
      Critical Care Medicine, Outcomes After Critical Illness and Surgery (OACIS) 
      Group, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: 
      mhosey@jhu.edu.
FAU - Parker, Ann M
AU  - Parker AM
AD  - Division of Pulmonary and Critical Care Medicine, Outcomes After Critical Illness 
      and Surgery (OACIS) Group, Johns Hopkins University School of Medicine, 
      Baltimore, MD, USA. Electronic address: ann.parker@jhmi.edu.
FAU - Hopkins, Ramona O
AU  - Hopkins RO
AD  - Neuroscience Center and Psychology Department, Brigham Young University, Provo, 
      Utah, USA and Pulmonary and Critical Care Medicine, Intermountain Health Care, 
      and Center for Humanizing Critical Care, Intermountain Medical Center, Murray, 
      UT, USA. Electronic address: mona_hopkins@byu.edu.
FAU - Needham, Dale M
AU  - Needham DM
AD  - Division of Pulmonary and Critical Care Medicine, Outcomes After Critical Illness 
      and Surgery (OACIS) Group, Johns Hopkins University School of Medicine, 
      Baltimore, MD, USA; Department of Physical Medicine and Rehabilitation and 
      Division of Pulmonary and Critical Care Medicine, Outcomes After Critical Illness 
      and Surgery (OACIS) Group, Johns Hopkins School of Medicine, Baltimore, MD, USA. 
      Electronic address: Dale.Needham@jhmi.edu.
FAU - Neufeld, Karin J
AU  - Neufeld KJ
AD  - Department of Psychiatry and Behavioral Sciences, Outcomes After Critical Illness 
      and Surgery (OACIS) Group, Johns Hopkins School of Medicine, Baltimore, MD, USA. 
      Electronic address: kneufel2@jhmi.edu.
LA  - eng
GR  - R24 HL111895/HL/NHLBI NIH HHS/United States
GR  - R01 HL091760/HL/NHLBI NIH HHS/United States
GR  - R01 HL091760/HL/NHLBI NIH HHS/United States
GR  - UL1 TR000424/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20210317
PL  - England
TA  - J Psychosom Res
JT  - Journal of psychosomatic research
JID - 0376333
SB  - IM
MH  - Adult
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain/*epidemiology
MH  - Respiratory Distress Syndrome/*therapy
MH  - Self Report
MH  - Survivors/*statistics & numerical data
OTO - NOTNLM
OT  - ARDS
OT  - Anxiety
OT  - Critical illness survival
OT  - Depression
OT  - Pain
OT  - Physical function
EDAT- 2021/03/22 06:00
MHDA- 2021/06/17 06:00
CRDT- 2021/03/21 21:08
PHST- 2020/07/02 00:00 [received]
PHST- 2021/02/04 00:00 [revised]
PHST- 2021/03/10 00:00 [accepted]
PHST- 2021/03/22 06:00 [pubmed]
PHST- 2021/06/17 06:00 [medline]
PHST- 2021/03/21 21:08 [entrez]
AID - S0022-3999(21)00063-5 [pii]
AID - 10.1016/j.jpsychores.2021.110418 [doi]
PST - ppublish
SO  - J Psychosom Res. 2021 May;144:110418. doi: 10.1016/j.jpsychores.2021.110418. Epub 
      2021 Mar 17.