PMID- 33744994
OWN - NLM
STAT- MEDLINE
DCOM- 20220208
LR  - 20220208
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 36
IP  - 10
DP  - 2021 Oct
TI  - Association between high-density lipoprotein cholesterol levels and major adverse 
      cardiovascular events in patients who underwent coronary computed tomography 
      angiography: FU-CCTA registry.
PG  - 1457-1465
LID - 10.1007/s00380-021-01831-0 [doi]
AB  - It is unclear whether higher levels of serum high-density lipoprotein cholesterol 
      (HDL-C) prevent major adverse cardiovascular events (MACE). We prospectively 
      evaluated 501 patients who had undergone coronary computed tomography angiography 
      at Fukuoka University Hospital and either were clinically suspected of having 
      coronary artery disease (CAD) or had at least one cardiovascular risk factor with 
      a follow-up of up to 5 years. The primary endpoint was MACE (cardiovascular 
      death, ischemic stroke, acute myocardial infarction and coronary 
      revascularization). The patients were divided into tertiles according to the 
      HDL-C level: 47 mg/dl >/= HDL-C level [n = 167, lower HDL-C level (L-HDL)], 
      58 mg/dl >/= HDL-C level >/= 48 mg/dl [n = 167, middle HDL-C level (M-HDL)] and HDL-C 
      level >/= 59 mg/dl [n = 167, higher HDL-C level (H-HDL)] groups. There were 
      significant differences in %CAD among the L-HDL, M-HDL and H-HDL groups. 
      Unexpectedly, there was no difference in %MACE between M-HDL and H-HDL, although 
      %MACE in M-HDL was significantly lower than that in L-HDL (p < 0.05). By a 
      multivariate logistic regression analysis, MACE in H-HDL-C was independently 
      associated with diabetes mellitus (DM) (p = 0.03). A Kaplan-Meier curve according 
      to the HDL subgroup indicated that M-HDL, not H-HDL, enjoyed the greatest freedom 
      from MACE among the 3 groups (log-rank test p = 0.047). Finally, the results of a 
      Cox regression model indicated that L-HDL and H-HDL had significantly higher risk 
      of MACE than M-HDL. In conclusions, patients with middle HDL-C levels, not higher 
      HDL-C levels, showed the greatest freedom from MACE. Patients with higher HDL-C 
      levels need to be strictly managed for DM to prevent MACE.
CI  - (c) 2021. Springer Japan KK, part of Springer Nature.
FAU - Kawahira, Yuto
AU  - Kawahira Y
AD  - Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, 
      Jonan-ku, Fukuoka, 814-0180, Japan.
AD  - Department of Cardiology, Fukuoka University Nishijin Hospital, Fukuoka, Japan.
FAU - Shiga, Yuhei
AU  - Shiga Y
AD  - Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, 
      Jonan-ku, Fukuoka, 814-0180, Japan.
FAU - Inoue, Hiroko
AU  - Inoue H
AD  - Department of Cardiology, Fukuoka University Nishijin Hospital, Fukuoka, Japan.
FAU - Suematsu, Yasunori
AU  - Suematsu Y
AD  - Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, 
      Jonan-ku, Fukuoka, 814-0180, Japan.
FAU - Tashiro, Kohei
AU  - Tashiro K
AD  - Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, 
      Jonan-ku, Fukuoka, 814-0180, Japan.
FAU - Kato, Yuta
AU  - Kato Y
AD  - Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, 
      Jonan-ku, Fukuoka, 814-0180, Japan.
FAU - Fujimi, Kanta
AU  - Fujimi K
AD  - Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, 
      Jonan-ku, Fukuoka, 814-0180, Japan.
AD  - Cardiac Rehabilitation Center, Fukuoka University Hospital, Fukuoka, Japan.
FAU - Takamiya, Yosuke
AU  - Takamiya Y
AD  - Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, 
      Jonan-ku, Fukuoka, 814-0180, Japan.
FAU - Kuwano, Takashi
AU  - Kuwano T
AD  - Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, 
      Jonan-ku, Fukuoka, 814-0180, Japan.
FAU - Sugihara, Makoto
AU  - Sugihara M
AD  - Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, 
      Jonan-ku, Fukuoka, 814-0180, Japan.
FAU - Miura, Shin-Ichiro
AU  - Miura SI
AD  - Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, 
      Jonan-ku, Fukuoka, 814-0180, Japan. miuras@cis.fukuoka-u.ac.jp.
AD  - Department of Cardiology, Fukuoka University Nishijin Hospital, Fukuoka, Japan. 
      miuras@cis.fukuoka-u.ac.jp.
AD  - Cardiac Rehabilitation Center, Fukuoka University Hospital, Fukuoka, Japan. 
      miuras@cis.fukuoka-u.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20210321
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
RN  - 0 (Cholesterol, HDL)
SB  - IM
MH  - Cholesterol, HDL
MH  - *Computed Tomography Angiography
MH  - Coronary Angiography
MH  - *Coronary Artery Disease/diagnostic imaging/epidemiology
MH  - Humans
MH  - Registries
MH  - Risk Factors
OTO - NOTNLM
OT  - Coronary artery disease
OT  - Coronary computed tomography angiography
OT  - High-density lipoprotein cholesterol
OT  - Major adverse cardiovascular events
EDAT- 2021/03/22 06:00
MHDA- 2022/02/09 06:00
CRDT- 2021/03/21 21:21
PHST- 2020/12/25 00:00 [received]
PHST- 2021/03/05 00:00 [accepted]
PHST- 2021/03/22 06:00 [pubmed]
PHST- 2022/02/09 06:00 [medline]
PHST- 2021/03/21 21:21 [entrez]
AID - 10.1007/s00380-021-01831-0 [pii]
AID - 10.1007/s00380-021-01831-0 [doi]
PST - ppublish
SO  - Heart Vessels. 2021 Oct;36(10):1457-1465. doi: 10.1007/s00380-021-01831-0. Epub 
      2021 Mar 21.