PMID- 33747190
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231104
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 21
IP  - 5
DP  - 2021 May
TI  - Clinical diagnostic value of combined detection of IMA, D-D and MCP-1 in acute 
      myocardial infarction.
PG  - 457
LID - 10.3892/etm.2021.9888 [doi]
LID - 457
AB  - The aim of the study was to analyze the clinical value of the combined detection 
      of ischemia-modified albumin (IMA), D-dimer (D-D) and monocyte chemoattractant 
      protein-1 (MCP-1) in the diagnosis of acute myocardial infarction (AMI). 
      Altogether 87 patients with AMI from January 2017 to January 2018 were enrolled 
      in the AMI group, and 82 patients without coronary artery disease were included 
      in the control group. The serum levels of IMA, D-D, MCP-1, cardiac troponin 
      (CTnT) and high-sensitivity C-reactive protein (hs-CRP) in the two groups were 
      detected by ELISA. The blood lipids of the two groups and the levels of IMA, D-D, 
      MCP-1 after treatment were detected. The association between IMA, D-D, MCP-1, 
      CTnT, hs-CRP and blood lipid in patients with AMI was analyzed. The values of 
      IMA, D-D, and MCP-1 alone and combined in the diagnosis of AMI were analyzed by 
      ROC curve. The levels of IMA, D-D, MCP-1, CTnT and hs-CRP in the AMI group were 
      significantly higher than those in the control group (P<0.05). The levels of IMA, 
      D-D and MCP-1 in the patients with poor prognosis were significantly higher than 
      those of the good prognosis group (P<0.05). The changes of IMA, D-D and MCP-1 
      levels were positively correlated with the levels of CTT and hs-CRP (P<0.05). The 
      AUC, specificity and sensitivity of patients with AMI diagnosed with MCP-1 alone 
      were 0.8084, 81.61 and 69.51%, respectively. Those of patients diagnosed by D-D 
      were 0.7302, 59.77 and 81.71%, those of patients diagnosed by IMA alone were 
      0.7289, 58.62 and 80.49%, and those of patients detected by the combination of 
      MCP-1, D-D and IMA were 0.9047, 58.62 and 93.90%. In conclusion, the levels of 
      IMA, D-D and MCP-1 in AMI patients are higher than those in the control group. 
      The levels of IMA, D-D and MCP-1 were positively correlated with CTnT and hs-CRP 
      levels in AMI patients. Combined detection of IMA, D-D, and MCP-1 can improve the 
      accuracy.
CI  - Copyright: (c) Ding et al.
FAU - Ding, Mei
AU  - Ding M
AD  - Department of Cardiology, China-Japan Union Hospital of Jilin University, 
      Changchun, Jilin 130033, P.R. China.
FAU - Li, Min
AU  - Li M
AD  - Department of Clinical Laboratory, China-Japan Union Hospital of Jilin 
      University, Changchun, Jilin 130033, P.R. China.
FAU - Yang, Hailing
AU  - Yang H
AD  - Department of Emergency, China-Japan Union Hospital of Jilin University, 
      Changchun, Jilin 130033, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20210302
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC7967864
OTO - NOTNLM
OT  - AMI
OT  - D-D
OT  - IMA
OT  - MCP-1
OT  - clinical prognosis
OT  - combined detection
COIS- The authors declare that they have no competing interests.
EDAT- 2021/03/23 06:00
MHDA- 2021/03/23 06:01
PMCR- 2021/03/02
CRDT- 2021/03/22 08:11
PHST- 2019/09/18 00:00 [received]
PHST- 2020/11/25 00:00 [accepted]
PHST- 2021/03/22 08:11 [entrez]
PHST- 2021/03/23 06:00 [pubmed]
PHST- 2021/03/23 06:01 [medline]
PHST- 2021/03/02 00:00 [pmc-release]
AID - ETM-0-0-09888 [pii]
AID - 10.3892/etm.2021.9888 [doi]
PST - ppublish
SO  - Exp Ther Med. 2021 May;21(5):457. doi: 10.3892/etm.2021.9888. Epub 2021 Mar 2.