PMID- 33747483
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240331
IS  - 2048-7177 (Print)
IS  - 2048-7177 (Electronic)
IS  - 2048-7177 (Linking)
VI  - 9
IP  - 3
DP  - 2021 Mar
TI  - Effects of solvent-solvent fractionation on the total terpenoid content and in 
      vitro anti-inflammatory activity of Serevenia buxifolia bark extract.
PG  - 1720-1735
LID - 10.1002/fsn3.2149 [doi]
AB  - Severinia buxifolia (Rutaceae) is often used as a traditional medical plant. The 
      present study was carried out to estimate the effects of solvents (petroleum 
      ether and hexane: ethyl acetate) used in liquid-liquid extraction to total 
      terpenoid content (TTC) and in vitro anti-inflammatory activity of the extracts 
      obtained from S. buxifolia bark. The results showed that solvent fractionation 
      increased the TTC compared with crude extracts. The hexane: ethyl acetate bark 
      extract fraction (HEF) had the highest TTC (731.48 microg/ml) in comparison with the 
      petroleum ether bark extract fraction (PEF) (564.81 microg/ml) and the crude extract 
      (CE) (184.26 microg/ml). In addition, one of composition of terpenoid of S. 
      buxifolia, namely ursolic acid, was determined by HPLC method from the crude CE 
      and the fractions PEF and HEF: 2.44 mug/g DW, 3.56 mug/g DW and 5.04 mug/g DW, 
      respectively. The samples had an in vitro anti-inflammatory activity comparable 
      with that of two reference standards (aspirin and indomethacin). Particularly, 
      the HEF fraction had the highest in vitro anti-inflammatory activity (i.e., 
      albumin denaturation: IC(50) = 147.91 mug/mL, heat-induced hemolysis: 
      IC(50) = 159.91 mug/mL, proteinase inhibition: IC(50) = 117.72 mug/mL, and 
      lipoxygenase activity: IC(50) = 90.45 mug/mL). Besides, the preliminary 
      experiments of this study were conducted to determine the influences of 
      maceration factors (solvent type, temperature, and time) for S. buxifolia bark 
      extract. The TTC ranged from 453.70 to 842.59 mg linalool/g DW, and the 
      extraction yield from 2.40% to 5.120% in all extracts. Based on TTC and EY, the 
      hexane: acetone mixture is recommended as the optimal solvent to obtain the crude 
      bark extract (CE) at 46 degrees C for 24 hr of maceration. Extracts of S. buxifolia bark 
      are a promising source for the treatment of inflammatory diseases.
CI  - (c) 2021 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.
FAU - Truong, Dieu-Hien
AU  - Truong DH
AUID- ORCID: 0000-0002-9166-4261
AD  - Faculty of Applied Sciences Ton Duc Thang University Ho Chi Minh City Vietnam.
FAU - Ta, Nhat Thuy Anh
AU  - Ta NTA
AD  - Faculty of Applied Sciences Ton Duc Thang University Ho Chi Minh City Vietnam.
FAU - Pham, Thanh Vy
AU  - Pham TV
AD  - Faculty of Applied Sciences Ton Duc Thang University Ho Chi Minh City Vietnam.
FAU - Huynh, Tan Dat
AU  - Huynh TD
AD  - Faculty of Applied Sciences Ton Duc Thang University Ho Chi Minh City Vietnam.
FAU - Do, Quoc Truong Giang
AU  - Do QTG
AD  - Faculty of Applied Sciences Ton Duc Thang University Ho Chi Minh City Vietnam.
FAU - Dinh, Nguyen Chau Giang
AU  - Dinh NCG
AD  - Faculty of Applied Sciences Ton Duc Thang University Ho Chi Minh City Vietnam.
FAU - Dang, Cong Danh
AU  - Dang CD
AD  - Faculty of Applied Sciences Ton Duc Thang University Ho Chi Minh City Vietnam.
FAU - Nguyen, Thi Kim Chi
AU  - Nguyen TKC
AD  - Faculty of Applied Sciences Ton Duc Thang University Ho Chi Minh City Vietnam.
FAU - Bui, Anh Vo
AU  - Bui AV
AD  - Faculty of Applied Sciences Ton Duc Thang University Ho Chi Minh City Vietnam.
LA  - eng
PT  - Journal Article
DEP - 20210127
PL  - United States
TA  - Food Sci Nutr
JT  - Food science & nutrition
JID - 101605473
PMC - PMC7958534
OTO - NOTNLM
OT  - Serevenia buxifolia extract
OT  - in vitro anti-inflammatory
OT  - solvent-solvent fractionation
OT  - total terpenoid content
COIS- The authors declare no financial or commercial conflict of interest. The authors 
      confirm that this manuscript is an honest, accurate, and transparent account of 
      the study being reported.
EDAT- 2021/03/23 06:00
MHDA- 2021/03/23 06:01
PMCR- 2021/01/27
CRDT- 2021/03/22 08:14
PHST- 2020/10/13 00:00 [received]
PHST- 2021/01/06 00:00 [revised]
PHST- 2021/01/13 00:00 [accepted]
PHST- 2021/03/22 08:14 [entrez]
PHST- 2021/03/23 06:00 [pubmed]
PHST- 2021/03/23 06:01 [medline]
PHST- 2021/01/27 00:00 [pmc-release]
AID - FSN32149 [pii]
AID - 10.1002/fsn3.2149 [doi]
PST - epublish
SO  - Food Sci Nutr. 2021 Jan 27;9(3):1720-1735. doi: 10.1002/fsn3.2149. eCollection 
      2021 Mar.