PMID- 33749789
OWN - NLM
STAT- MEDLINE
DCOM- 20221202
LR  - 20221202
IS  - 2042-7158 (Electronic)
IS  - 0022-3573 (Linking)
VI  - 74
IP  - 12
DP  - 2022 Nov 25
TI  - Systemic administration of sunflower oil exerts neuroprotection in a mouse model 
      of transient focal cerebral ischaemia.
PG  - 1776-1783
LID - 10.1093/jpp/rgab007 [doi]
AB  - OBJECTIVES: Natural products are valuable sources of nutraceuticals for the 
      prevention or treatment of ischemic stroke, a major cause of death and severe 
      disability worldwide. Among the mechanisms implicated in cerebral 
      ischemia-reperfusion damage, oxidative stress exerts a pivotal role in disease 
      progression. Given the high antioxidant potential of most components of sunflower 
      oil, we have explored its effects on ischemic brain injury produced in the mouse 
      by transient occlusion of the middle cerebral artery (MCAo). KEY FINDINGS: 
      Intraperitoneal (i.p.) administration of sunflower oil at doses of 3 ml/kg (48 h, 
      24 h and 1 h before MCAo) significantly reduced brain infarct volume and oedema 
      assessed 24 h after the insult. This neuroprotective treatment schedule also 
      prevented the elevation of brain lipid peroxidation produced by MCAo-reperfusion 
      injury. By contrast, doses of 0.03 ml/kg of sunflower oil resulted ineffective on 
      both cerebral damage and lipid peroxidation. Although sunflower oil did not 
      affect serum levels of Diacron-reactive oxygen metabolites (d-ROMs), both 0.03 
      and 3 ml/kg dosing regimens resulted in the preservation of serum biological 
      antioxidant potential (BAP) that was otherwise dramatically reduced 24 h after 
      MCAo. CONCLUSIONS: Sunflower oil represents a promising source of neuroprotective 
      extracts/compounds that can be exploited for the prevention and/or treatment of 
      cerebral ischemia.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the Royal 
      Pharmaceutical Society. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - La Russa, Daniele
AU  - La Russa D
AD  - Section of Preclinical and Translational Pharmacology, Department of Pharmacy, 
      Health and Nutritional Sciences, University of Calabria, Rende, Cosenza, Italy.
FAU - Montesano, Domenico
AU  - Montesano D
AD  - Department of Pharmaceutical Sciences, Section of Food Science and Nutrition, 
      University of Perugia, Perugia, Italy.
FAU - Pellegrino, Daniela
AU  - Pellegrino D
AD  - Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, 
      Cosenza, Italy.
FAU - Frisina, Marialaura
AU  - Frisina M
AD  - Section of Preclinical and Translational Pharmacology, Department of Pharmacy, 
      Health and Nutritional Sciences, University of Calabria, Rende, Cosenza, Italy.
FAU - Bagetta, Giacinto
AU  - Bagetta G
AD  - Section of Preclinical and Translational Pharmacology, Department of Pharmacy, 
      Health and Nutritional Sciences, University of Calabria, Rende, Cosenza, Italy.
FAU - Fallarino, Francesca
AU  - Fallarino F
AD  - Department of Experimental Medicine, University of Perugia, Perugia, Italy.
FAU - Amantea, Diana
AU  - Amantea D
AUID- ORCID: 0000-0002-7513-3495
AD  - Section of Preclinical and Translational Pharmacology, Department of Pharmacy, 
      Health and Nutritional Sciences, University of Calabria, Rende, Cosenza, Italy.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Pharm Pharmacol
JT  - The Journal of pharmacy and pharmacology
JID - 0376363
RN  - 0 (Sunflower Oil)
RN  - 0 (Antioxidants)
RN  - 0 (Neuroprotective Agents)
SB  - IM
MH  - Animals
MH  - Mice
MH  - Neuroprotection
MH  - Sunflower Oil/metabolism/pharmacology/therapeutic use
MH  - Antioxidants/metabolism
MH  - *Neuroprotective Agents
MH  - *Ischemic Attack, Transient/drug therapy/prevention & control/metabolism
MH  - *Brain Ischemia/drug therapy/prevention & control/metabolism
MH  - Disease Models, Animal
MH  - Brain
MH  - Infarction, Middle Cerebral Artery/drug therapy/metabolism
OTO - NOTNLM
OT  - brain ischemia
OT  - lipid peroxidation
OT  - neuroprotection
OT  - oxidative stress
OT  - sunflower oil
OT  - vitamin E
EDAT- 2021/03/23 06:00
MHDA- 2022/12/03 06:00
CRDT- 2021/03/22 12:49
PHST- 2020/11/02 00:00 [received]
PHST- 2021/01/13 00:00 [accepted]
PHST- 2021/03/23 06:00 [pubmed]
PHST- 2022/12/03 06:00 [medline]
PHST- 2021/03/22 12:49 [entrez]
AID - 6179829 [pii]
AID - 10.1093/jpp/rgab007 [doi]
PST - ppublish
SO  - J Pharm Pharmacol. 2022 Nov 25;74(12):1776-1783. doi: 10.1093/jpp/rgab007.