PMID- 33750415
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210325
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 13
IP  - 1
DP  - 2021 Mar 9
TI  - Diagnostic significance of serum PP4R1 and its predictive value for the 
      development of chronic complications in patients with type 2 diabetes mellitus.
PG  - 27
LID - 10.1186/s13098-021-00642-7 [doi]
LID - 27
AB  - BACKGROUND: Protein phosphatase 4 regulatory subunit 1 (PP4R1) is one of the 
      regulatory subunits of PP4. It has been determined to be involved in the 
      regulation of TNF-alpha-induced hepatic insulin resistance and gluconeogenesis. 
      Considering the important role of PP4R1 in hepatic insulin resistance, the 
      current study explored the expression and diagnostic value of PP4R1 in type 2 
      diabetes mellitus (T2DM) patients and further investigated its predictive value 
      for the development of chronic complications. METHOD: Hundred and five patients 
      with T2DM and 97 healthy controls were collected. qRT-PCR was used for the 
      measurement of serum PP4R1 mRNA level in both T2DM and control groups. The 
      diagnostic value of PP4R1 in T2DM patients was evaluated using receiver operating 
      characteristic (ROC) curve. Kaplan-Meier methods and Cox regression analysis were 
      used to evaluate the predictive value of PP4R1 for the development of chronic 
      complications in T2DM patients. RESULTS: PP4R1 was determined to be elevated in 
      the serum of T2DM patients compared with healthy controls. Serum PP4R1 had the 
      potential to distinguish T2DM patients from healthy controls with a sensitivity 
      of 81.9% and specificity of 82.5%. Patients with high PP4R1 expression 
      experienced more chronic complications events. The multivariate Cox analysis 
      results suggested that serum PP4R1 expression was an independent factor for the 
      occurrence of chronic complications for T2DM patients.  CONCLUSION: PP4R1 is 
      elevated in the serum of T2DM patients, had the potential to distinguish T2DM 
      patients from healthy controls. PP4R1 serves as a promising biomarker for 
      predicting the risk of future chronic complications in T2DM patients.
FAU - Li, Wenjing
AU  - Li W
AD  - Endocrinology Department, The Second People's Hospital of Liaocheng, Liaocheng, 
      Shandong, 252600, China.
FAU - Peng, Lanbo
AU  - Peng L
AD  - Endocrinology Department, Liaocheng People's Hospital, Liaocheng, Shandong, 
      252000, China.
FAU - Yang, Chao
AU  - Yang C
AD  - Endocrinology Department, The Second People's Hospital of Liaocheng, Liaocheng, 
      Shandong, 252600, China.
FAU - Chen, Guangmin
AU  - Chen G
AD  - Nephrology and Urology Centre, University-Town Hospital of Chongqing Medical 
      University, No. 55, University-Town Middle Road, Chongqing, 401551, China. 
      gm8rfegk@163.com.
LA  - eng
PT  - Journal Article
DEP - 20210309
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC7945353
OTO - NOTNLM
OT  - Chronic complications
OT  - Diagnosis
OT  - PP4R1
OT  - T2DM
COIS- The authors declare that they have no competing interests.
EDAT- 2021/03/23 06:00
MHDA- 2021/03/23 06:01
PMCR- 2021/03/09
CRDT- 2021/03/22 18:08
PHST- 2020/09/29 00:00 [received]
PHST- 2021/02/22 00:00 [accepted]
PHST- 2021/03/22 18:08 [entrez]
PHST- 2021/03/23 06:00 [pubmed]
PHST- 2021/03/23 06:01 [medline]
PHST- 2021/03/09 00:00 [pmc-release]
AID - 10.1186/s13098-021-00642-7 [pii]
AID - 642 [pii]
AID - 10.1186/s13098-021-00642-7 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2021 Mar 9;13(1):27. doi: 10.1186/s13098-021-00642-7.