PMID- 33752448
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20211025
IS  - 1545-4126 (Electronic)
IS  - 0147-006X (Linking)
VI  - 44
DP  - 2021 Jul 8
TI  - The Role of the Medial Prefrontal Cortex in Moderating Neural Representations of 
      Self and Other in Primates.
PG  - 295-313
LID - 10.1146/annurev-neuro-101420-011820 [doi]
AB  - As a frontal node in the primate social brain, the medial prefrontal cortex 
      (MPFC) plays a critical role in coordinating one's own behavior with respect to 
      that of others. Current literature demonstrates that single neurons in the MPFC 
      encode behavior-related variables such as intentions, actions, and rewards, 
      specifically for self and other, and that the MPFC comes into play when 
      reflecting upon oneself and others. The social moderator account of MPFC function 
      can explain maladaptive social cognition in people with autism spectrum disorder, 
      which tips the balance in favor of self-centered perspectives rather than taking 
      into consideration the perspective of others. Several strands of evidence suggest 
      a hypothesis that the MPFC represents different other mental models, depending on 
      the context at hand, to better predict others' emotions and behaviors. This 
      hypothesis also accounts for aberrant MPFC activity in autistic individuals while 
      they are mentalizing others.
FAU - Isoda, Masaki
AU  - Isoda M
AD  - Division of Behavioral Development, Department of System Neuroscience, National 
      Institute for Physiological Sciences, National Institutes of Natural Sciences, 
      Okazaki, Aichi 444-8585, Japan; email: isodam@nips.ac.jp.
AD  - Department of Physiological Sciences, School of Life Science, The Graduate 
      University for Advanced Studies (SOKENDAI), Hayama, Kanagawa 240-0193, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210322
PL  - United States
TA  - Annu Rev Neurosci
JT  - Annual review of neuroscience
JID - 7804039
SB  - IM
MH  - Animals
MH  - *Autism Spectrum Disorder
MH  - Brain Mapping
MH  - *Magnetic Resonance Imaging
MH  - Prefrontal Cortex
MH  - Primates
OTO - NOTNLM
OT  - autism spectrum disorder
OT  - medial prefrontal cortex
OT  - mental model
OT  - other-mentalizing
OT  - social cognition
EDAT- 2021/03/24 06:00
MHDA- 2021/10/26 06:00
CRDT- 2021/03/23 05:37
PHST- 2021/03/24 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/03/23 05:37 [entrez]
AID - 10.1146/annurev-neuro-101420-011820 [doi]
PST - ppublish
SO  - Annu Rev Neurosci. 2021 Jul 8;44:295-313. doi: 
      10.1146/annurev-neuro-101420-011820. Epub 2021 Mar 22.