PMID- 33753004
OWN - NLM
STAT- MEDLINE
DCOM- 20211125
LR  - 20220531
IS  - 2212-1692 (Electronic)
IS  - 1875-9572 (Linking)
VI  - 62
IP  - 3
DP  - 2021 May
TI  - Correlations between serum BDNF levels and neurodevelopmental outcomes in infants 
      of mothers with gestational diabetes.
PG  - 298-304
LID - S1875-9572(21)00024-3 [pii]
LID - 10.1016/j.pedneo.2020.12.012 [doi]
AB  - BACKGROUND: Diabetes during pregnancy is associated with an increased risk of 
      foetal and neonatal complications and long-term complications in the offspring. 
      Brain-derived neurotrophic factor (BDNF), a neurotrophin that has a crucial role 
      in neurogenesis modulation and neural pathway maturation during neurodevelopment, 
      may have a role in protecting neurons against injury and diseases by modulating 
      glucose metabolism. The aim of this study was to investigate the possible 
      relationship between the serum BDNF levels of infants of mothers with gestational 
      diabetes (IMGD) and neurodevelopmental outcomes of the children after birth. 
      METHODS: A total of 24 candidates, including 8 IMGD and 16 healthy infants, were 
      recruited for the study. Medical records were reviewed. Serum BDNF levels of the 
      study participants were collected at birth and at 6 and 12 months of age. 
      Developmental outcomes of each candidate were assessed using the Bayley Scales of 
      Infant Development III (BSID III) at 6 and 12 months of corrected age. RESULTS: 
      Compared to non-IMGD, IMGD had greater mean body weight (p = 0.04) and height 
      (p < 0.01) at age 12 months. The language composite score was significantly lower 
      in IMGD at 12 months of age (p = 0.038). The BDNF content was significantly 
      higher in the non-IMGD than in the IMGD group at 12 months of age (p = 0.013). 
      CONCLUSION: In this study, we demonstrated that infants of mothers with 
      gestational diabetes do worse in language development and have lower BDNF levels 
      at 12 months of age. There may be a close correlation between language outcomes 
      and serum BDNF levels at 12 months of age. A follow-up study on future 
      developmental status is warranted.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Su, Chung-Hao
AU  - Su CH
AD  - Department of Pediatrics, Chia-Yi Chang-Gung Memorial Hospital & Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan, 83301.
FAU - Liu, Ta-Yu
AU  - Liu TY
AD  - Section of Neonatology, Kaohsiung Chang-Gung Memorial Hospital & Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan, 83301.
FAU - Chen, I-Ting
AU  - Chen IT
AD  - Section of Neonatology, Kaohsiung Chang-Gung Memorial Hospital & Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan, 83301.
FAU - Ou-Yang, Mei-Chen
AU  - Ou-Yang MC
AD  - Section of Neonatology, Kaohsiung Chang-Gung Memorial Hospital & Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan, 83301.
FAU - Huang, Li-Tong
AU  - Huang LT
AD  - Section of Pediatric Neurology, Kaohsiung Chang-Gung Memorial Hospital & Chang 
      Gung University College of Medicine, Kaohsiung, Taiwan, 83301.
FAU - Tsai, Ching-Chang
AU  - Tsai CC
AD  - Section of Obstetric -Gynecology, Kaohsiung Chang-Gung Memorial Hospital & Chang 
      Gung University College of Medicine, Kaohsiung, Taiwan, 83301.
FAU - Chen, Chih-Cheng
AU  - Chen CC
AD  - Section of Neonatology, Kaohsiung Chang-Gung Memorial Hospital & Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan, 83301; Department of Early 
      Childhood Care and Education, Cheng-Shiu University, Kaohsiung, Taiwan, 83301. 
      Electronic address: charllysc@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210223
PL  - Singapore
TA  - Pediatr Neonatol
JT  - Pediatrics and neonatology
JID - 101484755
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - *Brain-Derived Neurotrophic Factor/blood
MH  - Child Development
MH  - *Diabetes, Gestational
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Mothers
MH  - *Neurodevelopmental Disorders
MH  - Pregnancy
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Gestational diabetic mellitus
OT  - Language composite score
OT  - Neurodevelopment
COIS- Declaration of competing interest The authors have declared that they have no 
      conflicts of interest relevant to this article.
EDAT- 2021/03/24 06:00
MHDA- 2021/11/26 06:00
CRDT- 2021/03/23 06:11
PHST- 2020/06/14 00:00 [received]
PHST- 2020/11/09 00:00 [revised]
PHST- 2020/12/13 00:00 [accepted]
PHST- 2021/03/24 06:00 [pubmed]
PHST- 2021/11/26 06:00 [medline]
PHST- 2021/03/23 06:11 [entrez]
AID - S1875-9572(21)00024-3 [pii]
AID - 10.1016/j.pedneo.2020.12.012 [doi]
PST - ppublish
SO  - Pediatr Neonatol. 2021 May;62(3):298-304. doi: 10.1016/j.pedneo.2020.12.012. Epub 
      2021 Feb 23.