PMID- 33755196
OWN - NLM
STAT- MEDLINE
DCOM- 20211220
LR  - 20211220
IS  - 1365-2362 (Electronic)
IS  - 0014-2972 (Linking)
VI  - 51
IP  - 7
DP  - 2021 Jul
TI  - Pattern of macrovascular invasion in hepatocellular carcinoma.
PG  - e13542
LID - 10.1111/eci.13542 [doi]
AB  - BACKGROUND AND AIMS: In patients with hepatocellular carcinoma (HCC), 
      macrovascular invasion (MaVI) limits treatment options and decreases survival. 
      Detailed data on the relationship between MaVI extension and patients' 
      characteristics, and its impact on patients' outcome are limited. We evaluated 
      the prevalence and extension of MaVI in a large cohort of consecutive HCC 
      patients, analysing its association with liver disease and tumour 
      characteristics, as well as with treatments performed and patients' survival. 
      METHODS: We analysed data of 4774 patients diagnosed with HCC recorded in the 
      Italian Liver Cancer (ITA.LI.CA) database (2008-2018). Recursive partition 
      analysis (RPA) was performed to evaluate interactions between MaVI, clinical 
      variables and treatment, exploring the inter-relationship determining overall 
      survival. RESULTS: MaVI prevalence was 11.1%, and median survival of these 
      patients was 6.0 months (95% CI, 5.1-7.1). MaVI was associated with younger age 
      at diagnosis, presence of symptoms, worse Performance Status (PS) and liver 
      function, high alphafetoprotein levels and large HCCs. MaVI extension was 
      associated with worse PS, ascites and greater impairment in liver function. RPA 
      identified patients' categories with different treatment indications and 
      survival, ranging from 2.4 months in those with PS > 1 and ascites, regardless of 
      MaVI extension (receiving best supportive care in 90.3% of cases), to 14.1 months 
      in patients with PS 0-1, no ascites and Vp1-Vp2 MaVI (treated with surgery in 
      19.1% of cases). CONCLUSIONS: MaVI presence and extension, together with PS and 
      ascites, significantly affect patients' survival and treatment selection. The 
      decision tree based on these parameters may help assess patients' prognosis and 
      inform therapeutic decisions.
CI  - (c) 2021 Stichting European Society for Clinical Investigation Journal Foundation. 
      Published by John Wiley & Sons Ltd.
FAU - Guarino, Maria
AU  - Guarino M
AUID- ORCID: 0000-0002-0460-4122
AD  - Department of Clinical Medicine and Surgery, Gastroenterology Unit, University of 
      Napoli "Federico II", Napoli, Italy.
FAU - Cucchetti, Alessandro
AU  - Cucchetti A
AD  - Department of Medical and Surgical Sciences, General Surgery of the 
      Morgagni-Pierantoni Hospital Forli, Alma Mater Studiorum - University of Bologna, 
      Bologna, Italy.
AD  - Department of Internal Medicine, Ospedale per gli Infermi di Faenza, Faenza, 
      Italy.
FAU - Pontillo, Giuseppina
AU  - Pontillo G
AD  - Department of Clinical Medicine and Surgery, Gastroenterology Unit, University of 
      Napoli "Federico II", Napoli, Italy.
FAU - Farinati, Fabio
AU  - Farinati F
AD  - Department of Surgery, Oncology and Gastroenterology, University of Padova, 
      Padova, Italy.
FAU - Benevento, Francesca
AU  - Benevento F
AD  - Division of Internal Medicine, Azienda Ospedaliero-Universitaria di Bologna, 
      Bologna, Italy.
FAU - Rapaccini, Gian Ludovico
AU  - Rapaccini GL
AD  - Gastroenterology Unit, IRCCS, Fondazione Policlinico Universitario A. Gemelli, 
      Roma, Italy.
FAU - Di Marco, Maria
AU  - Di Marco M
AD  - Medicine Unit, Bolognini Hospital, Seriate, Italy.
FAU - Caturelli, Eugenio
AU  - Caturelli E
AD  - Gastroenterology Unit, Belcolle Hospital, Viterbo, Italy.
FAU - Zoli, Marco
AU  - Zoli M
AD  - Department of Medical and Surgical Sciences, Internal Medicine Unit, University 
      of Bologna, Bologna, Italy.
FAU - Rodolfo, Sacco
AU  - Rodolfo S
AD  - Gastroenterology and Digestive Endoscopy Unit, Foggia University Hospital, 
      Foggia, Italy.
FAU - Cabibbo, Giuseppe
AU  - Cabibbo G
AD  - Department of Health Promotion, Mother & Child Care, Internal Medicine & Medical 
      Specialties, PROMISE, Gastroenterology & Hepatology Unit, University of Palermo, 
      Palermo, Italy.
FAU - Marra, Fabio
AU  - Marra F
AD  - Department of Experimental and Clinical Medicine, Internal Medicine and 
      Hepatology Unit, University of Firenze, Firenze, Italy.
FAU - Mega, Andrea
AU  - Mega A
AD  - Gastroenterology Unit, Bolzano Regional Hospital, Bolzano, Italy.
FAU - Gasbarrini, Antonio
AU  - Gasbarrini A
AD  - Internal Medicine and Gastroenterology Unit, Policlinico Gemelli, Universita 
      Cattolica del Sacro Cuore, Roma, Italy.
FAU - Svegliati-Baroni, Gianluca
AU  - Svegliati-Baroni G
AD  - Gastroenterology Unit, Polytechnic University of Marche, Ancona, Italy.
FAU - Foschi, Francesco Giuseppe
AU  - Foschi FG
AD  - Department of Internal Medicine, Ospedale per gli Infermi di Faenza, Faenza, 
      Italy.
FAU - Missale, Gabriele
AU  - Missale G
AD  - Infectious Diseases and Hepatology Unit, Azienda Ospedaliero-Universitaria di 
      Parma, Parma, Italy.
FAU - Masotto, Alberto
AU  - Masotto A
AD  - Gastroenterology Unit, Ospedale Sacro Cuore Don Calabria, Negrar, Italy.
FAU - Nardone, Gerardo
AU  - Nardone G
AD  - Department of Clinical Medicine and Surgery, Hepato-Gastroenterology Unit, 
      University of Napoli "Federico II", Napoli, Italy.
FAU - Raimondo, Giovanni
AU  - Raimondo G
AD  - Department of Clinical and Experimental Medicine, Clinical and Molecular 
      Hepatology Unit, University of Messina, Messina, Italy.
FAU - Azzaroli, Francesco
AU  - Azzaroli F
AD  - Department of Surgical and Medical Sciences, Gastroenterology Unit, Alma Mater 
      Studiorum-Universita of Bologna, Bologna, Italy.
FAU - Vidili, Gianpaolo
AU  - Vidili G
AD  - Department of Medical, Surgical and Experimental Sciences, Clinica Medica Unit, 
      University of Sassari, Azienda Ospedaliero-Universitaria di Sassari, Sassari, 
      Italy.
FAU - Oliveri, Filippo
AU  - Oliveri F
AD  - Department of Clinical and Experimental Medicine, Hepatology and Liver 
      Physiopathology Laboratory and Internal Medicine, University of Pisa, Pisa, 
      Italy.
FAU - Trevisani, Franco
AU  - Trevisani F
AD  - Department of Medical and Surgical Sciences, Semeiotics Unit, Alma Mater 
      Studiorum-University of Bologna, Bologna, Italy.
FAU - Giannini, Edoardo G
AU  - Giannini EG
AD  - Department of Internal Medicine, Gastroenterology Unit, IRCCS Ospedale 
      Policlinico San Martino, University of Genova, Genova, Italy.
FAU - Morisco, Filomena
AU  - Morisco F
AD  - Department of Clinical Medicine and Surgery, Gastroenterology Unit, University of 
      Napoli "Federico II", Napoli, Italy.
CN  - ITA.LI.CA Group
LA  - eng
PT  - Journal Article
DEP - 20210323
PL  - England
TA  - Eur J Clin Invest
JT  - European journal of clinical investigation
JID - 0245331
RN  - 0 (Antineoplastic Agents)
RN  - 9ZOQ3TZI87 (Sorafenib)
SB  - IM
MH  - Ablation Techniques
MH  - Aged
MH  - Antineoplastic Agents/therapeutic use
MH  - Ascites
MH  - Carcinoma, Hepatocellular/etiology/*pathology/therapy
MH  - End Stage Liver Disease
MH  - Female
MH  - Hepatectomy
MH  - Hepatitis B, Chronic/complications
MH  - Hepatitis C, Chronic/complications
MH  - Humans
MH  - Italy
MH  - Liver Diseases, Alcoholic/complications
MH  - Liver Neoplasms/etiology/*pathology/therapy
MH  - Liver Transplantation
MH  - Male
MH  - Mesenteric Veins/*pathology
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Non-alcoholic Fatty Liver Disease/complications
MH  - Patient Acuity
MH  - Portal Vein/*pathology
MH  - Prognosis
MH  - Registries
MH  - Sorafenib/therapeutic use
MH  - Survival Rate
MH  - Tumor Burden
OTO - NOTNLM
OT  - cirrhosis
OT  - hepatocellular carcinoma
OT  - loco-regional treatment
OT  - portal vein thrombosis
OT  - surgery
OT  - transplantation
FIR - Biselli, Maurizio
IR  - Biselli M
FIR - Caraceni, Paolo
IR  - Caraceni P
FIR - Garuti, Francesca
IR  - Garuti F
FIR - Gramenzi, Annagiulia
IR  - Gramenzi A
FIR - Neri, Andrea
IR  - Neri A
FIR - Rampoldi, Davide
IR  - Rampoldi D
FIR - Santi, Valentina
IR  - Santi V
FIR - Forgione, Antonella
IR  - Forgione A
FIR - Granito, Alessandro
IR  - Granito A
FIR - Muratori, Luca
IR  - Muratori L
FIR - Piscaglia, Fabio
IR  - Piscaglia F
FIR - Sansone, Vito
IR  - Sansone V
FIR - Tovoli, Francesco
IR  - Tovoli F
FIR - Dajti, Elton
IR  - Dajti E
FIR - Marasco, Giovanni
IR  - Marasco G
FIR - Ravaioli, Federico
IR  - Ravaioli F
FIR - Cappelli, Alberta
IR  - Cappelli A
FIR - Golfieri, Rita
IR  - Golfieri R
FIR - Mosconi, Cristina
IR  - Mosconi C
FIR - Renzulli, Matteo
IR  - Renzulli M
FIR - Cela, Ester Marina
IR  - Cela EM
FIR - Facciorusso, Antonio
IR  - Facciorusso A
FIR - Pelizzaro, Filippo
IR  - Pelizzaro F
FIR - Imondi, Angela
IR  - Imondi A
FIR - Sartori, Anna
IR  - Sartori A
FIR - Penzo, Barbara
IR  - Penzo B
FIR - Cacciato, Valentina
IR  - Cacciato V
FIR - Casagrande, Edoardo
IR  - Casagrande E
FIR - Moscatelli, Alessandro
IR  - Moscatelli A
FIR - Pellegatta, Gaia
IR  - Pellegatta G
FIR - Pieri, Giulia
IR  - Pieri G
FIR - de Matthaeis, Nicoletta
IR  - de Matthaeis N
FIR - Allegrini, Gloria
IR  - Allegrini G
FIR - Lauria, Valentina
IR  - Lauria V
FIR - Ghittoni, Giorgia
IR  - Ghittoni G
FIR - Pelecca, Giorgio
IR  - Pelecca G
FIR - Chegai, Fabrizio
IR  - Chegai F
FIR - Coratella, Fabio
IR  - Coratella F
FIR - Ortenzi, Mariano
IR  - Ortenzi M
FIR - Olivari, Andrea
IR  - Olivari A
FIR - Inno, Alessandro
IR  - Inno A
FIR - Marchetti, Fabiana
IR  - Marchetti F
FIR - Busacca, Anita
IR  - Busacca A
FIR - Camma, Calogero
IR  - Camma C
FIR - Di Martino, Vincenzo
IR  - Di Martino V
FIR - Rizzo, Giacomo Emanuele Maria
IR  - Rizzo GEM
FIR - Franze, Maria Stella
IR  - Franze MS
FIR - Saitta, Carlo
IR  - Saitta C
FIR - Sauchella, Assunta
IR  - Sauchella A
FIR - Bevilacqua, Vittoria
IR  - Bevilacqua V
FIR - Borghi, Alberto
IR  - Borghi A
FIR - Gardini, Andrea Casadei
IR  - Gardini AC
FIR - Conti, Fabio
IR  - Conti F
FIR - Berardinelli, Dante
IR  - Berardinelli D
FIR - Ercolani, Giorgio
IR  - Ercolani G
FIR - Napoli, Lucia
IR  - Napoli L
FIR - Campani, Claudia
IR  - Campani C
FIR - Di Bonaventura, Chiara
IR  - Di Bonaventura C
FIR - Gitto, Stefano
IR  - Gitto S
FIR - Coccoli, Pietro
IR  - Coccoli P
FIR - Malerba, Antonio
IR  - Malerba A
FIR - Capasso, Mario
IR  - Capasso M
FIR - Fiorentino, Andrea
IR  - Fiorentino A
FIR - Pignata, Luca
IR  - Pignata L
FIR - Cossiga, Valentina
IR  - Cossiga V
FIR - Romagnoli, Veronica
IR  - Romagnoli V
EDAT- 2021/03/24 06:00
MHDA- 2021/12/21 06:00
CRDT- 2021/03/23 12:34
PHST- 2021/02/27 00:00 [revised]
PHST- 2020/12/23 00:00 [received]
PHST- 2021/03/10 00:00 [accepted]
PHST- 2021/03/24 06:00 [pubmed]
PHST- 2021/12/21 06:00 [medline]
PHST- 2021/03/23 12:34 [entrez]
AID - 10.1111/eci.13542 [doi]
PST - ppublish
SO  - Eur J Clin Invest. 2021 Jul;51(7):e13542. doi: 10.1111/eci.13542. Epub 2021 Mar 
      23.