PMID- 33755212
OWN - NLM
STAT- MEDLINE
DCOM- 20211006
LR  - 20211022
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Print)
IS  - 0023-852X (Linking)
VI  - 131
IP  - 10
DP  - 2021 Oct
TI  - pT3 N0 Laryngeal Squamous Cell Carcinoma: Oncologic Outcomes and Prognostic 
      Factors of Surgically Treated Patients.
PG  - 2262-2268
LID - 10.1002/lary.29528 [doi]
AB  - OBJECTIVES/HYPOTHESIS: To assess the disease control, survival rates, and 
      prognostic factors of exclusive surgical treatment for patients with pT3 N0 
      laryngeal squamous cell carcinoma (LSCC). STUDY DESIGN: Multicentric 
      retrospective cohort study. METHODS: Multicentric retrospective case series of 
      previously untreated patients with pT3 R0N0 LSCC, who received exclusive surgery 
      between 2011 and 2019. Tumor location; subsite involvement; grading; and 
      lymphatic, vascular, and perineural invasion were reported. Overall survival 
      (OS), disease-specific survival (DSS), and disease-free survival (DFS) were 
      measured. RESULTS: Fifty-four patients (mean age 67.1; male sex 83.3%; mean 
      follow-up period 37 months) underwent total laryngectomy (48.1%) or partial 
      laryngectomy (51.9%). Ipsilateral or bilateral neck dissection was performed in 
      46 (85.2%) cases. Perineural invasion was more frequent in case of supraglottic 
      involvement than glottic involvement (85.7% vs. 14.3%, P = .03). Five (9.3%) 
      patients experienced recurrence (3 local recurrences, 1 nodal recurrence, 1 
      distant recurrence). Rate of recurrence differed between glottic (0%), 
      supraglottic (80%), and transglottic (20%) tumors (P = .01), with a lower risk 
      yielded by glottic involvement (odds ratio [OR], 0.05, 95% confidence interval 
      [95% CI], 0.01-0.56, P = .01). A higher risk was recorded in case of perineural 
      invasion (OR, 66.0, 95% CI, 1.41-3085.3, P = .03). The OS, DSS, and DFS were 
      79.6%, 96.3%, and 90.7%, without differences regarding the type of surgery. The 
      DFS was lower in case of supraglottic involvement when compared to purely glottic 
      LSCC (83.9% vs. 100%, P = 0.02). CONCLUSIONS: Exclusive surgery is a safe option 
      for patients with pT3 R0N0 LSCC. Adjuvant treatments or closer follow-up 
      monitoring might be considered in case of supraglottic involvement or perineural 
      invasion. LEVEL OF EVIDENCE: 4 Laryngoscope, 131:2262-2268, 2021.
CI  - (c) 2021 The Authors. The Laryngoscope published by Wiley Periodicals LLC on behalf 
      of The American Laryngological, Rhinological and Otological Society, Inc.
FAU - Mattioli, Francesco
AU  - Mattioli F
AD  - Otorhinolaryngology Head and Neck Surgery Department, University Hospital of 
      Modena, Modena, Italy.
FAU - Fermi, Matteo
AU  - Fermi M
AUID- ORCID: 0000-0002-2727-0321
AD  - Otorhinolaryngology Head and Neck Surgery Department, University Hospital of 
      Modena, Modena, Italy.
FAU - Molinari, Giulia
AU  - Molinari G
AUID- ORCID: 0000-0002-3402-4364
AD  - Otorhinolaryngology Head and Neck Surgery Department, University Hospital of 
      Modena, Modena, Italy.
FAU - Capriotti, Vincenzo
AU  - Capriotti V
AUID- ORCID: 0000-0001-5294-0449
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, University of 
      Trieste, Cattinara Hospital, Trieste, Italy.
FAU - Melegari, Gabriele
AU  - Melegari G
AD  - Anesthesiology and Reanimation Department, University Hospital of Modena, Modena, 
      Italy.
FAU - Bertolini, Federica
AU  - Bertolini F
AD  - Department of Oncology and Hematology, University Hospital of Modena, Modena, 
      Italy.
FAU - D'Angelo, Elisa
AU  - D'Angelo E
AD  - Radiation Oncology Unit, University Hospital of Modena, Modena, Italy.
FAU - Tirelli, Giancarlo
AU  - Tirelli G
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, University of 
      Trieste, Cattinara Hospital, Trieste, Italy.
FAU - Presutti, Livio
AU  - Presutti L
AD  - Otorhinolaryngology Head and Neck Surgery Department, University Hospital of 
      Modena, Modena, Italy.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20210323
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Disease-Free Survival
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Laryngeal Neoplasms/diagnosis/mortality/pathology/*surgery
MH  - Laryngectomy/*statistics & numerical data
MH  - Larynx/pathology/surgery
MH  - Lymphatic Metastasis/pathology/therapy
MH  - Male
MH  - Middle Aged
MH  - Neck Dissection/statistics & numerical data
MH  - Neoplasm Recurrence, Local/*epidemiology/prevention & control
MH  - Prognosis
MH  - Retrospective Studies
MH  - Squamous Cell Carcinoma of Head and Neck/diagnosis/mortality/pathology/*surgery
MH  - Survival Rate
PMC - PMC8518991
OTO - NOTNLM
OT  - Larynx
OT  - head and neck cancer
OT  - laryngeal cancer
OT  - laryngectomy
OT  - radiotherapy
EDAT- 2021/03/24 06:00
MHDA- 2021/10/07 06:00
PMCR- 2021/10/15
CRDT- 2021/03/23 12:35
PHST- 2021/02/17 00:00 [revised]
PHST- 2020/10/16 00:00 [received]
PHST- 2021/03/15 00:00 [accepted]
PHST- 2021/03/24 06:00 [pubmed]
PHST- 2021/10/07 06:00 [medline]
PHST- 2021/03/23 12:35 [entrez]
PHST- 2021/10/15 00:00 [pmc-release]
AID - LARY29528 [pii]
AID - 10.1002/lary.29528 [doi]
PST - ppublish
SO  - Laryngoscope. 2021 Oct;131(10):2262-2268. doi: 10.1002/lary.29528. Epub 2021 Mar 
      23.