PMID- 33755549
OWN - NLM
STAT- MEDLINE
DCOM- 20220104
LR  - 20220104
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 82
IP  - 7
DP  - 2021 Jul
TI  - A snapshot of human leukocyte antigen (HLA) diversity using data from the Allele 
      Frequency Net Database.
PG  - 496-504
LID - S0198-8859(20)30411-0 [pii]
LID - 10.1016/j.humimm.2020.10.004 [doi]
AB  - The extensive allelic variability observed in several genes related to the immune 
      response and its significance in different areas including transplantation, 
      disease association studies, diversity in human populations, among many others, 
      has led the scientific community to analyse these variants among individuals. 
      Serving as an electronic data warehouse, the Allele Frequency Net Database (AFND, 
      http://www.allelefrequencies.net) contains data on the frequency of immune 
      related genes and their corresponding alleles from more than 1700 worldwide 
      population samples covering more than ten million unrelated individuals. The 
      collection of population data sets available in AFND encompasses different 
      polymorphic regions including the highly-polymorphic human leukocyte antigen 
      (HLA) system for which more than 1200 populations are available. In this article, 
      we provide an insight of the high diversity found in the HLA region by examining 
      population data sets stored in AFND, as well as a description of the available 
      data sets for further analyses.
CI  - Copyright (c) 2020 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Gonzalez-Galarza, Faviel F
AU  - Gonzalez-Galarza FF
AD  - Center for Biomedical Research, Faculty of Medicine, Autonomous University of 
      Coahuila, Torreon, Mexico. Electronic address: faviel.gonzalez@uadec.edu.mx.
FAU - McCabe, Antony
AU  - McCabe A
AD  - Computational Biology Facility, University of Liverpool, Biosciences Building, 
      United Kingdom; Institute of Systems, Molecular and Integrative Biology, 
      University of Liverpool, Biosciences Building, United Kingdom.
FAU - Melo Dos Santos, Eduardo J
AU  - Melo Dos Santos EJ
AD  - Genetic of Complex Diseases Laboratory, Institute of Biological Sciences, Federal 
      University of Para, Brazil.
FAU - Jones, Andrew R
AU  - Jones AR
AD  - Institute of Systems, Molecular and Integrative Biology, University of Liverpool, 
      Biosciences Building, United Kingdom.
FAU - Middleton, Derek
AU  - Middleton D
AD  - Institute of Infection and Global Health, University of Liverpool, Liverpool, 
      United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201021
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Alleles
MH  - *Databases, Genetic
MH  - *Gene Frequency
MH  - *Genetic Variation
MH  - HLA Antigens/*genetics/immunology
MH  - Humans
MH  - Immunogenetics/methods
MH  - Transplantation Immunology
MH  - Web Browser
OTO - NOTNLM
OT  - Alleles
OT  - Genetic diversity
OT  - HLA
OT  - Immunogenetics databases
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/03/24 06:00
MHDA- 2022/01/05 06:00
CRDT- 2021/03/23 17:23
PHST- 2020/06/22 00:00 [received]
PHST- 2020/09/20 00:00 [revised]
PHST- 2020/10/10 00:00 [accepted]
PHST- 2021/03/24 06:00 [pubmed]
PHST- 2022/01/05 06:00 [medline]
PHST- 2021/03/23 17:23 [entrez]
AID - S0198-8859(20)30411-0 [pii]
AID - 10.1016/j.humimm.2020.10.004 [doi]
PST - ppublish
SO  - Hum Immunol. 2021 Jul;82(7):496-504. doi: 10.1016/j.humimm.2020.10.004. Epub 2020 
      Oct 21.