PMID- 33756452
OWN - NLM
STAT- MEDLINE
DCOM- 20210628
LR  - 20210628
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 1171
DP  - 2021 May 1
TI  - Determination of 13 antidepressants in blood by UPLC-MS/MS with supported liquid 
      extraction pretreatment.
PG  - 122608
LID - S1570-0232(21)00088-X [pii]
LID - 10.1016/j.jchromb.2021.122608 [doi]
AB  - Antidepressants are widely used nowadays. Due to the potential detrimental 
      consequences and involvement in forensic cases, therapeutic drug monitoring of 
      antidepressants is desired. Herein we report a method for sensitive determination 
      of 13 commonly used antidepressants in blood. An ultra-high performance liquid 
      chromatography-tandem mass spectrometry (UPLC-MS/MS) method with supported liquid 
      extraction (SLE) was developed for analysis of imipramine, desipramine, 
      fluoxetine, norfluoxetine, paroxetine, maprotiline, sertraline, citalopram, 
      clomipramine, trazodone, doxepin, clozapine and amitriptyline in this study. The 
      limits of detection (LODs) are in the range of 0.0003-0.003 ng/mL, which are 
      lower than other reported methods by several orders of magnitude. The linear 
      ranges are 0.01-200 ng/mL for norfluoxetine, paroxetine and doxepin, while the 
      linear ranges are 0.001-200 ng/mL for the rest antidepressants. The correlation 
      coefficients are over 0.99. Extraction recoveries (ER) ranging in 82.4-101.5% 
      were obtained for the target analytes. The intra-day relative standard deviations 
      (RSDs) range in 4.5-10.3% and inter-day RSDs range in 5.1-12.7%. Reasonable 
      values of matrix effect (ME) ranging in 82.5-110.4% were obtained for quality 
      control samples. The present methodology was used for the analysis of 
      antidepressants in real cases and is expected to have a wide usage for analysis 
      of antidepressants in biomedical area and forensic practice.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Ma, Weiping
AU  - Ma W
AD  - School of Stomatology and Medicine, Foshan University, Foshan 528000, Guangdong, 
      China.
FAU - Gao, Xue
AU  - Gao X
AD  - College of Environment and Resources, Chongqing Technology and Business 
      University, Chongqing 400067, China.
FAU - Guo, Hao
AU  - Guo H
AD  - Chongqing Institute of Forensic Sciences, Chongqing 400021, China. Electronic 
      address: hao.guo1982@hotmail.com.
FAU - Chen, Weiming
AU  - Chen W
AD  - School of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000, 
      Jiangxi, China. Electronic address: wader_chen@163.com.
LA  - eng
PT  - Journal Article
DEP - 20210301
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Antidepressive Agents/*blood/chemistry/isolation & purification
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Humans
MH  - Limit of Detection
MH  - Linear Models
MH  - Liquid-Liquid Extraction
MH  - Reproducibility of Results
MH  - Tandem Mass Spectrometry/*methods
OTO - NOTNLM
OT  - Antidepressants
OT  - Supported liquid extraction
OT  - Tandem mass spectrometry
OT  - Ultra-high performance liquid chromatography
EDAT- 2021/03/24 06:00
MHDA- 2021/06/29 06:00
CRDT- 2021/03/23 20:26
PHST- 2020/10/07 00:00 [received]
PHST- 2021/02/14 00:00 [revised]
PHST- 2021/02/18 00:00 [accepted]
PHST- 2021/03/24 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2021/03/23 20:26 [entrez]
AID - S1570-0232(21)00088-X [pii]
AID - 10.1016/j.jchromb.2021.122608 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2021 May 1;1171:122608. doi: 
      10.1016/j.jchromb.2021.122608. Epub 2021 Mar 1.