PMID- 33757299
OWN - NLM
STAT- MEDLINE
DCOM- 20220202
LR  - 20220202
IS  - 1931-8405 (Electronic)
IS  - 0889-2229 (Linking)
VI  - 37
IP  - 12
DP  - 2021 Dec
TI  - Impact of Human Leukocyte Antigen-Associated Polymorphisms on Variability of 
      HIV-1 Accessory and Regulatory Proteins.
PG  - 962-966
LID - 10.1089/AID.2021.0055 [doi]
AB  - HIV-1 escapes by acquiring mutations that differentially influence the course of 
      infection. Unlike HIV-1 structural and enzymatic proteins, it remains elusive 
      what extent the host immune-mediated selection pressure influences the 
      variability of the accessory (Vif, Vpu, Vpr, and Nef) and regulatory (Tat and 
      Rev) proteins. To address this, we analyzed the viral sequences encoding 
      accessory and regulatory proteins from 446 human leukocyte antigen (HLA)-typed, 
      chronically HIV-1 subtype B-infected, and treatment-naive individuals in Japan. 
      We observed that Vpu and Vpr were the most and least polymorphic proteins with 
      the average Shannon entropy scores of 0.63 and 0.38, respectively. 
      Phylogenetically corrected methods identified a total of 161 HLA-associated 
      polymorphisms; whereby Nef and Vpu had the highest (26.6%) and lowest (1.2%) 
      proportion of amino acid sites associated with HLA-class I alleles, respectively. 
      These results add further insight on the role of HLA-mediated selection pressure 
      on HIV-1 sequence polymorphisms of HIV-1 accessory and regulatory proteins.
FAU - Kamori, Doreen
AU  - Kamori D
AD  - Division of Infection and Immunity, Joint Research Center for Human Retrovirus 
      Infection, Kumamoto University, Kumamoto, Japan.
AD  - Department of Microbiology and Immunology, Muhimbili University of Health and 
      Allied Sciences, Dar es Salaam, Tanzania.
FAU - Hasan, Zafrul
AU  - Hasan Z
AD  - Division of Infection and Immunity, Joint Research Center for Human Retrovirus 
      Infection, Kumamoto University, Kumamoto, Japan.
FAU - Carlson, Jonathan
AU  - Carlson J
AD  - Department of Immunomics, Microsoft Research, Los Angeles, California, USA.
FAU - Kawana-Tachikawa, Ai
AU  - Kawana-Tachikawa A
AD  - AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
FAU - Gatanaga, Hiroyuki
AU  - Gatanaga H
AD  - Division of Infection and Immunity, Joint Research Center for Human Retrovirus 
      Infection, Kumamoto University, Kumamoto, Japan.
AD  - AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, 
      Japan.
FAU - Oka, Shinichi
AU  - Oka S
AD  - Division of Infection and Immunity, Joint Research Center for Human Retrovirus 
      Infection, Kumamoto University, Kumamoto, Japan.
AD  - AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, 
      Japan.
FAU - Ueno, Takamasa
AU  - Ueno T
AUID- ORCID: 0000-0003-4852-4236
AD  - Division of Infection and Immunity, Joint Research Center for Human Retrovirus 
      Infection, Kumamoto University, Kumamoto, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210430
PL  - United States
TA  - AIDS Res Hum Retroviruses
JT  - AIDS research and human retroviruses
JID - 8709376
RN  - 0 (HLA Antigens)
RN  - 0 (Human Immunodeficiency Virus Proteins)
RN  - 0 (Viral Regulatory and Accessory Proteins)
RN  - 0 (nef Gene Products, Human Immunodeficiency Virus)
SB  - IM
MH  - *HIV Infections/genetics
MH  - *HIV-1/genetics
MH  - HLA Antigens/genetics
MH  - Human Immunodeficiency Virus Proteins/genetics
MH  - Humans
MH  - Viral Regulatory and Accessory Proteins/genetics
MH  - nef Gene Products, Human Immunodeficiency Virus/genetics
OTO - NOTNLM
OT  - HLA class I
OT  - accessory/regulatory proteins
OT  - entropy score
OT  - polymorphisms
EDAT- 2021/03/25 06:00
MHDA- 2022/02/03 06:00
CRDT- 2021/03/24 05:35
PHST- 2021/03/25 06:00 [pubmed]
PHST- 2022/02/03 06:00 [medline]
PHST- 2021/03/24 05:35 [entrez]
AID - 10.1089/AID.2021.0055 [doi]
PST - ppublish
SO  - AIDS Res Hum Retroviruses. 2021 Dec;37(12):962-966. doi: 10.1089/AID.2021.0055. 
      Epub 2021 Apr 30.