PMID- 33759320
OWN - NLM
STAT- MEDLINE
DCOM- 20210709
LR  - 20220531
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Linking)
VI  - 75
IP  - 7
DP  - 2021 Jul
TI  - A personalised diet study: The interaction between ApoA2 -265T > C polymorphism 
      and dietary inflammatory index on oxidative and inflammatory markers and lipid 
      profile in patients with type 2 diabetes mellitus: A cross-sectional study.
PG  - e14178
LID - 10.1111/ijcp.14178 [doi]
AB  - BACKGROUND: This study aimed to investigate the interaction between dietary 
      inflammatory index (DII) and apolipoproteinA2 265T > C (ApoA2 -265T > C) 
      polymorphism on inflammatory and oxidative markers and lipid profile in type 2 
      diabetes mellitus (T2DM) patients. METHODS: In this cross-sectional study, 157 
      patients with T2DM were recruited. A food-frequency questionnaire was used for 
      DII calculation. Inflammatory, oxidative and lipid biomarkers were measured. 
      Real-time polymerase chain reaction (PCR) method was used for ApoA2 genotyping 
      determination. RESULTS: In the current study, serum 8-iso-PGF2alpha and CRP were 
      significantly higher, and serum SOD activity was significantly lower in subjects 
      with CC genotype than TT homozygous in both crude and adjusted (for DII and AAs 
      intake) models. Also, C-allele carriers compared with people with TT genotype had 
      lower PTX3 in both models. In addition, serum TG level was significantly higher 
      in TC genotype than TT homozygous in adjusted model. Moreover, subjects with CC 
      homozygous and high DII level had significantly higher 8-iso-PGF2alpha level compared 
      to those with TT genotype and low DII (reference group) in adjusted (for BMI, 
      age, sexuality and AAs intake) model. Our results also showed that in TC 
      genotypes with low DII and CC homozygous with both low and high DII, PTX3 
      concentrations were significantly lower than the reference group. In addition, CC 
      carriers with low DII had significantly higher CRP level compared to the 
      reference group. Moreover, our results reported significant higher TG in TC 
      genotype with low DII and also higher total cholesterol level in CC genotype with 
      low DII than the reference group. CONCLUSION: These findings indicate that CC 
      genotype might predict higher inflammatory and oxidative status level compared to 
      T allele carriers. An inflammatory diet may accelerate oxidative stress in 
      subjects with CC genotype. However, the association between APOA2 -265T > C 
      polymorphism and inflammation and lipid profile is presented less modifiable by 
      DII.
CI  - (c) 2021 John Wiley & Sons Ltd.
FAU - Karimi, Elmira
AU  - Karimi E
AUID- ORCID: 0000-0001-7871-2313
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetic, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Tondkar, Pourya
AU  - Tondkar P
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetic, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Sotoudeh, Gity
AU  - Sotoudeh G
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Qorbani, Mostafa
AU  - Qorbani M
AD  - Non-communicable Diseases Research Center, Alborz University of Medical Sciences, 
      Karaj, Iran.
AD  - Chronic Diseases Research Center, Endocrinology and Metabolism Population 
      Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Rafiee, Masoumeh
AU  - Rafiee M
AD  - Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
FAU - Koohdani, Fariba
AU  - Koohdani F
AD  - Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences 
      Institute, Tehran University of Medical Sciences, Tehran, Iran.
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, International Campus, Tehran University of Medical Sciences, 
      Tehran, Iran.
LA  - eng
GR  - 20414/Tehran University of Medical Sciences/
PT  - Journal Article
DEP - 20210501
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
RN  - 0 (APOA2 protein, human)
RN  - 0 (Apolipoprotein A-II)
RN  - 0 (Biomarkers)
RN  - 0 (Lipids)
SB  - IM
MH  - Apolipoprotein A-II/genetics
MH  - Biomarkers
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - Diet
MH  - Genotype
MH  - Humans
MH  - Lipids
MH  - Oxidative Stress/genetics
EDAT- 2021/03/25 06:00
MHDA- 2021/07/10 06:00
CRDT- 2021/03/24 07:10
PHST- 2021/02/15 00:00 [revised]
PHST- 2020/12/03 00:00 [received]
PHST- 2021/03/22 00:00 [accepted]
PHST- 2021/03/25 06:00 [pubmed]
PHST- 2021/07/10 06:00 [medline]
PHST- 2021/03/24 07:10 [entrez]
AID - 10.1111/ijcp.14178 [doi]
PST - ppublish
SO  - Int J Clin Pract. 2021 Jul;75(7):e14178. doi: 10.1111/ijcp.14178. Epub 2021 May 
      1.