PMID- 33761009
OWN - NLM
STAT- MEDLINE
DCOM- 20210607
LR  - 20210607
IS  - 1432-8798 (Electronic)
IS  - 0304-8608 (Linking)
VI  - 166
IP  - 6
DP  - 2021 Jun
TI  - Genetic characterization of a novel porcine reproductive and respiratory syndrome 
      virus type I strain from southwest China.
PG  - 1769-1773
LID - 10.1007/s00705-021-04998-z [doi]
AB  - Porcine reproductive and respiratory syndrome (PRRS) is one of the most 
      economically devastating viral diseases in the global pig industry. Recently, we 
      isolated and plaque-purified porcine reproductive and respiratory syndrome virus 
      (PRRSV) strain SC2020-1 from "aborted piglets" on a farm in Sichuan, China. To 
      investigate the molecular biological characteristics of this strain, it was 
      subjected to genome sequencing and analysis. The full-length genome sequence of 
      strain SC2020-1 was 87.7% identical to that of the Lelystad strain (PRRSV type I 
      protoype strain) and 82.2-84.8% identical to PRRSV type I isolates from China. 
      NSP2, ORF3, and ORF4 were the most variable regions and contained discontinuous 
      deletions or insertions when compared to other PRRSV type I strains. Phylogenetic 
      analysis of the complete genome sequence showed that SC2020-1 clustered with 
      PRRSV type I but outside of the three previously described branches (Lelystad 
      virus-like, Amervac PRRS-like, and BJEU06-1-like). The Nsp2 gene was in the same 
      branch with EUGDHD strains from China. This is the first report of PRRSV type I 
      infection associated with abortion in sows in southwest China. Close attention 
      should be paid to the prevention and control of this evolving virus.
FAU - Zhao, Jun
AU  - Zhao J
AUID- ORCID: 0000-0002-5804-6816
AD  - College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
FAU - Zhu, Ling
AU  - Zhu L
AD  - College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
AD  - Key , Laboratory of Animal Diseases and Human Health of Sichuan Province, 
      Chengdu, China.
FAU - Deng, Huidan
AU  - Deng H
AD  - College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
FAU - Li, Fengqing
AU  - Li F
AD  - College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
FAU - Xu, Lei
AU  - Xu L
AD  - College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
FAU - Sun, Xiangang
AU  - Sun X
AD  - College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
FAU - Yin, Wenqi
AU  - Yin W
AD  - Animal Breeding and Genetics Key Laboratory of Sichuan Province, Sichuan Animal 
      Science Academy, Chengdu, China.
FAU - Kuang, Shengyao
AU  - Kuang S
AD  - Animal Breeding and Genetics Key Laboratory of Sichuan Province, Sichuan Animal 
      Science Academy, Chengdu, China.
FAU - Li, Shuwei
AU  - Li S
FAU - Zhou, Yuancheng
AU  - Zhou Y
AD  - Animal Breeding and Genetics Key Laboratory of Sichuan Province, Sichuan Animal 
      Science Academy, Chengdu, China. abtczyc@163.com.
AD  - Livestock and Poultry Biological Products Key Laboratory of Sichuan Province, 
      Sichuan Animal Science Academy, Chengdu, China. abtczyc@163.com.
AD  - Livestock and Poultry Biological Products Key Laboratory of Sichuan Province, 
      Animtech Bioengineering Co. Ltd, Chengdu, China. abtczyc@163.com.
FAU - Xu, Zhiwen
AU  - Xu Z
AUID- ORCID: 0000-0002-9508-6593
AD  - College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China. 
      abtcxzw@126.com.
AD  - Key , Laboratory of Animal Diseases and Human Health of Sichuan Province, 
      Chengdu, China. abtcxzw@126.com.
LA  - eng
GR  - 2018NZ0150/The Science and Technology Program of Sichuan Province/
GR  - 2018YFD0500802/The National Key Research and Development Program/
GR  - CARS-SVDIP/The Sichuan Veterinary Medicine and Drug Innovation Group of the China 
      Agricultural Research System/
PT  - Journal Article
DEP - 20210324
PL  - Austria
TA  - Arch Virol
JT  - Archives of virology
JID - 7506870
SB  - IM
MH  - Animals
MH  - China/epidemiology
MH  - Disease Outbreaks/veterinary
MH  - Phylogeny
MH  - Porcine Reproductive and Respiratory Syndrome/epidemiology/*virology
MH  - Porcine respiratory and reproductive syndrome virus/*genetics
MH  - Swine
EDAT- 2021/03/25 06:00
MHDA- 2021/06/08 06:00
CRDT- 2021/03/24 17:33
PHST- 2020/11/30 00:00 [received]
PHST- 2020/12/26 00:00 [accepted]
PHST- 2021/03/25 06:00 [pubmed]
PHST- 2021/06/08 06:00 [medline]
PHST- 2021/03/24 17:33 [entrez]
AID - 10.1007/s00705-021-04998-z [pii]
AID - 10.1007/s00705-021-04998-z [doi]
PST - ppublish
SO  - Arch Virol. 2021 Jun;166(6):1769-1773. doi: 10.1007/s00705-021-04998-z. Epub 2021 
      Mar 24.